(112 nodes) Positive regulation of growth network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rnf157	Ring finger protein 157. (701 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (418 aa)
	klhl22	Kelch-like family member 22. (673 aa)
	LOC103472214	Raftlin, lipid raft linker 1a. (699 aa)
	parp2	Poly [ADP-ribose] polymerase. (647 aa)
	LOC103468055	Uncharacterized protein. (1292 aa)
	slc44a4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (718 aa)
	akap6	A kinase (PRKA) anchor protein 6. (2553 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1350 aa)
	LOC103471028	COMM domain containing 5. (203 aa)
	LOC103469840	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (234 aa)
	LOC103477855	Uncharacterized protein. (678 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1057 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	LOC103470450	Si:dkey-40c11.2. (812 aa)
	LOC103474759	Somatolactin alpha. (231 aa)
	LOC103467654	Synaptotagmin IIa. (430 aa)
	ENSPREP00000007409	NGF domain-containing protein; Belongs to the NGF-beta family. (273 aa)
	LOC103469263	Parvalbumin 8; Belongs to the parvalbumin family. (109 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (742 aa)
	SRF	Serum response factor. (243 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (276 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	n6amt1	N-6 adenine-specific DNA methyltransferase 1. (218 aa)
	adnp2	ADNP homeobox 2b. (1014 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	mkks	McKusick-Kaufman syndrome. (576 aa)
	spast	Spastin; Belongs to the AAA ATPase family. (488 aa)
	nsmf	NMDA receptor synaptonuclear signaling and neuronal migration factor a. (623 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	dbnl	Drebrin-like b. (479 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
	LOC103469368	Rho family GTPase 2. (235 aa)
	LOC103462612	Uncharacterized protein; Belongs to the semaphorin family. (615 aa)
	ENSPREP00000012400	Uncharacterized protein. (550 aa)
	edn1	Endothelin 1. (207 aa)
	srf	Serum response factor b. (570 aa)
	extl3	Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (914 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	exosc4	Exosome component 4. (245 aa)
	ENSPREP00000014353	Semaphorin 7A; Belongs to the semaphorin family. (366 aa)
	LOC103476935	ZP domain-containing protein. (392 aa)
	ENSPREP00000014929	Wolfram syndrome 1a (wolframin). (784 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ddx49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family. (475 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	agrn	Agrin. (1768 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
	LOC103458418	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	fxn	Frataxin. (213 aa)
	SYT2	Synaptotagmin 2. (413 aa)
	dbn1	Drebrin 1. (528 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	rufy3	RUN and FYVE domain containing 3. (660 aa)
	ENSPREP00000019994	Uncharacterized protein. (95 aa)
	ino80	INO80 complex ATPase subunit. (1484 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (427 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	exosc2	Exosome component 2. (293 aa)
	ENSPREP00000021170	Uncharacterized protein. (167 aa)
	Zpr1	ZPR1 zinc finger. (446 aa)
	LOC103469569	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (472 aa)
	supv3l1	SUV3-like helicase. (760 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	ENSPREP00000022056	Si:dkey-280e21.3. (351 aa)
	LOC103466445	ADAM metallopeptidase domain 10b. (781 aa)
	LOC103466036	ZP domain-containing protein. (423 aa)
	ENSPREP00000022415	FGFR1 oncogene partner. (395 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	LOC103460487	Fibronectin 1a. (2502 aa)
	LOC103467541	Colony stimulating factor 1b (macrophage). (266 aa)
	zfpm2	Zinc finger protein, FOG family member 2a. (1168 aa)
	trim32	Tripartite motif containing 32. (628 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	LOC103462971	CDKN2A interacting protein. (317 aa)
	LOC103461763	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (871 aa)
	LOC103465401	GLUCAGON domain-containing protein. (195 aa)
	rusc1	RUN and SH3 domain containing 1. (655 aa)
	LOC103476861	Leucine-rich, glioma inactivated 1a. (554 aa)
	CDKL5	Cyclin dependent kinase like 5. (967 aa)
	ucn	Urotensin 1. (147 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (969 aa)
	ENSPREP00000027456	Shootin 1. (279 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (195 aa)
	LOC103462918	Ig-like domain-containing protein. (693 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103477638	Si:ch211-113g11.6; Belongs to the semaphorin family. (609 aa)
	LOC103462031	Cyclin-dependent kinase-like 5. (1144 aa)
	LOC103467432	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (286 aa)
	plaa	Phospholipase A2-activating protein. (797 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	LOC103467401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	l1cam	L1 cell adhesion molecule, paralog a. (1274 aa)
	LOC103481238	Synaptotagmin Vb. (424 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	LOC103481273	Rho family GTPase 2. (230 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)
	ist1	IST1 factor associated with ESCRT-III. (333 aa)
	lgi1	Leucine-rich, glioma inactivated 1b. (576 aa)
	golga4	Golgin A4. (1963 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)
	adam10	Uncharacterized protein. (645 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
ENSPREP00000007409	LOC103467432	ENSPREP00000007409	ENSPREP00000029097	NGF domain-containing protein; Belongs to the NGF-beta family.	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	0.905
ENSPREP00000007409	igf1	ENSPREP00000007409	ENSPREP00000010429	NGF domain-containing protein; Belongs to the NGF-beta family.	Insulin-like growth factor 1.	0.400
ENSPREP00000012400	bbs4	ENSPREP00000012400	ENSPREP00000009421	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.479
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000016378	rptor	ENSPREP00000016378	ENSPREP00000004520	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Regulatory associated protein of MTOR, complex 1.	0.987
ENSPREP00000020277	fxn	ENSPREP00000020277	ENSPREP00000018219	RBR-type E3 ubiquitin transferase.	Frataxin.	0.468
ENSPREP00000020277	mul1	ENSPREP00000020277	ENSPREP00000031865	RBR-type E3 ubiquitin transferase.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.690
ENSPREP00000021170	LOC103458418	ENSPREP00000021170	ENSPREP00000018181	Uncharacterized protein.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.430
ENSPREP00000021170	LOC103465401	ENSPREP00000021170	ENSPREP00000025838	Uncharacterized protein.	GLUCAGON domain-containing protein.	0.538
ENSPREP00000021170	bcl2	ENSPREP00000021170	ENSPREP00000006116	Uncharacterized protein.	BCL2 apoptosis regulator b.	0.541
ENSPREP00000021170	edn1	ENSPREP00000021170	ENSPREP00000012837	Uncharacterized protein.	Endothelin 1.	0.470
ENSPREP00000021170	igf1	ENSPREP00000021170	ENSPREP00000010429	Uncharacterized protein.	Insulin-like growth factor 1.	0.549
ENSPREP00000021170	igf2	ENSPREP00000021170	ENSPREP00000029568	Uncharacterized protein.	IlGF domain-containing protein.	0.445
ENSPREP00000021987	Adam17	ENSPREP00000021987	ENSPREP00000021960	ADAM metallopeptidase domain 17b.	Pep_M12B_propep domain-containing protein.	0.932
ENSPREP00000022056	LOC103468055	ENSPREP00000022056	ENSPREP00000002930	Si:dkey-280e21.3.	Uncharacterized protein.	0.419
ENSPREP00000022056	l1cam	ENSPREP00000022056	ENSPREP00000032193	Si:dkey-280e21.3.	L1 cell adhesion molecule, paralog a.	0.419
ENSPREP00000027456	LOC103468055	ENSPREP00000027456	ENSPREP00000002930	Shootin 1.	Uncharacterized protein.	0.419
ENSPREP00000027456	l1cam	ENSPREP00000027456	ENSPREP00000032193	Shootin 1.	L1 cell adhesion molecule, paralog a.	0.419