(50 nodes) Negative regulation of chemotaxis network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000005219	SCY domain-containing protein. (98 aa)
	sema3b	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (809 aa)
	sema3f	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (790 aa)
	LOC103467700	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga; Belongs to the semaphorin family. (741 aa)
	AIF1	Allograft inflammatory factor 1. (149 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (746 aa)
	LOC103465510	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (699 aa)
	GREM1	Gremlin. (182 aa)
	sema6c	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1086 aa)
	LOC103477638	Si:ch211-113g11.6; Belongs to the semaphorin family. (609 aa)
	inppl1	Inositol polyphosphate phosphatase-like 1a. (1248 aa)
	mmp28	Matrix metallopeptidase 28. (454 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (863 aa)
	LOC103476866	Uncharacterized protein; Belongs to the semaphorin family. (887 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (239 aa)
	LOC103472534	Sema domain-containing protein; Belongs to the semaphorin family. (1152 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (900 aa)
	LOC103471376	Uncharacterized protein. (383 aa)
	ryk	Receptor like tyrosine kinase. (632 aa)
	sema5a	Sema domain-containing protein. (1153 aa)
	LOC103459228	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (856 aa)
	sema3e	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (675 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (799 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (794 aa)
	sema6a	Semaphorin 6A; Belongs to the semaphorin family. (1011 aa)
	LOC103477509	Uncharacterized protein; Belongs to the semaphorin family. (572 aa)
	LOC103467133	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H; Belongs to the semaphorin family. (689 aa)
	LOC103479279	Semaphorin 4e; Belongs to the semaphorin family. (759 aa)
	LOC103479272	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (899 aa)
	sema4a	Sema domain-containing protein; Belongs to the semaphorin family. (815 aa)
	LOC103475124	Sema domain-containing protein. (1092 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
	sema6d	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1048 aa)
	sema4g	Uncharacterized protein; Belongs to the semaphorin family. (883 aa)
	CCN3	Cellular communication network factor 3. (349 aa)
	LOC103464644	Si:dkey-49n23.1; Belongs to the semaphorin family. (731 aa)
	ENSPREP00000014353	Semaphorin 7A; Belongs to the semaphorin family. (366 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (870 aa)
	LOC103462612	Uncharacterized protein; Belongs to the semaphorin family. (615 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC103466628	Sema domain-containing protein; Belongs to the semaphorin family. (834 aa)
	LOC103463726	Si:ch211-129c21.1; Belongs to the semaphorin family. (759 aa)
	gpr18	G protein-coupled receptor 18. (339 aa)
	LOC103460673	VPS9 domain-containing protein. (710 aa)
	LOC103459977	Sema domain-containing protein; Belongs to the semaphorin family. (625 aa)
	LOC103462179	Sema domain-containing protein; Belongs to the semaphorin family. (838 aa)
	sema3g	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (784 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (841 aa)
	sema5b	Sema domain-containing protein. (1032 aa)
	c5	Anaphylatoxin-like domain-containing protein. (1413 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ryk	wnt3	ENSPREP00000022759	ENSPREP00000017531	Receptor like tyrosine kinase.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.752
ryk	wnt3a	ENSPREP00000022759	ENSPREP00000011284	Receptor like tyrosine kinase.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.752
wnt3	ryk	ENSPREP00000017531	ENSPREP00000022759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.752
wnt3a	ryk	ENSPREP00000011284	ENSPREP00000022759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.752