(54 nodes) Negative regulation of protein transport network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bag3	BCL2 associated athanogene 3. (516 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103469840	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (234 aa)
	klf7	Kruppel-like factor 7b. (306 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (193 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	snx3	Sorting nexin 3. (162 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (276 aa)
	LOC103463687	Midnolin. (540 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (418 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
	rhbdf1	Rhomboid 5 homolog 1a (Drosophila). (898 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	ndfip2	Nedd4 family interacting protein 2. (247 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	bag4	BCL2 associated athanogene 4. (377 aa)
	CCN3	Cellular communication network factor 3. (349 aa)
	clg20h11orf65	Uncharacterized protein. (289 aa)
	bard1	BRCA1 associated RING domain 1. (722 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	ENSPREP00000019657	Uncharacterized protein. (253 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	sergef	Secretion regulating guanine nucleotide exchange factor. (411 aa)
	LOC103479802	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	svip	Si:ch73-147o17.1. (80 aa)
	cep131	Centrosomal protein 131. (1215 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (526 aa)
	ENSPREP00000024316	Rhomboid 5 homolog 1b (Drosophila). (732 aa)
	LOC103473404	Kruppel like factor 7. (293 aa)
	LOC103463031	Dopamine receptor D4a. (359 aa)
	os9	OS9 endoplasmic reticulum lectin. (705 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (162 aa)
	rangap1	RAN GTPase activating protein 1a. (575 aa)
	ube2g2	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast). (154 aa)
	LOC103473284	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	LOC103473499	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	drd3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	chp1	Calcineurin-like EF-hand protein 1. (154 aa)
	RHBDF2	Rhomboid 5 homolog 2. (801 aa)
	kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (372 aa)
	pkig	Protein kinase (cAMP-dependent, catalytic) inhibitor gamma. (127 aa)
	LOC103481999	Ran GTPase activating protein 1b. (567 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	rab23	RAB23, member RAS oncogene family. (204 aa)
	erlec1	Endoplasmic reticulum lectin 1. (498 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	gopc	Golgi-associated PDZ and coiled-coil motif containing. (445 aa)
	drd4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	ube2j1	Ubiquitin-conjugating enzyme E2, J1. (275 aa)
	LOC103477151	Uncharacterized protein. (158 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000020277	cdk5	ENSPREP00000020277	ENSPREP00000011776	RBR-type E3 ubiquitin transferase.	Cyclin-dependent kinase 5.	0.442
ENSPREP00000020277	lrrk2	ENSPREP00000020277	ENSPREP00000005307	RBR-type E3 ubiquitin transferase.	Leucine-rich repeat kinase 2.	0.606
ENSPREP00000020277	ube2g2	ENSPREP00000020277	ENSPREP00000027103	RBR-type E3 ubiquitin transferase.	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast).	0.681
ENSPREP00000020277	ube2j1	ENSPREP00000020277	ENSPREP00000001669	RBR-type E3 ubiquitin transferase.	Ubiquitin-conjugating enzyme E2, J1.	0.689
LOC103456761	LOC103473017	ENSPREP00000034008	ENSPREP00000013094	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family.	Apolipoprotein Ea.	0.450
LOC103456761	LOC103477848	ENSPREP00000034008	ENSPREP00000006664	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family.	Apolipoprotein Eb.	0.555
LOC103463031	drd3	ENSPREP00000025144	ENSPREP00000027769	Dopamine receptor D4a.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.660
LOC103469840	derl2	ENSPREP00000005741	ENSPREP00000009081	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.901
LOC103469840	erlec1	ENSPREP00000005741	ENSPREP00000033924	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.933
LOC103469840	os9	ENSPREP00000005741	ENSPREP00000025152	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.933
LOC103469840	ube2g2	ENSPREP00000005741	ENSPREP00000027103	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast).	0.440
LOC103469840	ube2j1	ENSPREP00000005741	ENSPREP00000001669	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2, J1.	0.512
LOC103473017	LOC103456761	ENSPREP00000013094	ENSPREP00000034008	Apolipoprotein Ea.	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family.	0.450
LOC103473284	hmgcr	ENSPREP00000027438	ENSPREP00000018171	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC103477848	LOC103456761	ENSPREP00000006664	ENSPREP00000034008	Apolipoprotein Eb.	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family.	0.555
LOC103477848	hmgcr	ENSPREP00000006664	ENSPREP00000018171	Apolipoprotein Eb.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.456
LOC103479463	sirt4	ENSPREP00000026036	ENSPREP00000003147	Sirtuin 6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.703
LOC103481999	rangap1	ENSPREP00000030639	ENSPREP00000026307	Ran GTPase activating protein 1b.	RAN GTPase activating protein 1a.	0.902
LOC103481999	ube2j1	ENSPREP00000030639	ENSPREP00000001669	Ran GTPase activating protein 1b.	Ubiquitin-conjugating enzyme E2, J1.	0.537
bag3	bag4	ENSPREP00000003708	ENSPREP00000014073	BCL2 associated athanogene 3.	BCL2 associated athanogene 4.	0.559