(44 nodes) Neuron fate commitment network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	LOC103456513	Uncharacterized protein. (883 aa)
	lbx1	Homeobox domain-containing protein. (273 aa)
	ENSPREP00000001881	T-box transcription factor 2a. (572 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	foxg1	Forkhead box G1a. (346 aa)
	LOC103458650	Oligodendrocyte transcription factor 4. (256 aa)
	olig2	Oligodendrocyte lineage transcription factor 2. (273 aa)
	ENSPREP00000005434	BHLH domain-containing protein. (212 aa)
	LOC103474746	Fork-head domain-containing protein. (389 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC103471118	BHLH domain-containing protein. (243 aa)
	LOC103466630	Peptidylprolyl isomerase. (467 aa)
	gbx1	Gastrulation brain homeobox 1. (322 aa)
	axin1	Axin 1. (850 aa)
	isl2	ISL LIM homeobox 2a. (359 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (320 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	olig3	Oligodendrocyte transcription factor 3. (220 aa)
	fkbp8	Peptidylprolyl isomerase. (396 aa)
	LOC103477376	Forkhead box G1d. (344 aa)
	lhx9	LIM homeobox 9. (505 aa)
	lhx2	LIM homeobox 2b. (363 aa)
	ENSPREP00000020228	Thyroid hormone receptor beta. (482 aa)
	LOC103478252	Growth differentiation factor 6a. (418 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	LOC103460561	Homeobox domain-containing protein. (316 aa)
	ENSPREP00000023031	Atonal bHLH transcription factor 1c. (150 aa)
	LHX3	LIM homeobox 3. (409 aa)
	LOC103469637	ISL LIM homeobox 1. (373 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (994 aa)
	lhx4	LIM homeobox 4. (389 aa)
	atoh1	Atonal bHLH transcription factor 1a. (357 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	gsx2	GS homeobox 2. (239 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103467376	Homeobox C10a. (340 aa)
	gsx1	GS homeobox 1. (243 aa)
	zdhhc16	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (384 aa)
	zc4h2	Zinc finger, C4H2 domain containing. (224 aa)
	gdf5	Growth differentiation factor 5. (484 aa)
	ENSPREP00000032096	LIM zinc-binding domain-containing protein. (71 aa)
	foxn4	Forkhead box N4. (500 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005434	atoh1	ENSPREP00000005434	ENSPREP00000027018	BHLH domain-containing protein.	Atonal bHLH transcription factor 1a.	0.404
LHX3	LOC103469637	ENSPREP00000024464	ENSPREP00000025299	LIM homeobox 3.	ISL LIM homeobox 1.	0.840
LHX3	isl2	ENSPREP00000024464	ENSPREP00000012219	LIM homeobox 3.	ISL LIM homeobox 2a.	0.840
LOC103456513	axin1	ENSPREP00000000160	ENSPREP00000012177	Uncharacterized protein.	Axin 1.	0.902
LOC103469637	LHX3	ENSPREP00000025299	ENSPREP00000024464	ISL LIM homeobox 1.	LIM homeobox 3.	0.840
LOC103469637	lhx4	ENSPREP00000025299	ENSPREP00000026499	ISL LIM homeobox 1.	LIM homeobox 4.	0.840
LOC103473773	LOC103474746	ENSPREP00000020499	ENSPREP00000006009	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.449
LOC103473773	LOC103477376	ENSPREP00000020499	ENSPREP00000017773	Mothers against decapentaplegic homolog.	Forkhead box G1d.	0.449
LOC103473773	LOC103477474	ENSPREP00000020499	ENSPREP00000022544	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103473773	foxg1	ENSPREP00000020499	ENSPREP00000004343	Mothers against decapentaplegic homolog.	Forkhead box G1a.	0.449
LOC103474746	LOC103473773	ENSPREP00000006009	ENSPREP00000020499	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.449
LOC103474746	LOC103477474	ENSPREP00000006009	ENSPREP00000022544	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.449
LOC103474746	SMAD4	ENSPREP00000006009	ENSPREP00000027467	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.449
LOC103476521	dlx3	ENSPREP00000029747	ENSPREP00000006756	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.404
LOC103476521	fgf3	ENSPREP00000029747	ENSPREP00000002583	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.795
LOC103476521	shh	ENSPREP00000029747	ENSPREP00000013208	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.554
LOC103477376	LOC103473773	ENSPREP00000017773	ENSPREP00000020499	Forkhead box G1d.	Mothers against decapentaplegic homolog.	0.449
LOC103477376	LOC103477474	ENSPREP00000017773	ENSPREP00000022544	Forkhead box G1d.	Mothers against decapentaplegic homolog.	0.449
LOC103477376	SMAD4	ENSPREP00000017773	ENSPREP00000027467	Forkhead box G1d.	Mothers against decapentaplegic homolog.	0.449
LOC103477376	fgf3	ENSPREP00000017773	ENSPREP00000002583	Forkhead box G1d.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.487