(36 nodes) Regulation of steroid biosynthetic process network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC103481463	START domain-containing protein. (272 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (427 aa)
	LOC103475277	ATP-binding cassette, sub-family G (WHITE), member 1. (620 aa)
	LOC103466252	Dickkopf WNT signaling pathway inhibitor 3b. (257 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	sirt1	Sirtuin 1. (677 aa)
	sf1	Splicing factor 1. (676 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1207 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	apob	Apolipoprotein Ba. (4338 aa)
	LOC103457447	Apolipoprotein Bb, tandem duplicate 2. (3356 aa)
	ENSPREP00000010257	Uncharacterized protein. (434 aa)
	ENSPREP00000010344	Vitellogenin domain-containing protein. (759 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (307 aa)
	SNAI2	Snail family transcriptional repressor 2. (272 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
	armc5	Armadillo repeat containing 5. (841 aa)
	DGKQ	Diacylglycerol kinase. (895 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (464 aa)
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	podn	Podocan. (587 aa)
	ENSPREP00000021170	Uncharacterized protein. (167 aa)
	Srebf2	Uncharacterized protein. (209 aa)
	ENSPREP00000024568	BHLH domain-containing protein. (197 aa)
	rusc1	RUN and SH3 domain containing 1. (655 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	scap	SREBF chaperone. (1264 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (127 aa)
	abcg4	ATP-binding cassette, sub-family G (WHITE), member 4a. (649 aa)
	LOC103462479	Dickkopf WNT signaling pathway inhibitor 3a. (275 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006768	fgf19	ENSPREP00000006768	ENSPREP00000002527	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.487
ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	Uncharacterized protein.	Vitellogenin domain-containing protein.	0.739
ENSPREP00000010257	ENSPREP00000030224	ENSPREP00000010257	ENSPREP00000030224	Uncharacterized protein.	PID domain-containing protein.	0.475
ENSPREP00000010257	LOC103473017	ENSPREP00000010257	ENSPREP00000013094	Uncharacterized protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010257	LOC103477848	ENSPREP00000010257	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.757
ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	Vitellogenin domain-containing protein.	Uncharacterized protein.	0.739
ENSPREP00000010344	ENSPREP00000030224	ENSPREP00000010344	ENSPREP00000030224	Vitellogenin domain-containing protein.	PID domain-containing protein.	0.475
ENSPREP00000010344	LOC103473017	ENSPREP00000010344	ENSPREP00000013094	Vitellogenin domain-containing protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010344	LOC103477848	ENSPREP00000010344	ENSPREP00000006664	Vitellogenin domain-containing protein.	Apolipoprotein Eb.	0.757
ENSPREP00000021170	igf2	ENSPREP00000021170	ENSPREP00000029568	Uncharacterized protein.	IlGF domain-containing protein.	0.445
ENSPREP00000024568	Srebf2	ENSPREP00000024568	ENSPREP00000024531	BHLH domain-containing protein.	Uncharacterized protein.	0.900
ENSPREP00000024568	scap	ENSPREP00000024568	ENSPREP00000029624	BHLH domain-containing protein.	SREBF chaperone.	0.941
ENSPREP00000024568	sirt1	ENSPREP00000024568	ENSPREP00000003960	BHLH domain-containing protein.	Sirtuin 1.	0.440
ENSPREP00000024568	srebf1	ENSPREP00000024568	ENSPREP00000007886	BHLH domain-containing protein.	Sterol regulatory element binding transcription factor 1.	0.420
ENSPREP00000030224	ENSPREP00000010257	ENSPREP00000030224	ENSPREP00000010257	PID domain-containing protein.	Uncharacterized protein.	0.475
ENSPREP00000030224	ENSPREP00000010344	ENSPREP00000030224	ENSPREP00000010344	PID domain-containing protein.	Vitellogenin domain-containing protein.	0.475
ENSPREP00000030224	LOC103457447	ENSPREP00000030224	ENSPREP00000009874	PID domain-containing protein.	Apolipoprotein Bb, tandem duplicate 2.	0.475
ENSPREP00000030224	LOC103462479	ENSPREP00000030224	ENSPREP00000034164	PID domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 3a.	0.428
ENSPREP00000030224	LOC103466252	ENSPREP00000030224	ENSPREP00000002449	PID domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 3b.	0.428
ENSPREP00000030224	apob	ENSPREP00000030224	ENSPREP00000008121	PID domain-containing protein.	Apolipoprotein Ba.	0.475