(111 nodes) Protein stabilization network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hps4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (616 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (779 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	phb	Prohibitin. (271 aa)
	hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (723 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	LOC103475241	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
	LOC103470262	Huntingtin interacting protein 1 related b. (1028 aa)
	lamp1	Lysosomal associated membrane protein 1a. (409 aa)
	ENSPREP00000012772	GRANULINS domain-containing protein. (152 aa)
	Grn	Uncharacterized protein. (68 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	LOC103479821	Clusterin; Belongs to the clusterin family. (464 aa)
	LOC103468475	Tetraspanin. (244 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LOC103473710	AP2 associated kinase 1b. (1079 aa)
	LOC103469510	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (452 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit. (864 aa)
	Morc3	Uncharacterized protein. (160 aa)
	dnlz	DNL-type zinc finger. (191 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	LOC103458635	Zgc:154055. (576 aa)
	bag3	BCL2 associated athanogene 3. (516 aa)
	LOC103472251	Uncharacterized protein. (260 aa)
	LOC103459886	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (253 aa)
	pim1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	bag6	BCL2 associated athanogene 6. (1194 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	LOC103477850	Uncharacterized protein. (255 aa)
	LOC103477849	Uncharacterized protein. (255 aa)
	apopt1	Cytochrome c oxidase assembly factor 8. (195 aa)
	bag5	BCL2 associated athanogene 5. (481 aa)
	tesc	Tescalcin a. (217 aa)
	camlg	Calcium modulating ligand. (281 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	rab21	RAB21, member RAS oncogene family. (220 aa)
	park7	Parkinson protein 7. (189 aa)
	CDC37	Cell division cycle 37 homolog (S. cerevisiae). (375 aa)
	LOC103471157	N(alpha)-acetyltransferase 15, NatA auxiliary subunit a. (868 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	aak1	AP2 associated kinase 1a. (1055 aa)
	atp1b3	Uncharacterized protein. (458 aa)
	LOC103474828	Apolipoprotein A-Ib. (263 aa)
	ENSPREP00000011325	CLa domain-containing protein. (300 aa)
	LOC103472976	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (350 aa)
	cdc37l1	Cell division cycle 37-like 1. (360 aa)
	LOC103457917	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (767 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (496 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (528 aa)
	tmem88	Uncharacterized protein. (228 aa)
	usp13	Ubiquitinyl hydrolase 1. (867 aa)
	clu	Clusterin; Belongs to the clusterin family. (369 aa)
	glmp	Glycosylated lysosomal membrane protein. (396 aa)
	cct3	T-complex protein 1 subunit gamma. (540 aa)
	znf207	Zinc finger protein 207, b. (473 aa)
	stxbp4	Syntaxin binding protein 4. (705 aa)
	chek2	Checkpoint kinase 2. (510 aa)
	ENSPREP00000024075	Morc6_S5 domain-containing protein. (305 aa)
	LOC103475775	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (285 aa)
	bag2	BCL2 associated athanogene 2. (208 aa)
	a1cf	Apobec1 complementation factor. (614 aa)
	LOC103478167	Ephrin-A1b; Belongs to the ephrin family. (232 aa)
	sav1	Salvador family WW domain containing protein 1. (383 aa)
	LOC103475461	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	hypk	Huntingtin interacting protein K. (121 aa)
	LOC103470753	Uncharacterized protein. (486 aa)
	hip1	Huntingtin interacting protein 1. (1050 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (969 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (783 aa)
	LOC103481098	Im:7160594. (418 aa)
	chp1	Calcineurin-like EF-hand protein 1. (154 aa)
	mtmr9	Myotubularin related protein 9. (549 aa)
	atf7ip2	Fibronectin type-III domain-containing protein. (381 aa)
	pex19	Peroxisomal biogenesis factor 19. (283 aa)
	ENSPREP00000000154	Uncharacterized protein. (266 aa)
	LOC103464523	Si:dkey-217d24.6. (782 aa)
	ENSPREP00000001288	Uncharacterized protein. (203 aa)
	mfsd1	Major facilitator superfamily domain containing 1. (523 aa)
	cog3	Component of oligomeric golgi complex 3. (833 aa)
	LOC103475866	Transmembrane protein 88 a. (189 aa)
	trim44	Tripartite motif containing 44. (357 aa)
	cog7	Component of oligomeric golgi complex 7. (767 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1186 aa)
	LOC103472698	Ephrin-A1a; Belongs to the ephrin family. (221 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (604 aa)
	sugt1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (323 aa)
	LOC103461010	Uncharacterized protein. (283 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	LOC103476970	Muscle segment homeobox 3. (212 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	ENSPREP00000013992	Uncharacterized protein. (686 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	LOC103468998	Uncharacterized protein. (812 aa)
	LOC103476762	ALMS_motif domain-containing protein. (417 aa)
	bag4	BCL2 associated athanogene 4. (377 aa)
	otud3	OTU deubiquitinase 3. (329 aa)
	ENSPREP00000014929	Wolfram syndrome 1a (wolframin). (784 aa)
	lamp2	Lysosomal-associated membrane protein 2. (411 aa)
	atf7ip	Activating transcription factor 7 interacting protein. (958 aa)
	LOC103473749	Tescalcin b. (252 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	LOC103468326	Tetraspanin. (246 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	swsap1	SWIM-type zinc finger 7 associated protein 1. (271 aa)
	TMEM19	Transmembrane protein 19. (305 aa)
	pex6	Peroxisomal biogenesis factor 6. (1057 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC37	HSP90AA1	ENSPREP00000009925	ENSPREP00000020973	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90 alpha family class A member 1.	0.879
CDC37	LOC103457917	ENSPREP00000009925	ENSPREP00000020946	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.879
CDC37	hsp90ab1	ENSPREP00000009925	ENSPREP00000012481	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.874
CDC37	pink1	ENSPREP00000009925	ENSPREP00000032869	Cell division cycle 37 homolog (S. cerevisiae).	PTEN induced kinase 1.	0.610
CDC37	tsc1	ENSPREP00000009925	ENSPREP00000032075	Cell division cycle 37 homolog (S. cerevisiae).	TSC complex subunit 1b.	0.766
ENSPREP00000000154	HSP90AA1	ENSPREP00000000154	ENSPREP00000020973	Uncharacterized protein.	Heat shock protein 90 alpha family class A member 1.	0.766
ENSPREP00000000154	LOC103457917	ENSPREP00000000154	ENSPREP00000020946	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.766
ENSPREP00000000154	hsp90ab1	ENSPREP00000000154	ENSPREP00000012481	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.766
ENSPREP00000000154	pink1	ENSPREP00000000154	ENSPREP00000032869	Uncharacterized protein.	PTEN induced kinase 1.	0.574
ENSPREP00000000154	tsc1	ENSPREP00000000154	ENSPREP00000032075	Uncharacterized protein.	TSC complex subunit 1b.	0.766
ENSPREP00000001288	ENSPREP00000024075	ENSPREP00000001288	ENSPREP00000024075	Uncharacterized protein.	Morc6_S5 domain-containing protein.	0.423
ENSPREP00000001288	Morc3	ENSPREP00000001288	ENSPREP00000001317	Uncharacterized protein.	Uncharacterized protein.	0.739
ENSPREP00000020277	HSP90AA1	ENSPREP00000020277	ENSPREP00000020973	RBR-type E3 ubiquitin transferase.	Heat shock protein 90 alpha family class A member 1.	0.443
ENSPREP00000020277	LOC103457917	ENSPREP00000020277	ENSPREP00000020946	RBR-type E3 ubiquitin transferase.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.443
ENSPREP00000020277	bag5	ENSPREP00000020277	ENSPREP00000007725	RBR-type E3 ubiquitin transferase.	BCL2 associated athanogene 5.	0.478
ENSPREP00000020277	hsp90ab1	ENSPREP00000020277	ENSPREP00000012481	RBR-type E3 ubiquitin transferase.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.443
ENSPREP00000020277	mul1	ENSPREP00000020277	ENSPREP00000031865	RBR-type E3 ubiquitin transferase.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.690
ENSPREP00000020277	park7	ENSPREP00000020277	ENSPREP00000008597	RBR-type E3 ubiquitin transferase.	Parkinson protein 7.	0.929
ENSPREP00000020277	pink1	ENSPREP00000020277	ENSPREP00000032869	RBR-type E3 ubiquitin transferase.	PTEN induced kinase 1.	0.996
ENSPREP00000024075	ENSPREP00000001288	ENSPREP00000024075	ENSPREP00000001288	Morc6_S5 domain-containing protein.	Uncharacterized protein.	0.423