(20 nodes) Hsp90 protein binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	tsc2	TSC complex subunit 2. (1898 aa)
	unc45b	Unc-45 myosin chaperone B. (929 aa)
	LOC103482153	Si:ch211-131k2.3. (173 aa)
	stip1	Stress-induced phosphoprotein 1. (574 aa)
	LOC103458156	AHA1, activator of heat shock protein ATPase homolog 1b. (410 aa)
	ENSPREP00000009737	Uncharacterized protein. (615 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1072 aa)
	Pacrg	PARK2 co-regulated. (235 aa)
	ENSPREP00000010558	Prostaglandin E synthase 3b (cytosolic). (140 aa)
	ppid	Peptidylprolyl isomerase D. (373 aa)
	ttc4	Tetratricopeptide repeat domain 4. (396 aa)
	kpnb1	Karyopherin (importin) beta 1. (876 aa)
	fkbp6	Peptidylprolyl isomerase. (332 aa)
	ahsa1	Aha1_N domain-containing protein. (385 aa)
	ppp5c	Serine/threonine-protein phosphatase. (472 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (783 aa)
	unc45a	Unc-45 myosin chaperone A. (940 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	LOC103467311	Prostaglandin E synthase 3a (cytosolic). (172 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010558	LOC103458156	ENSPREP00000010558	ENSPREP00000008620	Prostaglandin E synthase 3b (cytosolic).	AHA1, activator of heat shock protein ATPase homolog 1b.	0.716
ENSPREP00000010558	ahsa1	ENSPREP00000010558	ENSPREP00000020402	Prostaglandin E synthase 3b (cytosolic).	Aha1_N domain-containing protein.	0.716
ENSPREP00000010558	fkbp6	ENSPREP00000010558	ENSPREP00000019507	Prostaglandin E synthase 3b (cytosolic).	Peptidylprolyl isomerase.	0.578
ENSPREP00000010558	ppid	ENSPREP00000010558	ENSPREP00000011612	Prostaglandin E synthase 3b (cytosolic).	Peptidylprolyl isomerase D.	0.885
ENSPREP00000010558	ppp5c	ENSPREP00000010558	ENSPREP00000027168	Prostaglandin E synthase 3b (cytosolic).	Serine/threonine-protein phosphatase.	0.935
ENSPREP00000010558	stip1	ENSPREP00000010558	ENSPREP00000008322	Prostaglandin E synthase 3b (cytosolic).	Stress-induced phosphoprotein 1.	0.938
ENSPREP00000010558	tsc1	ENSPREP00000010558	ENSPREP00000032075	Prostaglandin E synthase 3b (cytosolic).	TSC complex subunit 1b.	0.870
ENSPREP00000010558	ttc4	ENSPREP00000010558	ENSPREP00000014495	Prostaglandin E synthase 3b (cytosolic).	Tetratricopeptide repeat domain 4.	0.553
LOC103458156	ENSPREP00000010558	ENSPREP00000008620	ENSPREP00000010558	AHA1, activator of heat shock protein ATPase homolog 1b.	Prostaglandin E synthase 3b (cytosolic).	0.716
LOC103458156	LOC103467311	ENSPREP00000008620	ENSPREP00000032865	AHA1, activator of heat shock protein ATPase homolog 1b.	Prostaglandin E synthase 3a (cytosolic).	0.716
LOC103458156	LOC103482153	ENSPREP00000008620	ENSPREP00000006926	AHA1, activator of heat shock protein ATPase homolog 1b.	Si:ch211-131k2.3.	0.691
LOC103458156	ppid	ENSPREP00000008620	ENSPREP00000011612	AHA1, activator of heat shock protein ATPase homolog 1b.	Peptidylprolyl isomerase D.	0.800
LOC103458156	ppp5c	ENSPREP00000008620	ENSPREP00000027168	AHA1, activator of heat shock protein ATPase homolog 1b.	Serine/threonine-protein phosphatase.	0.516
LOC103458156	stip1	ENSPREP00000008620	ENSPREP00000008322	AHA1, activator of heat shock protein ATPase homolog 1b.	Stress-induced phosphoprotein 1.	0.939
LOC103458156	tsc1	ENSPREP00000008620	ENSPREP00000032075	AHA1, activator of heat shock protein ATPase homolog 1b.	TSC complex subunit 1b.	0.783
LOC103458156	ttc4	ENSPREP00000008620	ENSPREP00000014495	AHA1, activator of heat shock protein ATPase homolog 1b.	Tetratricopeptide repeat domain 4.	0.410
LOC103467311	LOC103458156	ENSPREP00000032865	ENSPREP00000008620	Prostaglandin E synthase 3a (cytosolic).	AHA1, activator of heat shock protein ATPase homolog 1b.	0.716
LOC103467311	ahsa1	ENSPREP00000032865	ENSPREP00000020402	Prostaglandin E synthase 3a (cytosolic).	Aha1_N domain-containing protein.	0.716
LOC103467311	fkbp6	ENSPREP00000032865	ENSPREP00000019507	Prostaglandin E synthase 3a (cytosolic).	Peptidylprolyl isomerase.	0.578
LOC103467311	ppid	ENSPREP00000032865	ENSPREP00000011612	Prostaglandin E synthase 3a (cytosolic).	Peptidylprolyl isomerase D.	0.885