(151 nodes) Regulation of epithelial cell proliferation network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479394	Secretogranin II (chromogranin C), b. (585 aa)
	ecm1	Uncharacterized protein. (482 aa)
	stxbp4	Syntaxin binding protein 4. (705 aa)
	pex2	Peroxisomal biogenesis factor 2. (335 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	Vegfb	Vascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (94 aa)
	LOC103470111	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	LOC103480960	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1b. (337 aa)
	LOC103476302	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	Prok1	Prokineticin 1. (100 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	Pgf	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (152 aa)
	tbc1d31	TBC1 domain family, member 31. (1060 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	LOC103461010	Uncharacterized protein. (283 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (427 aa)
	ENSPREP00000020034	JunE proto-oncogene, AP-1 transcription factor subunit. (310 aa)
	LOC103461059	LIM and senescent cell antigen-like domains 2. (438 aa)
	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (121 aa)
	LOC103463292	Usher syndrome 1C binding protein 1. (792 aa)
	ENSPREP00000018488	EMI domain-containing protein. (599 aa)
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	tnmd	Tenomodulin. (296 aa)
	LOC103465931	Cyclin-dependent kinase inhibitor 1Cb. (217 aa)
	GATA2	GATA binding protein 2. (462 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC103476207	Si:dkey-175m17.7. (913 aa)
	ift74	Intraflagellar transport 74. (602 aa)
	LOC103479234	Uncharacterized protein. (291 aa)
	LOC103465909	Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
	LOC103468998	Uncharacterized protein. (812 aa)
	LOC103473699	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	epcam	Epithelial cell adhesion molecule. (309 aa)
	scg2	Uncharacterized protein. (622 aa)
	LOC103470605	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	rreb1	Ras responsive element binding protein 1a. (1526 aa)
	ngfr	Nerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
	LOC103459498	Cyclin-dependent kinase inhibitor 1D. (179 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	LOC103469984	EGF-like domain-containing protein. (176 aa)
	LOC103475843	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (950 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	WDR77	WD repeat domain 77. (347 aa)
	kdf1	Keratinocyte differentiation factor 1a. (362 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	Grn	Uncharacterized protein. (68 aa)
	ENSPREP00000012772	GRANULINS domain-containing protein. (152 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (799 aa)
	LOC103462620	Uncharacterized protein. (254 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	flcn	Folliculin. (554 aa)
	sp1	Sp1 transcription factor. (593 aa)
	LOC103471859	Fibroblast growth factor binding protein 1b. (202 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	ENSPREP00000009700	Uncharacterized protein. (280 aa)
	ENSPREP00000009672	Uncharacterized protein. (343 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (466 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103470500	NK3 homeobox 1. (196 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (126 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (430 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (576 aa)
	f3	Coagulation factor IIIa. (285 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	ENSPREP00000007878	Sulfatase domain-containing protein. (248 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC103475985	TERF1 (TRF1)-interacting nuclear factor 2. (560 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	xbp1	X-box binding protein 1. (385 aa)
	LOC103465183	Cyclin-dependent kinase inhibitor 1A. (156 aa)
	C5AR1	Complement C5a receptor 1. (350 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	il10	Interleukin 10. (229 aa)
	eaf2	ELL associated factor 2. (255 aa)
	st8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (349 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1350 aa)
	LOC103472251	Uncharacterized protein. (260 aa)
	wdr13	WD repeat domain 13. (393 aa)
	sirt1	Sirtuin 1. (677 aa)
	Cav1	Uncharacterized protein. (84 aa)
	aimp1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1a. (317 aa)
	Tgfa	Transforming growth factor, alpha. (166 aa)
	deaf1	DEAF1 transcription factor. (468 aa)
	atp5f1a	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
	vip	Vasoactive intestinal peptide. (184 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (778 aa)
	LOC103459045	Chondromodulin. (331 aa)
	ENSPREP00000002835	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (282 aa)
	LOC103479190	Chondromodulin. (267 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (1006 aa)
	fa2h	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (381 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (751 aa)
	APOH-2	Apolipoprotein H. (363 aa)
	APOH	Uncharacterized protein. (348 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	ENSPREP00000000130	Uncharacterized protein. (54 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103461979	LIM and senescent cell antigen-like domains 2. (203 aa)
	ENSPREP00000031580	LIM zinc-binding domain-containing protein. (57 aa)
	agtr1	Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	hmgn5	High mobility group nucleosome binding domain 6. (81 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	sulf2	Sulfatase 2a. (819 aa)
	LOC103465574	Inhibitor of DNA binding 1, HLH protein. (127 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)
	LOC103481795	Nerve growth factor receptor b. (354 aa)
	LOC103470093	Homeobox domain-containing protein. (363 aa)
	ar	Androgen receptor. (685 aa)
	LOC103475709	Androgen receptor. (757 aa)
	cask	Uncharacterized protein; Belongs to the MAGUK family. (884 aa)
	Rgcc	Regulator of cell cycle. (134 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC103467401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	LOC103481969	Baculoviral IAP repeat containing 5a. (157 aa)
	ENSPREP00000029470	Uncharacterized protein. (1405 aa)
	LOC103472707	Pygopus homolog 2 (Drosophila). (588 aa)
	nkx2-3	NK2 homeobox 3. (349 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103473319	C2H2-type domain-containing protein. (515 aa)
	VASH1	Vasohibin 1. (332 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	vash2	Vasohibin 2. (367 aa)
	sulf1	Sulfatase 1. (1148 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	LOC103460470	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (496 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	LOC103465060	GATA binding protein 2a. (456 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (404 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	sav1	Salvador family WW domain containing protein 1. (383 aa)
	mydgf	Myeloid-derived growth factor. (160 aa)
	LOC103461763	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (871 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
Adam17	LOC103481795	ENSPREP00000021960	ENSPREP00000033927	Pep_M12B_propep domain-containing protein.	Nerve growth factor receptor b.	0.504
Adam17	Tgfa	ENSPREP00000021960	ENSPREP00000003483	Pep_M12B_propep domain-containing protein.	Transforming growth factor, alpha.	0.463
Adam17	ngfr	ENSPREP00000021960	ENSPREP00000014410	Pep_M12B_propep domain-containing protein.	Nerve growth factor receptor a (TNFR superfamily, member 16).	0.504
BAX	bad	ENSPREP00000013021	ENSPREP00000030076	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death b.	0.739
C5AR1	agtr1	ENSPREP00000006094	ENSPREP00000032143	Complement C5a receptor 1.	Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family.	0.481
Cav1	LOC103477848	ENSPREP00000003891	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.418
ENSPREP00000000130	LOC103470605	ENSPREP00000000130	ENSPREP00000015501	Uncharacterized protein.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.871
ENSPREP00000000130	LOC103473699	ENSPREP00000000130	ENSPREP00000016071	Uncharacterized protein.	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	0.870
ENSPREP00000002835	GATA2	ENSPREP00000002835	ENSPREP00000018023	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	GATA binding protein 2.	0.460
ENSPREP00000002835	LOC103465060	ENSPREP00000002835	ENSPREP00000026296	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	GATA binding protein 2a.	0.460
ENSPREP00000002835	LOC103475985	ENSPREP00000002835	ENSPREP00000006753	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	TERF1 (TRF1)-interacting nuclear factor 2.	0.414
ENSPREP00000002835	sirt1	ENSPREP00000002835	ENSPREP00000003960	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Sirtuin 1.	0.628
ENSPREP00000002835	sp1	ENSPREP00000002835	ENSPREP00000011446	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Sp1 transcription factor.	0.683
ENSPREP00000006768	LOC103471859	ENSPREP00000006768	ENSPREP00000010541	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor binding protein 1b.	0.730
ENSPREP00000006768	LOC103475119	ENSPREP00000006768	ENSPREP00000027136	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.409
ENSPREP00000006768	fgf7	ENSPREP00000006768	ENSPREP00000012669	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
ENSPREP00000006768	igf1	ENSPREP00000006768	ENSPREP00000010429	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Insulin-like growth factor 1.	0.431
ENSPREP00000006768	mydgf	ENSPREP00000006768	ENSPREP00000025924	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Myeloid-derived growth factor.	0.681