(75 nodes) Positive regulation of binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ripor3	RIPOR family member 3. (1001 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	pkd1	Polycystic kidney disease 1a. (4592 aa)
	ENSPREP00000001578	PL48 domain-containing protein. (371 aa)
	LOC103466243	Uncharacterized protein. (782 aa)
	Cav1	Uncharacterized protein. (84 aa)
	ide	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1064 aa)
	fmr1	Fragile X mental retardation 1. (273 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	men1	Multiple endocrine neoplasia I. (627 aa)
	LOC103478486	Uncharacterized protein. (208 aa)
	LOC103475974	Thioredoxin; Belongs to the thioredoxin family. (132 aa)
	LOC103475976	Thioredoxin; Belongs to the thioredoxin family. (103 aa)
	ENSPREP00000006378	Thioredoxin domain-containing protein. (133 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	ENSPREP00000008376	Uncharacterized protein. (208 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (718 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	cln5	CLN5 intracellular trafficking protein. (335 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	ripor1	RHO family interacting cell polarization regulator 1. (1094 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	gtf2b	General transcription factor IIB. (318 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1615 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (620 aa)
	gmnn	Geminin DNA replication inhibitor. (209 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (1067 aa)
	nvl	Nuclear VCP like; Belongs to the AAA ATPase family. (670 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	larp6	La ribonucleoprotein domain family, member 6a. (687 aa)
	LOC103475650	Vitronectin b. (444 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (377 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	sppl3	Signal peptide peptidase 3. (383 aa)
	egf	Epidermal growth factor. (942 aa)
	pinlyp	Uncharacterized protein. (208 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	clic2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
	bambi	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (278 aa)
	spon1	Spondin 1a. (806 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	LOC103461055	Fragile X mental retardation 1. (400 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	LOC103464789	Tribbles pseudokinase 3. (351 aa)
	ENSPREP00000022539	RING-type domain-containing protein. (198 aa)
	ENSPREP00000022564	RING-type domain-containing protein. (200 aa)
	ENSPREP00000022586	RING-type domain-containing protein. (205 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	znf618	Zinc finger protein 618. (852 aa)
	gpsm1	G protein signaling modulator 1b. (662 aa)
	edf1	Endothelial differentiation-related factor 1. (148 aa)
	LOC103469642	Si:dkey-3h3.3. (444 aa)
	myocd	SAP domain-containing protein. (936 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	ENSPREP00000026918	Uncharacterized protein. (130 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (378 aa)
	LOC103466742	Uncharacterized protein. (442 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1216 aa)
	LOC103472693	Protein S100; Belongs to the S-100 family. (100 aa)
	LOC103472707	Pygopus homolog 2 (Drosophila). (588 aa)
	LOC108166784	Sperm associated antigen 8. (183 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	vtn	Vitronectin a. (568 aa)
	LOC103467314	RING-type domain-containing protein. (198 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	LOC103467312	Zgc:66440. (395 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	Cldn5	ENSPREP00000003891	ENSPREP00000017247	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.468
Cav1	LOC103473180	ENSPREP00000003891	ENSPREP00000020548	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.468
Cav1	LOC103477848	ENSPREP00000003891	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.418
Cav1	egf	ENSPREP00000003891	ENSPREP00000015161	Uncharacterized protein.	Epidermal growth factor.	0.419
Cldn5	Cav1	ENSPREP00000017247	ENSPREP00000003891	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.468
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
ENSPREP00000008376	LOC103475650	ENSPREP00000008376	ENSPREP00000012682	Uncharacterized protein.	Vitronectin b.	0.692
ENSPREP00000008376	vtn	ENSPREP00000008376	ENSPREP00000032231	Uncharacterized protein.	Vitronectin a.	0.692
ENSPREP00000020277	cdk5	ENSPREP00000020277	ENSPREP00000011776	RBR-type E3 ubiquitin transferase.	Cyclin-dependent kinase 5.	0.442
ENSPREP00000020277	lrrk2	ENSPREP00000020277	ENSPREP00000005307	RBR-type E3 ubiquitin transferase.	Leucine-rich repeat kinase 2.	0.606
ENSPREP00000020277	ripk2	ENSPREP00000020277	ENSPREP00000009886	RBR-type E3 ubiquitin transferase.	Receptor-interacting serine-threonine kinase 2.	0.460
ENSPREP00000032744	abl1	ENSPREP00000032744	ENSPREP00000021197	Retinoblastoma 1.	Tyrosine-protein kinase.	0.939
ENSPREP00000032744	abl2	ENSPREP00000032744	ENSPREP00000026823	Retinoblastoma 1.	Tyrosine-protein kinase.	0.423
ENSPREP00000032744	cdt1	ENSPREP00000032744	ENSPREP00000011428	Retinoblastoma 1.	Chromatin licensing and DNA replication factor 1.	0.595
LOC103461055	fmr1	ENSPREP00000020915	ENSPREP00000004643	Fragile X mental retardation 1.	Fragile X mental retardation 1.	0.932
LOC103468460	LOC103475119	ENSPREP00000026558	ENSPREP00000027136	E1A binding protein p300 b.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.523
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	gtf2b	ENSPREP00000026558	ENSPREP00000011330	E1A binding protein p300 b.	General transcription factor IIB.	0.623
LOC103468460	kdm1a	ENSPREP00000026558	ENSPREP00000006670	E1A binding protein p300 b.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.660
LOC103468460	sirt2	ENSPREP00000026558	ENSPREP00000012959	E1A binding protein p300 b.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.466