(22 nodes) Otolith development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103458474	Otolith matrix protein. (372 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	mdn1	Midasin AAA ATPase 1. (3952 aa)
	ENSPREP00000001981	Uncharacterized protein. (359 aa)
	ENSPREP00000002466	GAS domain-containing protein. (320 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	slc44a4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (718 aa)
	LOC103472134	GAS domain-containing protein. (511 aa)
	LOC103479575	Tetratricopeptide repeat domain 39C. (666 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	LOC103480354	Vang-like protein. (525 aa)
	ttc25	Tetratricopeptide repeat domain 25. (464 aa)
	atg4b	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (391 aa)
	TTC39C	Tetratricopeptide repeat domain 39C. (507 aa)
	ttc36	Tetratricopeptide repeat domain 36. (187 aa)
	bloc1s5	Biogenesis of lysosomal organelles complex-1, subunit 5, muted. (153 aa)
	LOC103479413	Otolin 1a. (493 aa)
	b4galt5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5. (352 aa)
	lrig1	Leucine-rich repeats and immunoglobulin-like domains 1. (1055 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001981	mdn1	ENSPREP00000001981	ENSPREP00000001868	Uncharacterized protein.	Midasin AAA ATPase 1.	0.947
LOC103458474	LOC103479413	ENSPREP00000014568	ENSPREP00000025967	Otolith matrix protein.	Otolin 1a.	0.531
LOC103459284	LOC103467447	ENSPREP00000006858	ENSPREP00000028159	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103459284	LOC103480354	ENSPREP00000006858	ENSPREP00000012627	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Vang-like protein.	0.437
LOC103459284	VANGL2	ENSPREP00000006858	ENSPREP00000001301	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	VANGL planar cell polarity protein 2.	0.437
LOC103467447	LOC103459284	ENSPREP00000028159	ENSPREP00000006858	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103467447	LOC103480354	ENSPREP00000028159	ENSPREP00000012627	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Vang-like protein.	0.437
LOC103467447	VANGL2	ENSPREP00000028159	ENSPREP00000001301	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	VANGL planar cell polarity protein 2.	0.437
LOC103479413	LOC103458474	ENSPREP00000025967	ENSPREP00000014568	Otolin 1a.	Otolith matrix protein.	0.531
LOC103480354	LOC103459284	ENSPREP00000012627	ENSPREP00000006858	Vang-like protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
LOC103480354	LOC103467447	ENSPREP00000012627	ENSPREP00000028159	Vang-like protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
VANGL2	LOC103459284	ENSPREP00000001301	ENSPREP00000006858	VANGL planar cell polarity protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
VANGL2	LOC103467447	ENSPREP00000001301	ENSPREP00000028159	VANGL planar cell polarity protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
atg4b	atg5	ENSPREP00000021604	ENSPREP00000028618	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.683
atg5	atg4b	ENSPREP00000028618	ENSPREP00000021604	Autophagy protein 5; Involved in autophagic vesicle formation.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.683
mdn1	ENSPREP00000001981	ENSPREP00000001868	ENSPREP00000001981	Midasin AAA ATPase 1.	Uncharacterized protein.	0.947