(30 nodes) Response to ethanol network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103459627	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (517 aa)
	LOC103475890	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (523 aa)
	LOC103462295	Zgc:153993. (263 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103467741	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1451 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	glra3	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1152 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	LOC103463443	Thromboxane A2 receptor. (378 aa)
	LOC103463442	Thromboxane A2 receptor. (379 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (446 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	LOC103457349	Solute carrier family 10 member 1. (334 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103471530	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	LOC103479803	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC103479798	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	tufm	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (446 aa)
	Unc79	Uncharacterized protein. (132 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (483 aa)
	ogg1	8-oxoguanine DNA glycosylase. (388 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (298 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	LOC103458516	Uncharacterized protein. (356 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (310 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
Cldn5	LOC103479092	ENSPREP00000017247	ENSPREP00000010324	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.749
LOC103457349	nr0b2	ENSPREP00000015362	ENSPREP00000013093	Solute carrier family 10 member 1.	Nuclear receptor subfamily 0, group B, member 2a.	0.462
LOC103458516	nr0b2	ENSPREP00000029278	ENSPREP00000013093	Uncharacterized protein.	Nuclear receptor subfamily 0, group B, member 2a.	0.462
LOC103459627	ache	ENSPREP00000020318	ENSPREP00000004407	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.911
LOC103463442	LOC103463443	ENSPREP00000011689	ENSPREP00000011578	Thromboxane A2 receptor.	Thromboxane A2 receptor.	0.900
LOC103463443	LOC103463442	ENSPREP00000011578	ENSPREP00000011689	Thromboxane A2 receptor.	Thromboxane A2 receptor.	0.900
LOC103469672	fgf19	ENSPREP00000001007	ENSPREP00000002527	Fibroblast growth factor receptor.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.880
LOC103473180	Cldn5	ENSPREP00000020548	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
LOC103473180	LOC103479092	ENSPREP00000020548	ENSPREP00000010324	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
LOC103479092	Cldn5	ENSPREP00000010324	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.749
LOC103479092	LOC103473180	ENSPREP00000010324	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
ache	LOC103459627	ENSPREP00000004407	ENSPREP00000020318	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.911
fgf19	LOC103469672	ENSPREP00000002527	ENSPREP00000001007	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.880
fgf19	nr0b2	ENSPREP00000002527	ENSPREP00000013093	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Nuclear receptor subfamily 0, group B, member 2a.	0.577
glra2	glra3	ENSPREP00000002372	ENSPREP00000006026	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.901
glra3	glra2	ENSPREP00000006026	ENSPREP00000002372	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.901
nr0b2	LOC103457349	ENSPREP00000013093	ENSPREP00000015362	Nuclear receptor subfamily 0, group B, member 2a.	Solute carrier family 10 member 1.	0.462
nr0b2	LOC103458516	ENSPREP00000013093	ENSPREP00000029278	Nuclear receptor subfamily 0, group B, member 2a.	Uncharacterized protein.	0.462
nr0b2	fgf19	ENSPREP00000013093	ENSPREP00000002527	Nuclear receptor subfamily 0, group B, member 2a.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.577