(54 nodes) Mesoderm morphogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	tll1	Metalloendopeptidase. (1027 aa)
	ENSPREP00000000130	Uncharacterized protein. (54 aa)
	Tal1	BHLH domain-containing protein. (124 aa)
	LOC103477157	Dishevelled-binding antagonist of beta-catenin 2. (835 aa)
	LOC103475867	Lysine (K)-specific demethylase 6B, b. (1729 aa)
	nodal	Nodal-related 2. (376 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	LOC103477083	Ventral homeobox. (243 aa)
	exoc4	Exocyst complex component 4. (994 aa)
	hmga2	Uncharacterized protein. (115 aa)
	LOC103457498	Mesogenin 1. (144 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103474014	Ephrin-A5a; Belongs to the ephrin family. (229 aa)
	SRF	Serum response factor. (243 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103470513	Metalloendopeptidase. (970 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (376 aa)
	gpi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (580 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	srf	Serum response factor b. (570 aa)
	LOC103462739	Mesoderm posterior aa. (232 aa)
	nf2	Neurofibromin 2b (merlin). (615 aa)
	LOC103475798	Lysine (K)-specific demethylase 6A, like. (1466 aa)
	armc5	Armadillo repeat containing 5. (841 aa)
	pofut2	Protein O-fucosyltransferase 2. (403 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
	LOC103469022	Uncharacterized protein; Belongs to the integrin alpha chain family. (900 aa)
	LOC103460961	Integrin beta. (357 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	vsx1	Uncharacterized protein. (275 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (212 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	LOC103482434	Forkhead box H1. (633 aa)
	LOC103471993	T-box transcription factor Ta. (421 aa)
	kdm6b	Lysine (K)-specific demethylase 6B, a. (2105 aa)
	LOC103461155	Neurofibromin 2a (merlin). (394 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (224 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	LOC103466381	Glucose-6-phosphate isomerase; Belongs to the GPI family. (547 aa)
	taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (186 aa)
	LOC103461763	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (871 aa)
	LOC103479412	T-cell acute lymphocytic leukemia 1. (394 aa)
	itgb4	Integrin, beta 4. (1248 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103481979	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1089 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1447 aa)
	ENSPREP00000030719	Uncharacterized protein. (708 aa)
	LOC103470287	Southpaw. (408 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (671 aa)
	tbxt	T-box transcription factor Tb. (436 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000030719	LOC103475798	ENSPREP00000030719	ENSPREP00000014271	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.751
ENSPREP00000030719	LOC103475867	ENSPREP00000030719	ENSPREP00000002425	Uncharacterized protein.	Lysine (K)-specific demethylase 6B, b.	0.701
ENSPREP00000030719	kdm6a	ENSPREP00000030719	ENSPREP00000030520	Uncharacterized protein.	Lysine (K)-specific demethylase 6A.	0.751
ENSPREP00000030719	kdm6b	ENSPREP00000030719	ENSPREP00000021959	Uncharacterized protein.	Lysine (K)-specific demethylase 6B, a.	0.701
LOC103457498	LOC103471993	ENSPREP00000006894	ENSPREP00000021918	Mesogenin 1.	T-box transcription factor Ta.	0.456
LOC103457498	tbxt	ENSPREP00000006894	ENSPREP00000034173	Mesogenin 1.	T-box transcription factor Tb.	0.455
LOC103460961	LOC103469022	ENSPREP00000018238	ENSPREP00000018069	Integrin beta.	Uncharacterized protein; Belongs to the integrin alpha chain family.	0.801
LOC103460961	LOC103481979	ENSPREP00000018238	ENSPREP00000029873	Integrin beta.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.801
LOC103460961	itgb4	ENSPREP00000018238	ENSPREP00000027905	Integrin beta.	Integrin, beta 4.	0.947
LOC103461155	nf2	ENSPREP00000023162	ENSPREP00000014172	Neurofibromin 2a (merlin).	Neurofibromin 2b (merlin).	0.901
LOC103461763	bmp2	ENSPREP00000025817	ENSPREP00000023949	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 2b.	0.718
LOC103466381	gpi	ENSPREP00000024990	ENSPREP00000010994	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.901
LOC103469022	LOC103460961	ENSPREP00000018069	ENSPREP00000018238	Uncharacterized protein; Belongs to the integrin alpha chain family.	Integrin beta.	0.801
LOC103469022	itgb4	ENSPREP00000018069	ENSPREP00000027905	Uncharacterized protein; Belongs to the integrin alpha chain family.	Integrin, beta 4.	0.801
LOC103470287	LOC103482434	ENSPREP00000032036	ENSPREP00000021830	Southpaw.	Forkhead box H1.	0.432
LOC103470287	nodal	ENSPREP00000032036	ENSPREP00000002870	Southpaw.	Nodal-related 2.	0.900
LOC103470891	LOC103474475	ENSPREP00000030084	ENSPREP00000028750	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.792
LOC103470891	sfrp2	ENSPREP00000030084	ENSPREP00000000067	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.792
LOC103470891	wnt3	ENSPREP00000030084	ENSPREP00000017531	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.450
LOC103470891	wnt3a	ENSPREP00000030084	ENSPREP00000011284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.453