(77 nodes) Positive regulation of synaptic transmission network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103472178	Regulating synaptic membrane exocytosis 3. (323 aa)
	LOC103470421	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (285 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	NRGN	Neurogranin. (90 aa)
	lgi1	Leucine-rich, glioma inactivated 1b. (576 aa)
	ca7	Carbonic anhydrase VII; Belongs to the alpha-carbonic anhydrase family. (262 aa)
	LOC103462623	Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b. (1385 aa)
	LOC103479134	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (317 aa)
	cacng5	Calcium channel, voltage-dependent, gamma subunit 5a. (291 aa)
	cacng4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
	LOC103467909	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (615 aa)
	LOC103472856	Shisa family member 7. (679 aa)
	LOC103472853	Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1973 aa)
	ENSPREP00000001193	Calcium voltage-gated channel auxiliary subunit gamma 7. (251 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	ENSPREP00000001630	RHD domain-containing protein. (238 aa)
	Nfatc4	Uncharacterized protein. (238 aa)
	stx1a	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (368 aa)
	LOC103469661	Syntaxin 2b; Belongs to the syntaxin family. (293 aa)
	prrt1	Proline-rich transmembrane protein 1. (250 aa)
	tshz3	Teashirt zinc finger homeobox 3b. (1068 aa)
	fmr1	Fragile X mental retardation 1. (273 aa)
	zdhhc12	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (273 aa)
	LOC103469267	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (320 aa)
	LOC103462684	Neuroplastin b. (379 aa)
	LOC103479055	Sodium leak channel, non-selective. (548 aa)
	ENSPREP00000008631	Sodium leak channel, non-selective. (578 aa)
	ENSPREP00000008810	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (962 aa)
	LOC103474059	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (270 aa)
	ENSPREP00000009542	Leucine rich repeat transmembrane neuronal 2. (546 aa)
	LOC103469220	Calcium channel, voltage-dependent, gamma subunit 5b. (333 aa)
	igsf11	Immunoglobulin superfamily member 11. (493 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (229 aa)
	LOC103478060	Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, b. (1839 aa)
	LOC103478058	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (341 aa)
	CRTC1	CREB regulated transcription coactivator 1b. (688 aa)
	LOC103467387	Leucine rich repeat transmembrane neuronal 1. (524 aa)
	LOC103481634	Uncharacterized protein. (1385 aa)
	LOC103479167	CREB regulated transcription coactivator 1a. (518 aa)
	LOC103463403	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1126 aa)
	LOC103466550	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (727 aa)
	rims1	Regulating synaptic membrane exocytosis 1a. (1422 aa)
	ENSPREP00000014846	Uncharacterized protein. (703 aa)
	Lama2	Laminin_I domain-containing protein. (123 aa)
	ENSPREP00000014939	Uncharacterized protein. (860 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	LOC103466551	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (621 aa)
	LOC103474919	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (762 aa)
	clstn2	Uncharacterized protein. (945 aa)
	rapsn	Receptor-associated protein of the synapse, 43kD. (395 aa)
	sqstm1	Sequestosome 1. (500 aa)
	syt12	Synaptotagmin XII. (423 aa)
	mecp2	Methyl CpG binding protein 2. (982 aa)
	stx1b	Syntaxin 1B; Belongs to the syntaxin family. (312 aa)
	LOC103468798	Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b. (1596 aa)
	LOC103469050	Glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca. (1414 aa)
	LOC103461055	Fragile X mental retardation 1. (400 aa)
	LOC103479345	Calsyntenin 2. (867 aa)
	clstn1	Calsyntenin 1. (958 aa)
	LOC103472577	Uncharacterized protein. (1105 aa)
	LOC103466432	Si:ch73-330k17.3. (167 aa)
	LOC103466425	Uncharacterized protein. (380 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1303 aa)
	grin2b	Uncharacterized protein. (1706 aa)
	RELN	Reelin. (3446 aa)
	stx3	Syntaxin 3A; Belongs to the syntaxin family. (323 aa)
	LOC103476861	Leucine-rich, glioma inactivated 1a. (554 aa)
	lgmn	Legumain. (437 aa)
	grin2a	Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a. (1552 aa)
	SLC24A1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (771 aa)
	cacng3	Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (633 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (570 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	LOC103466207	Teashirt zinc finger homeobox 3a. (1112 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001630	Nfatc4	ENSPREP00000001630	ENSPREP00000001665	RHD domain-containing protein.	Uncharacterized protein.	0.865
ENSPREP00000001630	sqstm1	ENSPREP00000001630	ENSPREP00000016733	RHD domain-containing protein.	Sequestosome 1.	0.468
ENSPREP00000008631	LOC103479055	ENSPREP00000008631	ENSPREP00000008524	Sodium leak channel, non-selective.	Sodium leak channel, non-selective.	0.946
ENSPREP00000008810	LOC103457562	ENSPREP00000008810	ENSPREP00000001452	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.438
ENSPREP00000008810	LOC103481184	ENSPREP00000008810	ENSPREP00000015196	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.443
ENSPREP00000008810	adcy8	ENSPREP00000008810	ENSPREP00000030665	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.434
ENSPREP00000014846	ENSPREP00000014939	ENSPREP00000014846	ENSPREP00000014939	Uncharacterized protein.	Uncharacterized protein.	0.921
ENSPREP00000014846	Lama2	ENSPREP00000014846	ENSPREP00000014859	Uncharacterized protein.	Laminin_I domain-containing protein.	0.900
ENSPREP00000014939	ENSPREP00000014846	ENSPREP00000014939	ENSPREP00000014846	Uncharacterized protein.	Uncharacterized protein.	0.921
ENSPREP00000014939	Lama2	ENSPREP00000014939	ENSPREP00000014859	Uncharacterized protein.	Laminin_I domain-containing protein.	0.899
LOC103457562	ENSPREP00000008810	ENSPREP00000001452	ENSPREP00000008810	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.438
LOC103457562	LOC103463403	ENSPREP00000001452	ENSPREP00000014016	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.440
LOC103461055	fmr1	ENSPREP00000020915	ENSPREP00000004643	Fragile X mental retardation 1.	Fragile X mental retardation 1.	0.932
LOC103461055	mecp2	ENSPREP00000020915	ENSPREP00000018569	Fragile X mental retardation 1.	Methyl CpG binding protein 2.	0.461
LOC103462623	LOC103468798	ENSPREP00000000034	ENSPREP00000018974	Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b.	Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b.	0.591
LOC103462623	LOC103481634	ENSPREP00000000034	ENSPREP00000013842	Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b.	Uncharacterized protein.	0.401
LOC103462623	grin2b	ENSPREP00000000034	ENSPREP00000024202	Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b.	Uncharacterized protein.	0.583
LOC103462684	LOC103476861	ENSPREP00000007723	ENSPREP00000026494	Neuroplastin b.	Leucine-rich, glioma inactivated 1a.	0.476
LOC103463403	LOC103457562	ENSPREP00000014016	ENSPREP00000001452	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.440
LOC103463403	LOC103481184	ENSPREP00000014016	ENSPREP00000015196	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.445