(89 nodes) Positive regulation of T cell activation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103474046	Fibronectin type-III domain-containing protein. (440 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	snx12	Fibronectin type-III domain-containing protein. (355 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	ENSPREP00000010906	MHC_II_beta domain-containing protein. (113 aa)
	LOC103466618	MALT paracaspase 3. (573 aa)
	LOC103469935	MALT paracaspase 1. (828 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	LOC103480349	Ig-like domain-containing protein. (420 aa)
	LOC103468233	Tyrosine-protein kinase. (606 aa)
	ENSPREP00000013399	Uncharacterized protein. (453 aa)
	nck2	Cytoplasmic protein. (393 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	LOC103480933	Ig-like domain-containing protein. (276 aa)
	LOC103460899	Ig-like domain-containing protein. (241 aa)
	LOC103476935	ZP domain-containing protein. (392 aa)
	LOC103471589	CD40 ligand; Belongs to the tumor necrosis factor family. (237 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (597 aa)
	ENSPREP00000017250	Uncharacterized protein. (223 aa)
	ENSPREP00000017269	Ig-like domain-containing protein. (228 aa)
	ENSPREP00000017286	Uncharacterized protein. (243 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	LOC103476207	Si:dkey-175m17.7. (913 aa)
	ENSPREP00000017725	Ig-like domain-containing protein. (267 aa)
	il6st	Uncharacterized protein. (896 aa)
	ENSPREP00000018176	Uncharacterized protein. (394 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1230 aa)
	ENSPREP00000018398	MALT paracaspase 2. (715 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (681 aa)
	LOC103470686	Interleukin-1. (247 aa)
	SLC7A1	Solute carrier family 7 member 1. (633 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	ENSPREP00000021306	Si:dkeyp-44d3.5. (895 aa)
	LOC103475508	Solute carrier family 7 member 1a. (592 aa)
	LOC103466036	ZP domain-containing protein. (423 aa)
	LOC103480564	Ephrin-B3a; Belongs to the ephrin family. (338 aa)
	IL18	Uncharacterized protein. (218 aa)
	LGALS2	Galectin. (140 aa)
	LOC103478681	Ig-like domain-containing protein. (245 aa)
	ENSPREP00000026345	Ig-like domain-containing protein. (116 aa)
	LOC103478678	Uncharacterized protein. (255 aa)
	LOC103478679	Ig-like domain-containing protein. (243 aa)
	ENSPREP00000026423	Ig-like domain-containing protein. (260 aa)
	gata3	GATA binding protein 3. (483 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	TGFBR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	cd83	CD83 molecule. (228 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	cbfb	Core-binding factor subunit beta. (184 aa)
	LOC103477681	ANK_REP_REGION domain-containing protein. (435 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (271 aa)
	hspd1	Heat shock 60 protein 1; Belongs to the chaperonin (HSP60) family. (575 aa)
	ENSPREP00000029286	HERV-H LTR-associating 2a, tandem duplicate 2. (348 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1210 aa)
	efnb1	Ephrin-B1; Belongs to the ephrin family. (376 aa)
	nck1	Cytoplasmic protein. (394 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	ENSPREP00000033319	Uncharacterized protein. (272 aa)
	ENSPREP00000033333	Ig-like domain-containing protein. (256 aa)
	ENSPREP00000033336	Ig-like domain-containing protein. (111 aa)
	ENSPREP00000033751	Uncharacterized protein. (433 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	ENSPREP00000033777	Uncharacterized protein. (266 aa)
	ENSPREP00000033788	Uncharacterized protein. (447 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (756 aa)
	LOC103462560	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (319 aa)
	LOC103468616	Galectin. (176 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	vsir	V-set immunoregulatory receptor. (291 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	LOC103469798	SCY domain-containing protein. (110 aa)
	AIF1	Allograft inflammatory factor 1. (149 aa)
	Cav1	Uncharacterized protein. (84 aa)
	ENSPREP00000004255	ANK_REP_REGION domain-containing protein. (314 aa)
	syk	Tyrosine-protein kinase. (614 aa)
	xbp1	X-box binding protein 1. (385 aa)
	LOC103463734	Interleukin 12 receptor, beta 2a. (785 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	cd276	CD276 molecule. (298 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC103470686	ENSPREP00000003783	ENSPREP00000019387	Allograft inflammatory factor 1.	Interleukin-1.	0.579
AIF1	ptprc	ENSPREP00000003783	ENSPREP00000018309	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.471
Cav1	cav3	ENSPREP00000003891	ENSPREP00000013872	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
ENSPREP00000002275	LOC103468233	ENSPREP00000002275	ENSPREP00000012417	DED domain-containing protein.	Tyrosine-protein kinase.	0.597
ENSPREP00000002275	ripk2	ENSPREP00000002275	ENSPREP00000009886	DED domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.710
ENSPREP00000002275	syk	ENSPREP00000002275	ENSPREP00000006334	DED domain-containing protein.	Tyrosine-protein kinase.	0.597
ENSPREP00000010906	ENSPREP00000026423	ENSPREP00000010906	ENSPREP00000026423	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.554
ENSPREP00000010906	LOC103478678	ENSPREP00000010906	ENSPREP00000026357	MHC_II_beta domain-containing protein.	Uncharacterized protein.	0.584
ENSPREP00000010906	LOC103478679	ENSPREP00000010906	ENSPREP00000026374	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.885
ENSPREP00000010906	LOC103478681	ENSPREP00000010906	ENSPREP00000026336	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.876
ENSPREP00000010906	LOC103480933	ENSPREP00000010906	ENSPREP00000014548	MHC_II_beta domain-containing protein.	Ig-like domain-containing protein.	0.878
ENSPREP00000010906	ptprc	ENSPREP00000010906	ENSPREP00000018309	MHC_II_beta domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.411
ENSPREP00000013399	LOC103475119	ENSPREP00000013399	ENSPREP00000027136	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.422
ENSPREP00000013399	LOC103478679	ENSPREP00000013399	ENSPREP00000026374	Uncharacterized protein.	Ig-like domain-containing protein.	0.417
ENSPREP00000013399	LOC103478681	ENSPREP00000013399	ENSPREP00000026336	Uncharacterized protein.	Ig-like domain-containing protein.	0.417
ENSPREP00000013399	LOC103480933	ENSPREP00000013399	ENSPREP00000014548	Uncharacterized protein.	Ig-like domain-containing protein.	0.417
ENSPREP00000013399	ptprc	ENSPREP00000013399	ENSPREP00000018309	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.478
ENSPREP00000018176	LOC103470686	ENSPREP00000018176	ENSPREP00000019387	Uncharacterized protein.	Interleukin-1.	0.425
ENSPREP00000018398	ENSPREP00000027430	ENSPREP00000018398	ENSPREP00000027430	MALT paracaspase 2.	CARD domain-containing protein.	0.784
ENSPREP00000018398	LOC103468233	ENSPREP00000018398	ENSPREP00000012417	MALT paracaspase 2.	Tyrosine-protein kinase.	0.404