(19 nodes) Regulation of alpha-beta T cell proliferation network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	sh3rf1	SH3 domain containing ring finger 1. (849 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	TGFBR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
	IL18	Uncharacterized protein. (218 aa)
	LOC103464828	E3 ubiquitin-protein ligase. (869 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1230 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	ENSPREP00000013399	Uncharacterized protein. (453 aa)
	LOC103468233	Tyrosine-protein kinase. (606 aa)
	ENSPREP00000010806	Galectin. (325 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	syk	Tyrosine-protein kinase. (614 aa)
	LOC103475332	Interferon regulatory factor. (291 aa)
	itch	E3 ubiquitin-protein ligase. (840 aa)
	vsir	V-set immunoregulatory receptor. (291 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	Galectin.	Uncharacterized protein.	0.491
ENSPREP00000010806	ptprc	ENSPREP00000010806	ENSPREP00000018309	Galectin.	Protein tyrosine phosphatase receptor type C.	0.591
ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	Uncharacterized protein.	Galectin.	0.491
ENSPREP00000013399	ptprc	ENSPREP00000013399	ENSPREP00000018309	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.478
ENSPREP00000027430	LOC103468233	ENSPREP00000027430	ENSPREP00000012417	CARD domain-containing protein.	Tyrosine-protein kinase.	0.511
ENSPREP00000027430	LOC103468544	ENSPREP00000027430	ENSPREP00000027446	CARD domain-containing protein.	Guanylate kinase-like domain-containing protein.	0.900
ENSPREP00000027430	ripk2	ENSPREP00000027430	ENSPREP00000009886	CARD domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
ENSPREP00000027430	syk	ENSPREP00000027430	ENSPREP00000006334	CARD domain-containing protein.	Tyrosine-protein kinase.	0.478
ENSPREP00000030326	LOC103461485	ENSPREP00000030326	ENSPREP00000010220	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.902
LOC103461485	ENSPREP00000030326	ENSPREP00000010220	ENSPREP00000030326	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.902
LOC103464828	itch	ENSPREP00000023584	ENSPREP00000001984	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC103464828	ripk2	ENSPREP00000023584	ENSPREP00000009886	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.573
LOC103468233	ENSPREP00000027430	ENSPREP00000012417	ENSPREP00000027430	Tyrosine-protein kinase.	CARD domain-containing protein.	0.511
LOC103468233	LOC103468544	ENSPREP00000012417	ENSPREP00000027446	Tyrosine-protein kinase.	Guanylate kinase-like domain-containing protein.	0.511
LOC103468544	ENSPREP00000027430	ENSPREP00000027446	ENSPREP00000027430	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
LOC103468544	LOC103468233	ENSPREP00000027446	ENSPREP00000012417	Guanylate kinase-like domain-containing protein.	Tyrosine-protein kinase.	0.511
LOC103468544	ripk2	ENSPREP00000027446	ENSPREP00000009886	Guanylate kinase-like domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
LOC103468544	syk	ENSPREP00000027446	ENSPREP00000006334	Guanylate kinase-like domain-containing protein.	Tyrosine-protein kinase.	0.478
LOC103475332	ptprc	ENSPREP00000005624	ENSPREP00000018309	Interferon regulatory factor.	Protein tyrosine phosphatase receptor type C.	0.430
TGFBR2	tgfbr2	ENSPREP00000026860	ENSPREP00000016340	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902