(40 nodes) Defense response to Gram-positive bacterium network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473985	Phospholipase A(2). (149 aa)
	ENSPREP00000003758	Pyrin domain-containing protein. (110 aa)
	LOC103474747	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (203 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	LOC103474046	Fibronectin type-III domain-containing protein. (440 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (996 aa)
	ENSPREP00000013211	Uncharacterized protein. (205 aa)
	ENSPREP00000013232	Uncharacterized protein. (168 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (884 aa)
	ENSPREP00000018072	Uncharacterized protein. (672 aa)
	ENSPREP00000018330	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (150 aa)
	ENSPREP00000018476	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (153 aa)
	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (121 aa)
	ENSPREP00000018907	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (140 aa)
	ENSPREP00000018914	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (131 aa)
	LOC103472625	Jacalin-type lectin domain-containing protein. (163 aa)
	ENSPREP00000019132	Jacalin-type lectin domain-containing protein. (160 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	LOC103470686	Interleukin-1. (247 aa)
	ENSPREP00000019657	Uncharacterized protein. (253 aa)
	LOC103468351	Peptidoglycan recognition protein 6. (477 aa)
	ENSPREP00000021617	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (130 aa)
	ENSPREP00000021634	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (128 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	IL18	Uncharacterized protein. (218 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	LOC103470783	CARD domain-containing protein. (434 aa)
	mpeg1	Macrophage expressed 1, tandem duplicate 2. (728 aa)
	LOC103467691	Peptidoglycan recognition protein 2. (489 aa)
	LOC103457773	Uncharacterized protein. (156 aa)
	ENSPREP00000029074	Tumor necrosis factor a (TNF superfamily, member 2). (228 aa)
	ppp1r11	Protein phosphatase 1, regulatory (inhibitor) subunit 11. (123 aa)
	PLA2G1B	Phospholipase A(2). (147 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	LOC103457268	Si:ch211-108d22.2. (2793 aa)
	drosha	Drosha ribonuclease III. (1312 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
ENSPREP00000003758	LOC103470686	ENSPREP00000003758	ENSPREP00000019387	Pyrin domain-containing protein.	Interleukin-1.	0.619
ENSPREP00000013211	ENSPREP00000013232	ENSPREP00000013211	ENSPREP00000013232	Uncharacterized protein.	Uncharacterized protein.	0.730
ENSPREP00000013211	LOC103457773	ENSPREP00000013211	ENSPREP00000028567	Uncharacterized protein.	Uncharacterized protein.	0.735
ENSPREP00000013211	LOC103473985	ENSPREP00000013211	ENSPREP00000000776	Uncharacterized protein.	Phospholipase A(2).	0.487
ENSPREP00000013232	ENSPREP00000013211	ENSPREP00000013232	ENSPREP00000013211	Uncharacterized protein.	Uncharacterized protein.	0.730
ENSPREP00000013232	LOC103457773	ENSPREP00000013232	ENSPREP00000028567	Uncharacterized protein.	Uncharacterized protein.	0.907
ENSPREP00000013232	LOC103470686	ENSPREP00000013232	ENSPREP00000019387	Uncharacterized protein.	Interleukin-1.	0.437
ENSPREP00000013232	LOC103473985	ENSPREP00000013232	ENSPREP00000000776	Uncharacterized protein.	Phospholipase A(2).	0.488
ENSPREP00000018072	LOC103470783	ENSPREP00000018072	ENSPREP00000025510	Uncharacterized protein.	CARD domain-containing protein.	0.531
ENSPREP00000018072	ripk2	ENSPREP00000018072	ENSPREP00000009886	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.808
ENSPREP00000018330	ENSPREP00000018877	ENSPREP00000018330	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.845
ENSPREP00000018877	ENSPREP00000018330	ENSPREP00000018877	ENSPREP00000018330	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.845
ENSPREP00000018877	ENSPREP00000018907	ENSPREP00000018877	ENSPREP00000018907	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.847
ENSPREP00000018877	ENSPREP00000018914	ENSPREP00000018877	ENSPREP00000018914	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.844
ENSPREP00000018877	ENSPREP00000021617	ENSPREP00000018877	ENSPREP00000021617	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.846
ENSPREP00000018877	ENSPREP00000021634	ENSPREP00000018877	ENSPREP00000021634	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.844
ENSPREP00000018907	ENSPREP00000018877	ENSPREP00000018907	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.847
ENSPREP00000018914	ENSPREP00000018877	ENSPREP00000018914	ENSPREP00000018877	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.844