(58 nodes) Positive regulation of JNK cascade network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103456513	Uncharacterized protein. (883 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	ankrd6	Ankyrin repeat domain 6. (768 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103478343	Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (1134 aa)
	LOC103459868	SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
	LOC103469798	SCY domain-containing protein. (110 aa)
	ENSPREP00000004374	Protein kinase domain-containing protein. (88 aa)
	ENSPREP00000004399	CNH domain-containing protein. (225 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	taok3	TAO kinase 3a. (950 aa)
	LOC103476580	Dual specificity phosphatase 19b. (202 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (996 aa)
	axin1	Axin 1. (850 aa)
	rb1cc1	RB1-inducible coiled-coil 1. (1616 aa)
	traf4	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC103467575	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	LOC103475599	TAO kinase 1b. (1015 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (477 aa)
	LOC103474167	TAO kinase 1a. (1013 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (884 aa)
	map4k4	Mitogen-activated protein kinase kinase kinase kinase 4. (1114 aa)
	LOC103457029	TRAF2 and NCK interacting kinase b. (179 aa)
	ENSPREP00000016282	TRAF2 and NCK interacting kinase b. (498 aa)
	LOC103469511	TAO kinase 2. (1086 aa)
	LOC103465913	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	ENSPREP00000018072	Uncharacterized protein. (672 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1028 aa)
	ENSPREP00000018325	Protein kinase domain-containing protein. (176 aa)
	ENSPREP00000018467	CNH domain-containing protein. (518 aa)
	tpd52l1	Tpd52 like 1. (188 aa)
	sh3rf3	SH3 domain containing ring finger 3. (815 aa)
	ENSPREP00000018701	Ectodysplasin A receptor. (385 aa)
	ENSPREP00000019024	TAO kinase 3b. (437 aa)
	ENSPREP00000019040	Uncharacterized protein. (93 aa)
	ENSPREP00000019402	Protein kinase domain-containing protein. (201 aa)
	mbip	MAP3K12 binding inhibitory protein 1. (334 aa)
	LOC103469572	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC103473816	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	gadd45g	Growth arrest and DNA-damage-inducible, gamma a. (159 aa)
	LOC103470783	CARD domain-containing protein. (434 aa)
	ncf1	Neutrophil cytosolic factor 1. (438 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (418 aa)
	sh3rf1	SH3 domain containing ring finger 1. (849 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC103473320	TNF receptor-associated factor. (494 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	znf622	Zinc finger protein 622. (459 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
	dusp19	Dual specificity phosphatase 19a. (209 aa)
	LOC103457268	Si:ch211-108d22.2. (2793 aa)
	mink1	Misshapen-like kinase 1. (1255 aa)
	taok2	TAO kinase 2b. (1168 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004399	ENSPREP00000018325	ENSPREP00000004399	ENSPREP00000018325	CNH domain-containing protein.	Protein kinase domain-containing protein.	0.899
ENSPREP00000016282	ENSPREP00000018325	ENSPREP00000016282	ENSPREP00000018325	TRAF2 and NCK interacting kinase b.	Protein kinase domain-containing protein.	0.899
ENSPREP00000018072	LOC103470783	ENSPREP00000018072	ENSPREP00000025510	Uncharacterized protein.	CARD domain-containing protein.	0.531
ENSPREP00000018072	ripk2	ENSPREP00000018072	ENSPREP00000009886	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.808
ENSPREP00000018072	traf6	ENSPREP00000018072	ENSPREP00000005082	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.541
ENSPREP00000018325	ENSPREP00000004399	ENSPREP00000018325	ENSPREP00000004399	Protein kinase domain-containing protein.	CNH domain-containing protein.	0.899
ENSPREP00000018325	ENSPREP00000016282	ENSPREP00000018325	ENSPREP00000016282	Protein kinase domain-containing protein.	TRAF2 and NCK interacting kinase b.	0.899
ENSPREP00000018325	ENSPREP00000018467	ENSPREP00000018325	ENSPREP00000018467	Protein kinase domain-containing protein.	CNH domain-containing protein.	0.899
ENSPREP00000018325	LOC103457029	ENSPREP00000018325	ENSPREP00000016224	Protein kinase domain-containing protein.	TRAF2 and NCK interacting kinase b.	0.899
ENSPREP00000018467	ENSPREP00000018325	ENSPREP00000018467	ENSPREP00000018325	CNH domain-containing protein.	Protein kinase domain-containing protein.	0.899
ENSPREP00000018701	sh3rf3	ENSPREP00000018701	ENSPREP00000018669	Ectodysplasin A receptor.	SH3 domain containing ring finger 3.	0.546
ENSPREP00000019024	ENSPREP00000019040	ENSPREP00000019024	ENSPREP00000019040	TAO kinase 3b.	Uncharacterized protein.	0.686
ENSPREP00000019040	ENSPREP00000019024	ENSPREP00000019040	ENSPREP00000019024	Uncharacterized protein.	TAO kinase 3b.	0.686
ENSPREP00000019402	map2k4	ENSPREP00000019402	ENSPREP00000026466	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.901
ENSPREP00000019402	map2k7	ENSPREP00000019402	ENSPREP00000027032	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 7.	0.732
ENSPREP00000019402	ripk2	ENSPREP00000019402	ENSPREP00000009886	Protein kinase domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.567
ENSPREP00000019402	traf6	ENSPREP00000019402	ENSPREP00000005082	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.611
GADD45B	map2k7	ENSPREP00000001108	ENSPREP00000027032	Growth arrest and DNA damage inducible beta.	Mitogen-activated protein kinase kinase 7.	0.673
LOC103456513	axin1	ENSPREP00000000160	ENSPREP00000012177	Uncharacterized protein.	Axin 1.	0.902
LOC103457029	ENSPREP00000018325	ENSPREP00000016224	ENSPREP00000018325	TRAF2 and NCK interacting kinase b.	Protein kinase domain-containing protein.	0.899