(51 nodes) Protein homotetramerization network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (335 aa)
	ssbp1	Single-stranded DNA binding protein 1. (163 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	LOC103467309	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	LOC103481993	Potassium inwardly-rectifying channel, subfamily J, member 12a. (434 aa)
	hsd17b10	Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	ENSPREP00000029973	VASP_tetra domain-containing protein. (201 aa)
	Enah	WH1 domain-containing protein. (115 aa)
	LOC103458826	ATP synthase inhibitory factor subunit 1b. (107 aa)
	thg1l	tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (295 aa)
	ENSPREP00000027416	HD domain-containing protein. (178 aa)
	LOC103467467	SAM domain and HD domain 1. (627 aa)
	LOC103467464	HD domain-containing protein. (433 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (442 aa)
	trpa1	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	LOC103462974	CREB regulated transcription coactivator 3. (697 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (338 aa)
	Cby1	Chibby homolog 1 (Drosophila). (189 aa)
	upb1	Ureidopropionase, beta. (383 aa)
	LOC103476358	Vasodilator stimulated phosphoprotein a. (381 aa)
	EVL	Enah/Vasp-like. (140 aa)
	ENSPREP00000023411	WH1 domain-containing protein. (134 aa)
	ENSPREP00000023386	VASP_tetra domain-containing protein. (51 aa)
	ENSPREP00000023207	LSDAT_euk domain-containing protein. (146 aa)
	ENSPREP00000022684	TORC_N domain-containing protein. (78 aa)
	cryz	Crystallin, zeta (quinone reductase). (328 aa)
	ENSPREP00000022126	Ion_trans domain-containing protein. (272 aa)
	ENSPREP00000022118	TORC_N domain-containing protein. (65 aa)
	CRTC2	CREB regulated transcription coactivator 2. (344 aa)
	LOC103464157	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (299 aa)
	LOC103469096	Uncharacterized protein. (424 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (835 aa)
	aldh9a1	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (505 aa)
	LOC103480496	Procollagen C-endopeptidase enhancer b. (456 aa)
	tdo2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (403 aa)
	LOC103478031	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family. (712 aa)
	trpm2	Transient receptor potential cation channel, subfamily M, member 2. (1460 aa)
	LOC103479167	CREB regulated transcription coactivator 1a. (518 aa)
	CRTC1	CREB regulated transcription coactivator 1b. (688 aa)
	shmt2	Serine hydroxymethyltransferase 2 (mitochondrial). (515 aa)
	acot13	Acyl-CoA thioesterase 13. (142 aa)
	LOC103481590	Potassium inwardly-rectifying channel, subfamily J, member 2a. (423 aa)
	LOC103467614	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
	LOC103467615	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
	LOC103479006	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family. (518 aa)
	ENSPREP00000005826	Vasodilator stimulated phosphoprotein b. (199 aa)
	ENSPREP00000004349	Potassium inwardly-rectifying channel, subfamily J, member 2b. (407 aa)
	LOC103477109	Polycystic kidney disease 2-like 1. (756 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (530 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2251 aa)
	tk1	Thymidine kinase. (233 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP4	LOC103467309	ENSPREP00000006988	ENSPREP00000032982	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.467
AQP4	LOC103467614	ENSPREP00000006988	ENSPREP00000010814	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.468
ENSPREP00000022126	ENSPREP00000023207	ENSPREP00000022126	ENSPREP00000023207	Ion_trans domain-containing protein.	LSDAT_euk domain-containing protein.	0.918
ENSPREP00000022126	LOC103478031	ENSPREP00000022126	ENSPREP00000014751	Ion_trans domain-containing protein.	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.	0.524
ENSPREP00000022126	trpa1	ENSPREP00000022126	ENSPREP00000026537	Ion_trans domain-containing protein.	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.	0.744
ENSPREP00000022126	trpm2	ENSPREP00000022126	ENSPREP00000014703	Ion_trans domain-containing protein.	Transient receptor potential cation channel, subfamily M, member 2.	0.926
ENSPREP00000023207	ENSPREP00000022126	ENSPREP00000023207	ENSPREP00000022126	LSDAT_euk domain-containing protein.	Ion_trans domain-containing protein.	0.918
ENSPREP00000023207	LOC103478031	ENSPREP00000023207	ENSPREP00000014751	LSDAT_euk domain-containing protein.	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.	0.524
ENSPREP00000023207	trpa1	ENSPREP00000023207	ENSPREP00000026537	LSDAT_euk domain-containing protein.	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.	0.744
ENSPREP00000023411	ENSPREP00000029973	ENSPREP00000023411	ENSPREP00000029973	WH1 domain-containing protein.	VASP_tetra domain-containing protein.	0.788
ENSPREP00000029973	ENSPREP00000023411	ENSPREP00000029973	ENSPREP00000023411	VASP_tetra domain-containing protein.	WH1 domain-containing protein.	0.788
LOC103464157	SHMT2	ENSPREP00000021436	ENSPREP00000002198	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.597
LOC103464157	tdo2	ENSPREP00000021436	ENSPREP00000014848	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.655
LOC103464157	upb1	ENSPREP00000021436	ENSPREP00000024404	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	Ureidopropionase, beta.	0.650
LOC103467309	AQP4	ENSPREP00000032982	ENSPREP00000006988	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.467
LOC103467309	LOC103467615	ENSPREP00000032982	ENSPREP00000010636	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.489
LOC103467614	AQP4	ENSPREP00000010814	ENSPREP00000006988	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.468
LOC103467614	LOC103467615	ENSPREP00000010814	ENSPREP00000010636	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.488
LOC103467615	LOC103467309	ENSPREP00000010636	ENSPREP00000032982	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.489
LOC103467615	LOC103467614	ENSPREP00000010636	ENSPREP00000010814	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.488