(92 nodes) Positive regulation of peptidyl-tyrosine phosphorylation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	unc119	Unc-119 lipid binding chaperone. (219 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Bb. (419 aa)
	ENSPREP00000000845	Uncharacterized protein. (161 aa)
	arl2bp	ADP-ribosylation factor-like 2 binding protein. (179 aa)
	ABI1	Abl-interactor 1a. (577 aa)
	ENSPREP00000002283	Uncharacterized protein. (66 aa)
	ENSPREP00000002463	Uncharacterized protein. (305 aa)
	ENSPREP00000002720	Uncharacterized protein. (221 aa)
	lrrk1	Uncharacterized protein. (2016 aa)
	Tgfa	Transforming growth factor, alpha. (166 aa)
	ENSPREP00000003699	SH3 domain-containing protein. (137 aa)
	ENSPREP00000003717	Uncharacterized protein. (76 aa)
	LOC103473479	EGF-like domain-containing protein. (217 aa)
	ENSPREP00000004666	Si:dkey-237i9.8. (616 aa)
	LOC103464868	Interleukin 19 like. (200 aa)
	nrg2	Neuregulin 2b. (712 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1057 aa)
	LOC103474759	Somatolactin alpha. (231 aa)
	LOC103473556	Uncharacterized protein. (2297 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	LOC103474014	Ephrin-A5a; Belongs to the ephrin family. (229 aa)
	LOC103470484	GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (481 aa)
	LOC103471128	Heparin-binding EGF-like growth factor a. (236 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (903 aa)
	LOC103476623	Uncharacterized protein. (392 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	LOC103469200	G protein-coupled receptor, class C, group 5, member Ba. (397 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	LOC103475650	Vitronectin b. (444 aa)
	vtn	Vitronectin a. (568 aa)
	LOC103475648	Unc-119 lipid binding chaperone. (250 aa)
	LOC103478037	Interleukin 11a. (200 aa)
	LOC103463628	Cytokine receptor-like factor 1b. (402 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	LOC103469984	EGF-like domain-containing protein. (176 aa)
	LOC103469991	Si:dkey-193c22.2. (2420 aa)
	crlf1	Cytokine receptor-like factor 1a. (400 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1760 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (333 aa)
	DGKQ	Diacylglycerol kinase. (895 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	LOC103458433	Non-specific serine/threonine protein kinase. (507 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (765 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (452 aa)
	LOC103456982	SH2 domain-containing protein. (202 aa)
	LOC103460214	Uncharacterized protein. (269 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	il6st	Uncharacterized protein. (896 aa)
	LOC103473128	EGF-like domain-containing protein. (621 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1230 aa)
	cspg4	Chondroitin sulfate proteoglycan 4. (2287 aa)
	DOK7	Docking protein 7. (515 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (304 aa)
	ENSPREP00000022997	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (200 aa)
	LOC103469131	Platelet/endothelial cell adhesion molecule 1. (797 aa)
	LOC103464180	Uncharacterized protein. (116 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (894 aa)
	IL18	Uncharacterized protein. (218 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (224 aa)
	RELN	Reelin. (3446 aa)
	LOC103478148	Interleukin 6 receptor. (603 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	LOC103471376	Uncharacterized protein. (383 aa)
	LOC103478167	Ephrin-A1b; Belongs to the ephrin family. (232 aa)
	ncf1	Neutrophil cytosolic factor 1. (438 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	LOC103475452	Neuregulin 2a. (731 aa)
	ENSPREP00000028311	Uncharacterized protein. (97 aa)
	LOC103472698	Ephrin-A1a; Belongs to the ephrin family. (221 aa)
	nox4	FAD-binding FR-type domain-containing protein. (540 aa)
	il34	Interleukin 34. (223 aa)
	ENSPREP00000029402	DBB domain-containing protein. (577 aa)
	hax1	HCLS1 associated protein X-1. (288 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	GREM1	Gremlin. (182 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	LOC103465552	GATA binding protein 1a. (426 aa)
	ENSPREP00000030675	Cas scaffold protein family member 4. (795 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	tnfrsf18	CD40 molecule, TNF receptor superfamily member 5. (314 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (496 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	gas6	Uncharacterized protein. (650 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	LOC103458433	ENSPREP00000001513	ENSPREP00000016553	Abl-interactor 1a.	Non-specific serine/threonine protein kinase.	0.401
ABI1	pak2	ENSPREP00000001513	ENSPREP00000030798	Abl-interactor 1a.	Non-specific serine/threonine protein kinase.	0.401
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
Adam17	Tgfa	ENSPREP00000021960	ENSPREP00000003483	Pep_M12B_propep domain-containing protein.	Transforming growth factor, alpha.	0.463
ENSPREP00000000845	IL18	ENSPREP00000000845	ENSPREP00000023832	Uncharacterized protein.	Uncharacterized protein.	0.400
ENSPREP00000002720	igf1	ENSPREP00000002720	ENSPREP00000010429	Uncharacterized protein.	Insulin-like growth factor 1.	0.643
ENSPREP00000002720	ptprc	ENSPREP00000002720	ENSPREP00000018309	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.471
ENSPREP00000003699	LOC103458433	ENSPREP00000003699	ENSPREP00000016553	SH3 domain-containing protein.	Non-specific serine/threonine protein kinase.	0.401
ENSPREP00000003699	pak2	ENSPREP00000003699	ENSPREP00000030798	SH3 domain-containing protein.	Non-specific serine/threonine protein kinase.	0.401
ENSPREP00000003717	LOC103458433	ENSPREP00000003717	ENSPREP00000016553	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.401
ENSPREP00000003717	pak2	ENSPREP00000003717	ENSPREP00000030798	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.401
ENSPREP00000004666	ptprc	ENSPREP00000004666	ENSPREP00000018309	Si:dkey-237i9.8.	Protein tyrosine phosphatase receptor type C.	0.504
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000016378	rictor	ENSPREP00000016378	ENSPREP00000015091	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	RPTOR independent companion of MTOR, complex 2 a.	0.971
ENSPREP00000021987	Adam17	ENSPREP00000021987	ENSPREP00000021960	ADAM metallopeptidase domain 17b.	Pep_M12B_propep domain-containing protein.	0.932
ENSPREP00000021987	Tgfa	ENSPREP00000021987	ENSPREP00000003483	ADAM metallopeptidase domain 17b.	Transforming growth factor, alpha.	0.463
ENSPREP00000030326	LOC103461485	ENSPREP00000030326	ENSPREP00000010220	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.902
IL18	ENSPREP00000000845	ENSPREP00000023832	ENSPREP00000000845	Uncharacterized protein.	Uncharacterized protein.	0.400
LOC103458433	ABI1	ENSPREP00000016553	ENSPREP00000001513	Non-specific serine/threonine protein kinase.	Abl-interactor 1a.	0.401