(75 nodes) Regulation of nuclear division network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mad1l1	Mitotic arrest deficient 1 like 1. (719 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	klhl22	Kelch-like family member 22. (673 aa)
	cdk5rap2	Uncharacterized protein. (2228 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	fbxo5	F-box protein 5. (376 aa)
	Tgfa	Transforming growth factor, alpha. (166 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (719 aa)
	ENSPREP00000004304	Cnn_1N domain-containing protein. (68 aa)
	LOC103473479	EGF-like domain-containing protein. (217 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	ENSPREP00000006911	Uncharacterized protein. (216 aa)
	LOC103479019	Fizzy/cell division cycle 20 related 1b. (396 aa)
	Mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (376 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	mad2l1bp	MAD2L1 binding protein. (372 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (620 aa)
	haspin	Si:dkeyp-26a9.2. (1200 aa)
	rcc1	Regulator of chromosome condensation 1. (417 aa)
	edn1	Endothelin 1. (207 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2383 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	LOC103469984	EGF-like domain-containing protein. (176 aa)
	mtbp	MDM2 binding protein. (745 aa)
	zwilch	Zwilch kinetochore protein. (594 aa)
	bora	Bora aurora kinase A activator. (556 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
	cdc27	Cell division cycle 27. (803 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	LOC103470686	Interleukin-1. (247 aa)
	ENSPREP00000020113	CULLIN_2 domain-containing protein; Belongs to the cullin family. (520 aa)
	ENSPREP00000020124	Uncharacterized protein. (171 aa)
	LOC103471497	Aurora kinase B; Belongs to the protein kinase superfamily. (350 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	ENSPREP00000021048	BUB1 N-terminal domain-containing protein. (264 aa)
	ENSPREP00000021545	Uncharacterized protein. (255 aa)
	LOC103479306	Translocated promoter region a, nuclear basket protein. (1861 aa)
	fbxw5	F-box and WD repeat domain containing 5. (626 aa)
	ttk	Ttk protein kinase. (996 aa)
	LOC103479415	SMYLE_N domain-containing protein. (1839 aa)
	lcmt1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (325 aa)
	znf207	Zinc finger protein 207, b. (473 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	LOC103479391	CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
	zw10	Zw10 kinetochore protein. (767 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (470 aa)
	ENSPREP00000027387	PP1-binding domain-containing protein. (588 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	LOC103474461	Cullin 3; Belongs to the cullin family. (767 aa)
	nme6	Nucleoside diphosphate kinase. (182 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	ndc80	NDC80 kinetochore complex component. (642 aa)
	hormad1	HORMA domain containing 1. (372 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	ENSPREP00000030212	Nanos homolog 2; Belongs to the nanos family. (116 aa)
	LOC103482107	Marker of proliferation Ki-67. (1716 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	Rgcc	Regulator of cell cycle. (134 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	wee2	Wee1-like protein kinase. (527 aa)
	FBXO43	F-box protein 43. (591 aa)
	ENSPREP00000030697	Uncharacterized protein. (754 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (414 aa)
	kntc1	Kinetochore associated 1. (2067 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	LOC103476970	Muscle segment homeobox 3. (212 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	Spdl1	Uncharacterized protein. (62 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	ENSPREP00000021048	ENSPREP00000021030	ENSPREP00000021048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.847
Bub1	ENSPREP00000027387	ENSPREP00000021030	ENSPREP00000027387	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	PP1-binding domain-containing protein.	0.651
Bub1	FZR1	ENSPREP00000021030	ENSPREP00000026428	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1a.	0.848
Bub1	LOC103471497	ENSPREP00000021030	ENSPREP00000020685	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.754
Bub1	LOC103479019	ENSPREP00000021030	ENSPREP00000007608	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1b.	0.848
Bub1	anapc11	ENSPREP00000021030	ENSPREP00000004954	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC11 anaphase promoting complex subunit 11 homolog (yeast).	0.872
Bub1	anapc15	ENSPREP00000021030	ENSPREP00000028721	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 15.	0.744
Bub1	anapc5	ENSPREP00000021030	ENSPREP00000030371	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 5.	0.937
Bub1	anapc7	ENSPREP00000021030	ENSPREP00000023863	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 7.	0.845
Bub1	bub1b	ENSPREP00000021030	ENSPREP00000032059	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.986
Bub1	bub3	ENSPREP00000021030	ENSPREP00000010595	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB3 mitotic checkpoint protein.	0.996
Bub1	cdc16	ENSPREP00000021030	ENSPREP00000008226	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 16 homolog (S. cerevisiae).	0.948
Bub1	cdc23	ENSPREP00000021030	ENSPREP00000034182	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CDC23 (cell division cycle 23, yeast, homolog).	0.951
Bub1	cdc27	ENSPREP00000021030	ENSPREP00000018474	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 27.	0.950
Bub1	chek1	ENSPREP00000021030	ENSPREP00000025637	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.694
Bub1	fbxo5	ENSPREP00000021030	ENSPREP00000003225	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box protein 5.	0.425
Bub1	haspin	ENSPREP00000021030	ENSPREP00000012250	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Si:dkeyp-26a9.2.	0.487
Bub1	kntc1	ENSPREP00000021030	ENSPREP00000031243	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Kinetochore associated 1.	0.793
Bub1	mad1l1	ENSPREP00000021030	ENSPREP00000000149	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitotic arrest deficient 1 like 1.	0.992
Bub1	mad2l1	ENSPREP00000021030	ENSPREP00000031986	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	MAD2 mitotic arrest deficient-like 1 (yeast).	0.998