(113 nodes) Protein autophosphorylation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479184	Protein kinase domain-containing protein. (292 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	sik2	Salt-inducible kinase 2b. (930 aa)
	LOC103481853	Apoptosis-associated tyrosine kinase b. (1652 aa)
	LOC103463153	Si:ch73-60h1.1; Belongs to the protein kinase superfamily. (479 aa)
	ENSPREP00000002203	Unc-51 like autophagy activating kinase 1a. (587 aa)
	fes	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (824 aa)
	pim2	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (302 aa)
	riok2	RIO kinase 2 (yeast). (520 aa)
	LOC103472579	STE20-like kinase b. (1004 aa)
	LOC103468819	Apoptosis-associated tyrosine kinase a. (1570 aa)
	pim1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103464872	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (376 aa)
	LOC103471249	CDC-like kinase 4a. (515 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (767 aa)
	syk	Tyrosine-protein kinase. (614 aa)
	eif2ak1	Eukaryotic translation initiation factor 2-alpha kinase 1. (660 aa)
	LOC103475402	Serine/threonine kinase 10. (717 aa)
	fgr	Tyrosine-protein kinase. (534 aa)
	ENSPREP00000007305	Tyrosine-protein kinase receptor. (512 aa)
	lmtk2	Lemur tyrosine kinase 2. (1509 aa)
	LOC103479030	Discoidin domain receptor tyrosine kinase 2b. (894 aa)
	Mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (376 aa)
	ddr2	Discoidin domain receptor tyrosine kinase 2a. (864 aa)
	LOC103458062	Serine/threonine kinase 24. (437 aa)
	LOC103466654	Tyrosine-protein kinase receptor. (1415 aa)
	LOC103479062	Eph receptor B3a. (959 aa)
	LOC103479635	Death domain-containing protein. (536 aa)
	melk	Non-specific serine/threonine protein kinase. (601 aa)
	ulk1	Unc-51 like autophagy activating kinase 1. (1024 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1072 aa)
	aak1	AP2 associated kinase 1a. (1055 aa)
	ephb3	Receptor protein-tyrosine kinase. (1013 aa)
	stk39	Serine threonine kinase 39. (504 aa)
	ENSPREP00000010734	Uncharacterized protein. (93 aa)
	nek2	NIMA-related kinase 2. (352 aa)
	stk25	Serine/threonine kinase 25b. (428 aa)
	YES1	Tyrosine-protein kinase. (454 aa)
	LOC103477270	Uncharacterized protein. (689 aa)
	ENSPREP00000011628	Uncharacterized protein. (564 aa)
	LOC103477355	Protein kinase domain-containing protein. (582 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	LOC103465114	WNK lysine deficient protein kinase 2. (2243 aa)
	ulk3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (494 aa)
	rb1cc1	RB1-inducible coiled-coil 1. (1616 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	LOC103468233	Tyrosine-protein kinase. (606 aa)
	LOC103462605	Tyrosine-protein kinase receptor. (1403 aa)
	dapk2	Death-associated protein kinase 2b; Belongs to the protein kinase superfamily. (390 aa)
	LOC103460106	Protein kinase domain-containing protein. (99 aa)
	LOC103460129	Protein kinase domain-containing protein. (195 aa)
	LOC103477297	VRK serine/threonine kinase 2. (581 aa)
	ptk2	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (878 aa)
	ENSPREP00000014417	WNK lysine deficient protein kinase 2. (1538 aa)
	LOC103467077	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1132 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1008 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (425 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	LOC103473710	AP2 associated kinase 1b. (1079 aa)
	smg1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3658 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	LOC103458433	Non-specific serine/threonine protein kinase. (507 aa)
	LOC103469510	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (452 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
	LOC103475221	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (942 aa)
	LOC103472469	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1080 aa)
	LOC103474222	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (724 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (423 aa)
	LOC103471921	Si:dkey-240h12.4; Belongs to the protein kinase superfamily. (397 aa)
	LOC103480673	Serine/threonine protein kinase 26. (472 aa)
	ddr1	Discoidin domain receptor tyrosine kinase 1. (1000 aa)
	slk	STE20-like kinase a. (1157 aa)
	uhmk1	U2AF homology motif (UHM) kinase 1. (443 aa)
	insr	Insulin receptor a. (1178 aa)
	dapk3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
	stk24	Serine/threonine kinase 24b (STE20 homolog, yeast). (432 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (528 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	LOC103479892	Tyrosine-protein kinase. (473 aa)
	LOC103481136	FAM20C golgi associated secretory pathway kinase. (526 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1055 aa)
	chek2	Checkpoint kinase 2. (510 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	pask	PAS domain containing serine/threonine kinase. (1211 aa)
	LOC103458875	Tyrosine-protein kinase receptor. (1453 aa)
	dapk1	Death-associated protein kinase 1. (1444 aa)
	LOC108165961	F-BAR domain-containing protein. (174 aa)
	ENSPREP00000024937	SH2 domain-containing protein. (152 aa)
	ENSPREP00000024995	Protein kinase domain-containing protein. (161 aa)
	ENSPREP00000025003	Uncharacterized protein. (394 aa)
	pikfyve	Phosphoinositide kinase, FYVE finger containing. (2073 aa)
	LOC103465075	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (413 aa)
	LOC103478721	Protein kinase domain-containing protein. (271 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	prkx	Protein kinase X-linked. (356 aa)
	CDKL5	Cyclin dependent kinase like 5. (967 aa)
	LOC103478814	Protein kinase domain-containing protein. (647 aa)
	LOC103470814	Discoidin domain receptor family, member 2, like. (906 aa)
	clk2	CDC-like kinase 2a. (525 aa)
	epha8	Uncharacterized protein. (1031 aa)
	LOC103457606	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (994 aa)
	LOC103462031	Cyclin-dependent kinase-like 5. (1144 aa)
	flt1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1274 aa)
	htatip2	HIV-1 Tat interactive protein 2. (276 aa)
	stk16	Serine/threonine kinase 16. (297 aa)
	ENSPREP00000029585	SH3 domain-containing protein. (137 aa)
	LOC103461925	PTK6 protein tyrosine kinase 6b. (407 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	LOC103456562	Oxidative stress responsive kinase 1b. (543 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	ENSPREP00000011628	ENSPREP00000030055	ENSPREP00000011628	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.425
EIF2AK4	ENSPREP00000016378	ENSPREP00000030055	ENSPREP00000016378	Eukaryotic translation initiation factor 2 alpha kinase 4.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.520
EIF2AK4	LOC103477270	ENSPREP00000030055	ENSPREP00000011565	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.425
EIF2AK4	LOC103477355	ENSPREP00000030055	ENSPREP00000011646	Eukaryotic translation initiation factor 2 alpha kinase 4.	Protein kinase domain-containing protein.	0.425
EIF2AK4	Mtor	ENSPREP00000030055	ENSPREP00000016474	Eukaryotic translation initiation factor 2 alpha kinase 4.	Serine/threonine-protein kinase TOR.	0.520
EIF2AK4	eif2ak3	ENSPREP00000030055	ENSPREP00000009940	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.545
ENSPREP00000002203	ENSPREP00000016378	ENSPREP00000002203	ENSPREP00000016378	Unc-51 like autophagy activating kinase 1a.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.841
ENSPREP00000002203	LOC103466013	ENSPREP00000002203	ENSPREP00000021307	Unc-51 like autophagy activating kinase 1a.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.526
ENSPREP00000002203	LOC103479635	ENSPREP00000002203	ENSPREP00000009477	Unc-51 like autophagy activating kinase 1a.	Death domain-containing protein.	0.470
ENSPREP00000002203	Mtor	ENSPREP00000002203	ENSPREP00000016474	Unc-51 like autophagy activating kinase 1a.	Serine/threonine-protein kinase TOR.	0.841
ENSPREP00000002203	melk	ENSPREP00000002203	ENSPREP00000009683	Unc-51 like autophagy activating kinase 1a.	Non-specific serine/threonine protein kinase.	0.527
ENSPREP00000002203	rb1cc1	ENSPREP00000002203	ENSPREP00000012221	Unc-51 like autophagy activating kinase 1a.	RB1-inducible coiled-coil 1.	0.947
ENSPREP00000002203	smg1	ENSPREP00000002203	ENSPREP00000016434	Unc-51 like autophagy activating kinase 1a.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.639
ENSPREP00000007305	ENSPREP00000025003	ENSPREP00000007305	ENSPREP00000025003	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.473
ENSPREP00000007305	LOC103461925	ENSPREP00000007305	ENSPREP00000029659	Tyrosine-protein kinase receptor.	PTK6 protein tyrosine kinase 6b.	0.415
ENSPREP00000011628	EIF2AK4	ENSPREP00000011628	ENSPREP00000030055	Uncharacterized protein.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.425
ENSPREP00000011628	eif2ak1	ENSPREP00000011628	ENSPREP00000006700	Uncharacterized protein.	Eukaryotic translation initiation factor 2-alpha kinase 1.	0.468
ENSPREP00000016378	EIF2AK4	ENSPREP00000016378	ENSPREP00000030055	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.520
ENSPREP00000016378	ENSPREP00000002203	ENSPREP00000016378	ENSPREP00000002203	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Unc-51 like autophagy activating kinase 1a.	0.841
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934