(27 nodes) Embryonic viscerocranium morphogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103467726	RAD21 cohesin complex component like 1. (539 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC103472890	RAD21 cohesin complex component b. (644 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	dlx2	Distal-less homeobox 2b. (278 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	tbx10	Uncharacterized protein. (280 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	fst	Follistatin a. (351 aa)
	pitx2	Homeobox protein. (312 aa)
	alcam	Activated leukocyte cell adhesion molecule b. (559 aa)
	nbas	Neuroblastoma amplified sequence. (2365 aa)
	LOC103478347	RAD21 cohesin complex component a. (637 aa)
	med12	Mediator complex subunit 12. (2052 aa)
	ENSPREP00000020767	Uncharacterized protein. (110 aa)
	LOC103473783	Nipped-B protein. (2642 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	tbx1	T-box transcription factor 1. (498 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	nipbl	Nipped-B protein. (2355 aa)
	LOC103470947	RNA polymerase I and III subunit D. (114 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	gnptab	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1210 aa)
	dlx1	Distal-less homeobox 1a. (252 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	mmachc	Metabolism of cobalamin associated C. (274 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000020767	LOC103467726	ENSPREP00000020767	ENSPREP00000003268	Uncharacterized protein.	RAD21 cohesin complex component like 1.	0.819
ENSPREP00000020767	LOC103472890	ENSPREP00000020767	ENSPREP00000002991	Uncharacterized protein.	RAD21 cohesin complex component b.	0.819
ENSPREP00000020767	LOC103473783	ENSPREP00000020767	ENSPREP00000020900	Uncharacterized protein.	Nipped-B protein.	0.899
ENSPREP00000020767	LOC103478347	ENSPREP00000020767	ENSPREP00000018269	Uncharacterized protein.	RAD21 cohesin complex component a.	0.819
LOC103459284	LOC103467447	ENSPREP00000006858	ENSPREP00000028159	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103459284	wnt4	ENSPREP00000006858	ENSPREP00000026620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.613
LOC103467447	LOC103459284	ENSPREP00000028159	ENSPREP00000006858	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103467447	wnt4	ENSPREP00000028159	ENSPREP00000026620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
LOC103467726	ENSPREP00000020767	ENSPREP00000003268	ENSPREP00000020767	RAD21 cohesin complex component like 1.	Uncharacterized protein.	0.819
LOC103467726	LOC103472890	ENSPREP00000003268	ENSPREP00000002991	RAD21 cohesin complex component like 1.	RAD21 cohesin complex component b.	0.904
LOC103467726	LOC103473783	ENSPREP00000003268	ENSPREP00000020900	RAD21 cohesin complex component like 1.	Nipped-B protein.	0.819
LOC103467726	LOC103478347	ENSPREP00000003268	ENSPREP00000018269	RAD21 cohesin complex component like 1.	RAD21 cohesin complex component a.	0.904
LOC103467726	nipbl	ENSPREP00000003268	ENSPREP00000028828	RAD21 cohesin complex component like 1.	Nipped-B protein.	0.819
LOC103472890	ENSPREP00000020767	ENSPREP00000002991	ENSPREP00000020767	RAD21 cohesin complex component b.	Uncharacterized protein.	0.819
LOC103472890	LOC103467726	ENSPREP00000002991	ENSPREP00000003268	RAD21 cohesin complex component b.	RAD21 cohesin complex component like 1.	0.904
LOC103472890	LOC103473783	ENSPREP00000002991	ENSPREP00000020900	RAD21 cohesin complex component b.	Nipped-B protein.	0.819
LOC103472890	LOC103478347	ENSPREP00000002991	ENSPREP00000018269	RAD21 cohesin complex component b.	RAD21 cohesin complex component a.	0.901
LOC103472890	nipbl	ENSPREP00000002991	ENSPREP00000028828	RAD21 cohesin complex component b.	Nipped-B protein.	0.819
LOC103473783	ENSPREP00000020767	ENSPREP00000020900	ENSPREP00000020767	Nipped-B protein.	Uncharacterized protein.	0.899
LOC103473783	LOC103467726	ENSPREP00000020900	ENSPREP00000003268	Nipped-B protein.	RAD21 cohesin complex component like 1.	0.819