STRINGSTRING
Cldn5 Cldn5 vash2 vash2 thbs2 thbs2 adgrb3 adgrb3 vegfc vegfc LOC103467797 LOC103467797 brca1 brca1 cemip cemip LOC103456930 LOC103456930 tnfrsf18 tnfrsf18 DDAH1 DDAH1 adgrb2 adgrb2 tie1 tie1 angptl3 angptl3 ENSPREP00000030584 ENSPREP00000030584 Rgcc Rgcc GREM1 GREM1 fkbpl fkbpl igf2 igf2 wars1 wars1 thbs1 thbs1 htatip2 htatip2 LOC103475437 LOC103475437 vegfd vegfd LOC103472699 LOC103472699 LOC103472698 LOC103472698 LOC103474475 LOC103474475 LOC103477636 LOC103477636 LOC103472688 LOC103472688 LOC103457773 LOC103457773 LOC103457775 LOC103457775 VASH1 VASH1 bmper bmper ENSPREP00000028029 ENSPREP00000028029 adgrb1 adgrb1 sfrp2 sfrp2 ENSPREP00000000130 ENSPREP00000000130 APOH APOH APOH-2 APOH-2 LOC103465321 LOC103465321 gab1 gab1 LOC103464217 LOC103464217 aggf1 aggf1 s1pr1 s1pr1 LOC103471324 LOC103471324 LOC103479190 LOC103479190 LOC103472916 LOC103472916 ENSPREP00000002926 ENSPREP00000002926 LOC103459045 LOC103459045 tnn tnn sash1 sash1 sirt1 sirt1 LOC103477101 LOC103477101 ENSPREP00000004388 ENSPREP00000004388 ENSPREP00000004585 ENSPREP00000004585 LOC103480133 LOC103480133 c5 c5 itgb8 itgb8 LOC103479587 LOC103479587 il10 il10 hgs hgs LOC103464524 LOC103464524 hmga2 hmga2 xbp1 xbp1 ENSPREP00000006768 ENSPREP00000006768 LOC103479015 LOC103479015 rock2 rock2 nfe2l2 nfe2l2 zc3h12a zc3h12a fgf1 fgf1 f3 f3 LOC103457460 LOC103457460 cemip2 cemip2 rock1 rock1 fgf2 fgf2 ENSPREP00000009672 ENSPREP00000009672 ENSPREP00000009700 ENSPREP00000009700 chrna7 chrna7 LOC103471871 LOC103471871 LOC103476642 LOC103476642 ism1 ism1 yjefn3 yjefn3 ENSPREP00000010695 ENSPREP00000010695 aqp1 aqp1 ENSPREP00000010780 ENSPREP00000010780 ctsh ctsh sp1 sp1 LOC103463443 LOC103463443 LOC103463442 LOC103463442 LOC103465116 LOC103465116 hspb1 hspb1 mtdh mtdh sirt2 sirt2 LOC103476047 LOC103476047 ENSPREP00000013232 ENSPREP00000013232 LOC103460095 LOC103460095 LOC103469388 LOC103469388 ENSPREP00000014253 ENSPREP00000014253 ENSPREP00000014507 ENSPREP00000014507 epha2 epha2 LOC103465974 LOC103465974 utp15 utp15 ENSPREP00000015462 ENSPREP00000015462 ENSPREP00000015480 ENSPREP00000015480 LOC103470605 LOC103470605 Adgrg4 Adgrg4 LOC103473699 LOC103473699 tgfbr2 tgfbr2 JMJD8 JMJD8 LOC103479234 LOC103479234 vegfa vegfa LOC103480707 LOC103480707 tnmd tnmd krit1 krit1 mecp2 mecp2 LOC103473747 LOC103473747 LOC103470686 LOC103470686 reck reck cd34 cd34 LOC103463995 LOC103463995 LOC103473180 LOC103473180 tbc1d31 tbc1d31 Pgf Pgf LOC103477924 LOC103477924 LOC103477921 LOC103477921 LOC103477922 LOC103477922 ENSPREP00000021318 ENSPREP00000021318 nf1 nf1 Prok1 Prok1 Vegfb Vegfb tgfb2 tgfb2 LOC103458352 LOC103458352 ecm1 ecm1 LOC103471386 LOC103471386 LOC103478193 LOC103478193 LOC103459727 LOC103459727 LOC103478166 LOC103478166 LOC103478167 LOC103478167 LOC103478178 LOC103478178 mydgf mydgf LOC103479463 LOC103479463 TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
vash2Vasohibin 2. (367 aa)
thbs2Thrombospondin 2a. (1186 aa)
adgrb3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1538 aa)
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
LOC103467797Rap guanine nucleotide exchange factor (GEF) 3. (878 aa)
brca1Uncharacterized protein. (1344 aa)
cemipCell migration inducing hyaluronidase 1. (1321 aa)
LOC103456930Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1707 aa)
tnfrsf18CD40 molecule, TNF receptor superfamily member 5. (314 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (138 aa)
adgrb2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1595 aa)
tie1Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1138 aa)
angptl3Angiopoietin-like 3. (466 aa)
ENSPREP00000030584Cytochrome P450, family 1, subfamily C, polypeptide 2. (479 aa)
RgccRegulator of cell cycle. (134 aa)
GREM1Gremlin. (182 aa)
fkbplFKBP prolyl isomerase like. (356 aa)
igf2IlGF domain-containing protein. (223 aa)
wars1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa)
thbs1Thrombospondin 1a. (1191 aa)
htatip2HIV-1 Tat interactive protein 2. (276 aa)
LOC103475437Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1042 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (286 aa)
LOC103472699Ephrin-A3a; Belongs to the ephrin family. (224 aa)
LOC103472698Ephrin-A1a; Belongs to the ephrin family. (221 aa)
LOC103474475Uncharacterized protein. (342 aa)
LOC103477636Protein S100; Belongs to the S-100 family. (125 aa)
LOC103472688Si:ch211-39a7.1. (576 aa)
LOC103457773Uncharacterized protein. (156 aa)
LOC103457775Elastin microfibril interfacer 1a. (1023 aa)
VASH1Vasohibin 1. (332 aa)
bmperBMP binding endothelial regulator. (685 aa)
ENSPREP00000028029Tetraspanin. (218 aa)
adgrb1Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1524 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
ENSPREP00000000130Uncharacterized protein. (54 aa)
APOHUncharacterized protein. (348 aa)
APOH-2Apolipoprotein H. (363 aa)
LOC103465321Junction plakoglobin a. (721 aa)
gab1GRB2-associated binding protein 1. (756 aa)
LOC103464217Uncharacterized protein. (533 aa)
aggf1Angiogenic factor with G patch and FHA domains 1. (751 aa)
s1pr1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC103471324Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC103479190Chondromodulin. (267 aa)
LOC103472916Dimethylarginine dimethylaminohydrolase 2. (265 aa)
ENSPREP00000002926TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (196 aa)
LOC103459045Chondromodulin. (331 aa)
tnnTenascin N. (845 aa)
sash1SAM and SH3 domain containing 1a. (1155 aa)
sirt1Sirtuin 1. (677 aa)
LOC103477101Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (536 aa)
ENSPREP00000004388Seryl-tRNA synthetase. (435 aa)
ENSPREP00000004585Uncharacterized protein. (196 aa)
LOC103480133Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
c5Anaphylatoxin-like domain-containing protein. (1413 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (762 aa)
LOC103479587Glutamine synthetase. (406 aa)
il10Interleukin 10. (229 aa)
hgsHepatocyte growth factor-regulated tyrosine kinase substrate. (765 aa)
LOC103464524Eph receptor A2 a. (975 aa)
hmga2Uncharacterized protein. (115 aa)
xbp1X-box binding protein 1. (385 aa)
ENSPREP00000006768Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
LOC103479015Fibrinogen C-terminal domain-containing protein. (471 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
nfe2l2Nuclear factor, erythroid 2-like 2a. (617 aa)
zc3h12aZinc finger CCCH-type containing 12A. (623 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
f3Coagulation factor IIIa. (285 aa)
LOC103457460Uncharacterized protein. (209 aa)
cemip2Cell migration inducing hyaluronidase 2. (1389 aa)
rock1Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1263 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ENSPREP00000009672Uncharacterized protein. (343 aa)
ENSPREP00000009700Uncharacterized protein. (280 aa)
chrna7Cholinergic receptor, nicotinic, alpha 7 (neuronal). (483 aa)
LOC103471871Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC103476642Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
ism1Isthmin 1. (505 aa)
yjefn3YjeF N-terminal domain containing 3. (253 aa)
ENSPREP00000010695Elastin microfibril interfacer 2b. (910 aa)
aqp1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
ENSPREP00000010780Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (325 aa)
sp1Sp1 transcription factor. (593 aa)
LOC103463443Thromboxane A2 receptor. (378 aa)
LOC103463442Thromboxane A2 receptor. (379 aa)
LOC103465116Ninjurin 1. (142 aa)
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
mtdhMetadherin a. (519 aa)
sirt2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
LOC103476047Sprouty RTK signaling antagonist 2. (349 aa)
ENSPREP00000013232Uncharacterized protein. (168 aa)
LOC103460095Elastin microfibril interfacer 1b. (1203 aa)
LOC103469388Receptor (G protein-coupled) activity modifying protein 2. (202 aa)
ENSPREP00000014253Uncharacterized protein. (149 aa)
ENSPREP00000014507UBA_6 domain-containing protein. (200 aa)
epha2Eph receptor A2 b. (992 aa)
LOC103465974Adhesion G protein-coupled receptor B1a. (745 aa)
utp15UTP15 small subunit processome component. (528 aa)
ENSPREP00000015462Thrombospondin 1b. (479 aa)
ENSPREP00000015480Uncharacterized protein. (308 aa)
LOC103470605Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
Adgrg4Uncharacterized protein. (121 aa)
LOC103473699Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (356 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
JMJD8Jumonji domain containing 8. (261 aa)
LOC103479234Uncharacterized protein. (291 aa)
vegfaVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
LOC103480707PH domain-containing protein. (763 aa)
tnmdTenomodulin. (296 aa)
krit1KRIT1 ankyrin repeat containing. (739 aa)
mecp2Methyl CpG binding protein 2. (982 aa)
LOC103473747Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (199 aa)
LOC103470686Interleukin-1. (247 aa)
reckReversion-inducing-cysteine-rich protein with kazal motifs. (974 aa)
cd34Uncharacterized protein. (211 aa)
LOC103463995Glutamine synthetase. (373 aa)
LOC103473180Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
tbc1d31TBC1 domain family, member 31. (1060 aa)
PgfPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (152 aa)
LOC103477924G_PROTEIN_RECEP_F1_2 domain-containing protein. (366 aa)
LOC103477921G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
LOC103477922G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
ENSPREP00000021318Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (956 aa)
nf1Neurofibromin 1b. (2742 aa)
Prok1Prokineticin 1. (100 aa)
VegfbVascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (94 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOC103458352SAM and SH3 domain containing 1b. (1060 aa)
ecm1Uncharacterized protein. (482 aa)
LOC103471386Uncharacterized protein. (535 aa)
LOC103478193Uncharacterized protein. (433 aa)
LOC103459727Uncharacterized protein. (169 aa)
LOC103478166Ephrin-A3b; Belongs to the ephrin family. (221 aa)
LOC103478167Ephrin-A1b; Belongs to the ephrin family. (232 aa)
LOC103478178Uncharacterized protein. (621 aa)
mydgfMyeloid-derived growth factor. (160 aa)
LOC103479463Sirtuin 6. (339 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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