(33 nodes) Negative regulation of DNA recombination network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	terf2	HTH myb-type domain-containing protein. (635 aa)
	parp3	Poly [ADP-ribose] polymerase. (522 aa)
	ENSPREP00000012769	H15 domain-containing protein. (114 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1180 aa)
	zranb3	Zinc finger, RAN-binding domain containing 3. (1098 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	blm	BLM RecQ like helicase. (1399 aa)
	ENSPREP00000011174	H15 domain-containing protein. (163 aa)
	ankle1	Zgc:85936. (834 aa)
	LOC103456865	Structural maintenance of chromosomes flexible hinge domain containing 1. (1677 aa)
	LOC103456942	Structural maintenance of chromosomes flexible hinge domain containing 1. (1673 aa)
	parpbp	PARP1 binding protein. (589 aa)
	thoc1	THO complex 1. (654 aa)
	LOC103459359	H15 domain-containing protein. (200 aa)
	LOC103459356	H15 domain-containing protein. (211 aa)
	terf2ip	BRCT domain-containing protein. (705 aa)
	ENSPREP00000009051	H15 domain-containing protein. (113 aa)
	ENSPREP00000008919	H15 domain-containing protein. (111 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	fancb	FA complementation group B. (869 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1380 aa)
	radx	RPA1 related single stranded DNA binding protein. (818 aa)
	rif1	Replication timing regulatory factor 1. (2323 aa)
	ENSPREP00000026819	Si:ch211-103n10.5. (155 aa)
	ENSPREP00000026680	H1 histone family, member 0. (195 aa)
	ENSPREP00000026167	F-box DNA helicase 1. (875 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1579 aa)
	LOC103470781	Uncharacterized protein. (224 aa)
	recql5	RecQ helicase-like 5. (1020 aa)
	LOC103480977	Uncharacterized protein. (807 aa)
	shld2	Si:ch211-134m17.9. (532 aa)
	msh3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1117 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009051	ENSPREP00000026680	ENSPREP00000009051	ENSPREP00000026680	H15 domain-containing protein.	H1 histone family, member 0.	0.494
ENSPREP00000012769	ENSPREP00000026680	ENSPREP00000012769	ENSPREP00000026680	H15 domain-containing protein.	H1 histone family, member 0.	0.535
ENSPREP00000026167	blm	ENSPREP00000026167	ENSPREP00000011311	F-box DNA helicase 1.	BLM RecQ like helicase.	0.928
ENSPREP00000026167	mlh1	ENSPREP00000026167	ENSPREP00000002003	F-box DNA helicase 1.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.741
ENSPREP00000026167	msh2	ENSPREP00000026167	ENSPREP00000007571	F-box DNA helicase 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.478
ENSPREP00000026167	msh3	ENSPREP00000026167	ENSPREP00000018450	F-box DNA helicase 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.478
ENSPREP00000026167	msh6	ENSPREP00000026167	ENSPREP00000034111	F-box DNA helicase 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.514
ENSPREP00000026167	recql5	ENSPREP00000026167	ENSPREP00000023314	F-box DNA helicase 1.	RecQ helicase-like 5.	0.906
ENSPREP00000026167	rtel1	ENSPREP00000026167	ENSPREP00000012657	F-box DNA helicase 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.514
ENSPREP00000026167	tp53bp1	ENSPREP00000026167	ENSPREP00000025854	F-box DNA helicase 1.	Tumor protein p53 binding protein, 1.	0.663
ENSPREP00000026167	zranb3	ENSPREP00000026167	ENSPREP00000012031	F-box DNA helicase 1.	Zinc finger, RAN-binding domain containing 3.	0.624
ENSPREP00000026680	ENSPREP00000009051	ENSPREP00000026680	ENSPREP00000009051	H1 histone family, member 0.	H15 domain-containing protein.	0.494
ENSPREP00000026680	ENSPREP00000012769	ENSPREP00000026680	ENSPREP00000012769	H1 histone family, member 0.	H15 domain-containing protein.	0.535
ENSPREP00000026680	ENSPREP00000026819	ENSPREP00000026680	ENSPREP00000026819	H1 histone family, member 0.	Si:ch211-103n10.5.	0.635
ENSPREP00000026819	ENSPREP00000026680	ENSPREP00000026819	ENSPREP00000026680	Si:ch211-103n10.5.	H1 histone family, member 0.	0.635
ENSPREP00000026819	LOC103459356	ENSPREP00000026819	ENSPREP00000009336	Si:ch211-103n10.5.	H15 domain-containing protein.	0.427
LOC103459356	ENSPREP00000026819	ENSPREP00000009336	ENSPREP00000026819	H15 domain-containing protein.	Si:ch211-103n10.5.	0.427
LOC103470781	shld2	ENSPREP00000025586	ENSPREP00000018657	Uncharacterized protein.	Si:ch211-134m17.9.	0.939
blm	ENSPREP00000026167	ENSPREP00000011311	ENSPREP00000026167	BLM RecQ like helicase.	F-box DNA helicase 1.	0.928
blm	mlh1	ENSPREP00000011311	ENSPREP00000002003	BLM RecQ like helicase.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.977