(24 nodes) Membrane depolarization network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (558 aa)
	Cav1	Uncharacterized protein. (84 aa)
	LOC103459879	Uncharacterized protein. (436 aa)
	ENSPREP00000011080	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (465 aa)
	ENSPREP00000011113	Uncharacterized protein. (437 aa)
	ENSPREP00000011136	Uncharacterized protein. (214 aa)
	Scn1a	Uncharacterized protein. (624 aa)
	ENSPREP00000011241	Uncharacterized protein. (277 aa)
	chrna9	Cholinergic receptor, nicotinic, alpha 9. (446 aa)
	scn1b	Sodium channel, voltage-gated, type I, beta b. (223 aa)
	ENSPREP00000014273	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (408 aa)
	ENSPREP00000014343	Uncharacterized protein. (415 aa)
	ENSPREP00000014422	Ion_trans domain-containing protein. (231 aa)
	LOC103474955	Uncharacterized protein. (487 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	LOC103474271	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2002 aa)
	LOC103465359	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1964 aa)
	ENSPREP00000024427	IGv domain-containing protein. (354 aa)
	LOC103474422	Sodium channel, voltage-gated, type II, beta. (225 aa)
	LOC103474423	Sodium channel, voltage-gated, type IV, beta a. (233 aa)
	LOC103478857	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1732 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (216 aa)
	LOC103467306	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1756 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000011080	ENSPREP00000011113	ENSPREP00000011080	ENSPREP00000011113	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.947
ENSPREP00000011080	ENSPREP00000011136	ENSPREP00000011080	ENSPREP00000011136	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.966
ENSPREP00000011080	ENSPREP00000011241	ENSPREP00000011080	ENSPREP00000011241	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.950
ENSPREP00000011080	ENSPREP00000014343	ENSPREP00000011080	ENSPREP00000014343	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.948
ENSPREP00000011080	ENSPREP00000014422	ENSPREP00000011080	ENSPREP00000014422	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ion_trans domain-containing protein.	0.916
ENSPREP00000011080	ENSPREP00000024427	ENSPREP00000011080	ENSPREP00000024427	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	IGv domain-containing protein.	0.689
ENSPREP00000011080	LOC103474422	ENSPREP00000011080	ENSPREP00000025599	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type II, beta.	0.791
ENSPREP00000011080	LOC103474423	ENSPREP00000011080	ENSPREP00000025615	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type IV, beta a.	0.508
ENSPREP00000011080	Scn1a	ENSPREP00000011080	ENSPREP00000011224	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.948
ENSPREP00000011080	scn1b	ENSPREP00000011080	ENSPREP00000013607	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type I, beta b.	0.689
ENSPREP00000011080	scn3b	ENSPREP00000011080	ENSPREP00000032918	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type III, beta.	0.592
ENSPREP00000011113	ENSPREP00000011080	ENSPREP00000011113	ENSPREP00000011080	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.947
ENSPREP00000011113	ENSPREP00000011241	ENSPREP00000011113	ENSPREP00000011241	Uncharacterized protein.	Uncharacterized protein.	0.414
ENSPREP00000011113	ENSPREP00000014273	ENSPREP00000011113	ENSPREP00000014273	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.947
ENSPREP00000011113	ENSPREP00000014422	ENSPREP00000011113	ENSPREP00000014422	Uncharacterized protein.	Ion_trans domain-containing protein.	0.899
ENSPREP00000011113	ENSPREP00000024427	ENSPREP00000011113	ENSPREP00000024427	Uncharacterized protein.	IGv domain-containing protein.	0.689
ENSPREP00000011113	LOC103474422	ENSPREP00000011113	ENSPREP00000025599	Uncharacterized protein.	Sodium channel, voltage-gated, type II, beta.	0.791
ENSPREP00000011113	LOC103474423	ENSPREP00000011113	ENSPREP00000025615	Uncharacterized protein.	Sodium channel, voltage-gated, type IV, beta a.	0.508
ENSPREP00000011113	Scn1a	ENSPREP00000011113	ENSPREP00000011224	Uncharacterized protein.	Uncharacterized protein.	0.915
ENSPREP00000011113	scn1b	ENSPREP00000011113	ENSPREP00000013607	Uncharacterized protein.	Sodium channel, voltage-gated, type I, beta b.	0.689