(91 nodes) Regulation of lipid biosynthetic process network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (427 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (821 aa)
	LOC103476211	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (229 aa)
	LOC103467776	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	ormdl1	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	LOC103475277	ATP-binding cassette, sub-family G (WHITE), member 1. (620 aa)
	LOC103466252	Dickkopf WNT signaling pathway inhibitor 3b. (257 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	LOC103481463	START domain-containing protein. (272 aa)
	sirt1	Sirtuin 1. (677 aa)
	SAMD8	Sterile alpha motif domain containing 8. (408 aa)
	sf1	Splicing factor 1. (676 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (572 aa)
	slc27a1	Solute carrier family 27 member 1a. (648 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1207 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	apob	Apolipoprotein Ba. (4338 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (466 aa)
	LOC103457447	Apolipoprotein Bb, tandem duplicate 2. (3356 aa)
	ENSPREP00000010257	Uncharacterized protein. (434 aa)
	ENSPREP00000010344	Vitellogenin domain-containing protein. (759 aa)
	LOC103479424	MID1 interacting protein 1a. (134 aa)
	cnep1r1	CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
	sphk2	Sphingosine kinase 2. (820 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
	LOC103474828	Apolipoprotein A-Ib. (263 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (368 aa)
	abcd2	ATP-binding cassette, sub-family D (ALD), member 2. (790 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (307 aa)
	SNAI2	Snail family transcriptional repressor 2. (272 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (667 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
	LOC103481157	MID1 interacting protein 1. (146 aa)
	armc5	Armadillo repeat containing 5. (841 aa)
	DGKQ	Diacylglycerol kinase. (895 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (765 aa)
	LOC103481706	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (464 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (472 aa)
	LOC103470686	Interleukin-1. (247 aa)
	podn	Podocan. (587 aa)
	ctdnep1	CTD nuclear envelope phosphatase 1b. (248 aa)
	LOC103477493	Zgc:153896. (449 aa)
	ENSPREP00000021170	Uncharacterized protein. (167 aa)
	LOC103464789	Tribbles pseudokinase 3. (351 aa)
	LOC103475016	Thyroid hormone responsive. (134 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (490 aa)
	abhd6	Abhydrolase domain containing 6b. (324 aa)
	SPHK1	Sphingosine kinase 1. (564 aa)
	Srebf2	Uncharacterized protein. (209 aa)
	ENSPREP00000024568	BHLH domain-containing protein. (197 aa)
	ENSPREP00000025121	Sirtuin 3. (152 aa)
	ENSPREP00000025671	Lysophosphatidylcholine acyltransferase 1. (490 aa)
	LOC103466083	Si:dkey-103i16.6. (445 aa)
	rusc1	RUN and SH3 domain containing 1. (655 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	Gper1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	ENSPREP00000027898	cAMP responsive element binding protein-like 2. (113 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (542 aa)
	ENSPREP00000029374	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (380 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	SPHK1-2	Sphingosine kinase 1. (367 aa)
	ENSPREP00000029606	G_PROTEIN_RECEP_F2_4 domain-containing protein. (267 aa)
	scap	SREBF chaperone. (1264 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (127 aa)
	ccn1	Cellular communication network factor 1. (536 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (496 aa)
	LOC103464284	Abhydrolase domain containing 6. (335 aa)
	fam3a	Family with sequence similarity 3 member A. (225 aa)
	LOC103476985	SAM domain-containing protein. (431 aa)
	brca1	Uncharacterized protein. (1344 aa)
	abcg4	ATP-binding cassette, sub-family G (WHITE), member 4a. (649 aa)
	LOC103462479	Dickkopf WNT signaling pathway inhibitor 3a. (275 aa)
	zbtb20	Zinc finger and BTB domain containing 20. (678 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENPP7	LOC103477493	ENSPREP00000018975	ENSPREP00000020871	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Zgc:153896.	0.903
ENPP7	asah1	ENSPREP00000018975	ENSPREP00000000094	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.692
ENSPREP00000006768	fgf19	ENSPREP00000006768	ENSPREP00000002527	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.487
ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	Uncharacterized protein.	Vitellogenin domain-containing protein.	0.739
ENSPREP00000010257	ENSPREP00000030224	ENSPREP00000010257	ENSPREP00000030224	Uncharacterized protein.	PID domain-containing protein.	0.475
ENSPREP00000010257	LOC103473017	ENSPREP00000010257	ENSPREP00000013094	Uncharacterized protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010257	LOC103474828	ENSPREP00000010257	ENSPREP00000010904	Uncharacterized protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010257	LOC103477848	ENSPREP00000010257	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.757
ENSPREP00000010257	scarb1	ENSPREP00000010257	ENSPREP00000021860	Uncharacterized protein.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.727
ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	Vitellogenin domain-containing protein.	Uncharacterized protein.	0.739
ENSPREP00000010344	ENSPREP00000030224	ENSPREP00000010344	ENSPREP00000030224	Vitellogenin domain-containing protein.	PID domain-containing protein.	0.475
ENSPREP00000010344	LOC103473017	ENSPREP00000010344	ENSPREP00000013094	Vitellogenin domain-containing protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010344	LOC103474828	ENSPREP00000010344	ENSPREP00000010904	Vitellogenin domain-containing protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010344	LOC103477848	ENSPREP00000010344	ENSPREP00000006664	Vitellogenin domain-containing protein.	Apolipoprotein Eb.	0.757
ENSPREP00000010344	scarb1	ENSPREP00000010344	ENSPREP00000021860	Vitellogenin domain-containing protein.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.727
ENSPREP00000016378	LOC103464789	ENSPREP00000016378	ENSPREP00000021574	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Tribbles pseudokinase 3.	0.546
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000016378	sirt1	ENSPREP00000016378	ENSPREP00000003960	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Sirtuin 1.	0.585
ENSPREP00000021170	LOC103470686	ENSPREP00000021170	ENSPREP00000019387	Uncharacterized protein.	Interleukin-1.	0.525
ENSPREP00000021170	igf2	ENSPREP00000021170	ENSPREP00000029568	Uncharacterized protein.	IlGF domain-containing protein.	0.445