(71 nodes) Presynaptic active zone network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000000902	Netrin G2. (211 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	LOC103468036	Aa_trans domain-containing protein. (512 aa)
	stx1a	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (368 aa)
	LOC103469661	Syntaxin 2b; Belongs to the syntaxin family. (293 aa)
	PPFIBP2	Uncharacterized protein. (1018 aa)
	pclo	Piccolo presynaptic cytomatrix protein a. (3491 aa)
	LOC103469794	Uncharacterized protein. (1517 aa)
	ppfia4	PTPRF interacting protein alpha 4. (1135 aa)
	STX11	Syntaxin 11. (295 aa)
	LOC103457516	t-SNARE coiled-coil homology domain-containing protein. (296 aa)
	LOC103471241	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
	LOC103459282	ELKS/RAB6-interacting/CAST family member 1. (1157 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103462684	Neuroplastin b. (379 aa)
	LOC103457483	Otoferlin a. (1904 aa)
	Unc13b	Uncharacterized protein. (3189 aa)
	UNC13C	Unc-13 homolog C. (2664 aa)
	ENSPREP00000008454	C2 domain-containing protein. (216 aa)
	LOC103481571	Uncharacterized protein. (1016 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	cplx3	Complexin 3b. (156 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	ENSPREP00000012437	Uncharacterized protein. (179 aa)
	erc2	ELKS/RAB6-interacting/CAST family member 2. (1137 aa)
	unc13a	Uncharacterized protein. (1552 aa)
	ENSPREP00000012584	Bassoon (presynaptic cytomatrix protein) b. (3254 aa)
	slc32a1	Solute carrier family 32 member 1. (526 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	rims1	Regulating synaptic membrane exocytosis 1a. (1422 aa)
	ENSPREP00000014713	Aa_trans domain-containing protein. (420 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	ntng1	Netrin g1a. (527 aa)
	ctbp1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (423 aa)
	LOC103468986	PTPRF interacting protein alpha 3. (1258 aa)
	LOC103479750	Vav 3 guanine nucleotide exchange factor b. (457 aa)
	LOC103476756	Uncharacterized protein. (1177 aa)
	stx1b	Syntaxin 1B; Belongs to the syntaxin family. (312 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	STX19	Syntaxin 19. (303 aa)
	LOC103462868	PPFIA binding protein 2a. (970 aa)
	LOC103481737	Syntaxin 4; Belongs to the syntaxin family. (294 aa)
	bsn	Uncharacterized protein. (4180 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (928 aa)
	ENSPREP00000020827	Uncharacterized protein. (1109 aa)
	NTNG2	Netrin G2. (224 aa)
	nufip1	C2H2-type domain-containing protein. (533 aa)
	ENSPREP00000021283	t-SNARE coiled-coil homology domain-containing protein. (318 aa)
	otof	Otoferlin b. (1641 aa)
	LOC103472577	Uncharacterized protein. (1105 aa)
	pnisr	Uncharacterized protein. (832 aa)
	LOC103466432	Si:ch73-330k17.3. (167 aa)
	LOC103463013	PTPRF interacting protein alpha 1. (1183 aa)
	stx11	Syntaxin 11a; Belongs to the syntaxin family. (288 aa)
	LOC103466425	Uncharacterized protein. (380 aa)
	erc1	ELKS/RAB6-interacting/CAST family member 1a. (1115 aa)
	nectin1	Nectin cell adhesion molecule 1b. (508 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1303 aa)
	NTNG2-2	Netrin g2a. (1094 aa)
	LOC103457071	Fer-1 like family member 6. (1480 aa)
	stx3	Syntaxin 3A; Belongs to the syntaxin family. (323 aa)
	ppfibp1	PPFIA binding protein 1b. (993 aa)
	LOC103479452	Unc-13 homolog A. (1870 aa)
	ERC2	Uncharacterized protein. (669 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	LOC103474519	Zgc:172282. (693 aa)
	LOC103472178	Regulating synaptic membrane exocytosis 3. (323 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1119 aa)
	LOC103470421	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (285 aa)
	ppfia2	PTPRF interacting protein alpha 2. (1185 aa)
	LOC103459137	PPFIA binding protein 1a. (879 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000000902	NTNG2	ENSPREP00000000902	ENSPREP00000020885	Netrin G2.	Netrin G2.	0.920
ENSPREP00000000902	NTNG2-2	ENSPREP00000000902	ENSPREP00000024154	Netrin G2.	Netrin g2a.	0.900
ENSPREP00000008454	ENSPREP00000021283	ENSPREP00000008454	ENSPREP00000021283	C2 domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.425
ENSPREP00000008454	LOC103457516	ENSPREP00000008454	ENSPREP00000005732	C2 domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.425
ENSPREP00000008454	LOC103463013	ENSPREP00000008454	ENSPREP00000023365	C2 domain-containing protein.	PTPRF interacting protein alpha 1.	0.489
ENSPREP00000008454	LOC103468986	ENSPREP00000008454	ENSPREP00000016524	C2 domain-containing protein.	PTPRF interacting protein alpha 3.	0.489
ENSPREP00000008454	LOC103469661	ENSPREP00000008454	ENSPREP00000002499	C2 domain-containing protein.	Syntaxin 2b; Belongs to the syntaxin family.	0.501
ENSPREP00000008454	LOC103470421	ENSPREP00000008454	ENSPREP00000032381	C2 domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.501
ENSPREP00000008454	LOC103472178	ENSPREP00000008454	ENSPREP00000031671	C2 domain-containing protein.	Regulating synaptic membrane exocytosis 3.	0.636
ENSPREP00000008454	LOC103472577	ENSPREP00000008454	ENSPREP00000023069	C2 domain-containing protein.	Uncharacterized protein.	0.996
ENSPREP00000008454	LOC103481737	ENSPREP00000008454	ENSPREP00000019745	C2 domain-containing protein.	Syntaxin 4; Belongs to the syntaxin family.	0.500
ENSPREP00000008454	PPFIA3	ENSPREP00000008454	ENSPREP00000031982	C2 domain-containing protein.	PTPRF interacting protein alpha 3.	0.489
ENSPREP00000008454	RIMS2	ENSPREP00000008454	ENSPREP00000023895	C2 domain-containing protein.	Regulating synaptic membrane exocytosis 2.	0.996
ENSPREP00000008454	STX11	ENSPREP00000008454	ENSPREP00000005703	C2 domain-containing protein.	Syntaxin 11.	0.425
ENSPREP00000008454	UNC13C	ENSPREP00000008454	ENSPREP00000008426	C2 domain-containing protein.	Unc-13 homolog C.	0.898
ENSPREP00000008454	Unc13b	ENSPREP00000008454	ENSPREP00000008315	C2 domain-containing protein.	Uncharacterized protein.	0.894
ENSPREP00000008454	ppfia2	ENSPREP00000008454	ENSPREP00000033089	C2 domain-containing protein.	PTPRF interacting protein alpha 2.	0.489
ENSPREP00000008454	ppfia4	ENSPREP00000008454	ENSPREP00000004946	C2 domain-containing protein.	PTPRF interacting protein alpha 4.	0.489
ENSPREP00000008454	rims1	ENSPREP00000008454	ENSPREP00000014499	C2 domain-containing protein.	Regulating synaptic membrane exocytosis 1a.	0.636
ENSPREP00000008454	stx11	ENSPREP00000008454	ENSPREP00000023439	C2 domain-containing protein.	Syntaxin 11a; Belongs to the syntaxin family.	0.425