(104 nodes) Digestive system development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103476345	Kruppel-like factor 5 like. (390 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	pkd1	Polycystic kidney disease 1a. (4592 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	LOC103459837	Fork-head domain-containing protein. (201 aa)
	mixl1	Mix paired-like homeobox. (305 aa)
	LOC103473440	Notch receptor 1a. (2478 aa)
	ENSPREP00000002748	Myogenic factor. (237 aa)
	LOC103478941	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (467 aa)
	LOC103459074	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	epg5	Ectopic P-granules autophagy protein 5 homolog (C. elegans). (2575 aa)
	hhex	Homeobox domain-containing protein. (296 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (631 aa)
	LOC103466325	G protein-coupled receptor 22b. (439 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	clmp	Uncharacterized protein. (385 aa)
	LOC103466925	GATA binding protein 5. (372 aa)
	utp25	UTP25 small subunit processor component. (748 aa)
	ENSPREP00000008873	PR/SET domain 1. (783 aa)
	LOC103479222	Kruppel-like factor 5b. (437 aa)
	ENSPREP00000009398	Homeobox domain-containing protein. (161 aa)
	notch1	Notch receptor 1b. (2491 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (200 aa)
	IKZF5	IKAROS family zinc finger 5. (422 aa)
	Wtip	WT1 interacting protein. (624 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	tbx10	Uncharacterized protein. (280 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa)
	isl2	ISL LIM homeobox 2a. (359 aa)
	LOC103480354	Vang-like protein. (525 aa)
	ruvbl2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (770 aa)
	ENSPREP00000013954	Uncharacterized protein. (326 aa)
	LOC103477293	Fibroblast growth factor receptor. (676 aa)
	ENSPREP00000014132	Uncharacterized protein. (138 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (361 aa)
	Foxf2	Forkhead box F2b. (355 aa)
	LOC103479651	Forkhead box F2a. (351 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (506 aa)
	pitx2	Homeobox protein. (312 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
	tcf21	Transcription factor 21. (175 aa)
	klf5	Progesterone immunomodulatory binding factor 1. (566 aa)
	LOC103473100	PR domain containing 1b, with ZNF domain. (758 aa)
	LOC103476747	IKAROS family zinc finger 5. (439 aa)
	LOC103478362	Cordon-bleu WH2 repeat protein. (1443 aa)
	ptf1a	Pancreas associated transcription factor 1a. (267 aa)
	LOC103473122	Histone domain-containing protein. (169 aa)
	il6st	Uncharacterized protein. (896 aa)
	LOC103471920	Anterior gradient 2. (159 aa)
	gpr22	G_PROTEIN_RECEP_F1_2 domain-containing protein. (428 aa)
	LOC103470081	Hcy-binding domain-containing protein. (435 aa)
	LOC103470080	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (397 aa)
	clg21h6orf58	Liver-enriched gene 1, tandem duplicate 1. (357 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	nkx3-2	NK3 homeobox 2. (265 aa)
	ENSPREP00000020767	Uncharacterized protein. (110 aa)
	LOC103473783	Nipped-B protein. (2642 aa)
	wdr55	WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (413 aa)
	LOC103471993	T-box transcription factor Ta. (421 aa)
	yap1	Yes-associated protein 1. (433 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	ENSPREP00000022685	Abelson helper integration site 1. (907 aa)
	Mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (526 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (574 aa)
	LOC103469637	ISL LIM homeobox 1. (373 aa)
	gata6	GATA binding protein 6. (454 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (994 aa)
	sav1	Salvador family WW domain containing protein 1. (383 aa)
	myocd	SAP domain-containing protein. (936 aa)
	Msc	Musculin (activated B-cell factor-1). (148 aa)
	sec31a	SEC31 homolog A, COPII coat complex component. (1341 aa)
	tbx1	T-box transcription factor 1. (498 aa)
	invs	Inversin. (942 aa)
	ENSPREP00000028065	Forkhead box A3. (426 aa)
	LOC103473309	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
	ENSPREP00000028482	Uncharacterized protein. (587 aa)
	ENSPREP00000028578	Ion_trans domain-containing protein; Belongs to the potassium channel family. (424 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (876 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	nipbl	Nipped-B protein. (2355 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	ENSPREP00000028885	Forkhead box L1. (212 aa)
	ENSPREP00000029052	NK3 homeobox 3. (156 aa)
	nkx2-3	NK2 homeobox 3. (349 aa)
	igf2	IlGF domain-containing protein. (223 aa)
	gata4	GATA binding protein 4. (396 aa)
	med24	Mediator complex subunit 24. (989 aa)
	tbx20	T-box transcription factor 20. (440 aa)
	LOC103470093	Homeobox domain-containing protein. (363 aa)
	wdpcp	WD repeat containing planar cell polarity effector. (512 aa)
	vps52	VPS52 subunit of GARP complex. (574 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2620 aa)
	LOC103470946	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (947 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	myf5	Myogenic factor. (240 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (670 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000014132	LOC103473122	ENSPREP00000014132	ENSPREP00000018114	Uncharacterized protein.	Histone domain-containing protein.	0.578
ENSPREP00000014132	suv39h1	ENSPREP00000014132	ENSPREP00000012183	Uncharacterized protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.433
ENSPREP00000020767	LOC103473783	ENSPREP00000020767	ENSPREP00000020900	Uncharacterized protein.	Nipped-B protein.	0.899
ENSPREP00000022685	invs	ENSPREP00000022685	ENSPREP00000027577	Abelson helper integration site 1.	Inversin.	0.586
ENSPREP00000028065	LOC103466925	ENSPREP00000028065	ENSPREP00000006733	Forkhead box A3.	GATA binding protein 5.	0.556
ENSPREP00000028065	gata4	ENSPREP00000028065	ENSPREP00000029877	Forkhead box A3.	GATA binding protein 4.	0.556
ENSPREP00000028065	gata6	ENSPREP00000028065	ENSPREP00000025542	Forkhead box A3.	GATA binding protein 6.	0.619
ENSPREP00000028065	hhex	ENSPREP00000028065	ENSPREP00000004748	Forkhead box A3.	Homeobox domain-containing protein.	0.579
EZH1	LOC103473122	ENSPREP00000013900	ENSPREP00000018114	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone domain-containing protein.	0.578
EZH1	suv39h1	ENSPREP00000013900	ENSPREP00000012183	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.433
Foxf2	LOC103466925	ENSPREP00000014755	ENSPREP00000006733	Forkhead box F2b.	GATA binding protein 5.	0.411
Foxf2	gata4	ENSPREP00000014755	ENSPREP00000029877	Forkhead box F2b.	GATA binding protein 4.	0.411
Foxf2	gata6	ENSPREP00000014755	ENSPREP00000025542	Forkhead box F2b.	GATA binding protein 6.	0.511
Foxf2	nkx3-2	ENSPREP00000014755	ENSPREP00000020528	Forkhead box F2b.	NK3 homeobox 2.	0.435
LOC103459074	LOC103470946	ENSPREP00000002951	ENSPREP00000032490	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC103459074	LOC103478941	ENSPREP00000002951	ENSPREP00000002847	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC103466925	ENSPREP00000028065	ENSPREP00000006733	ENSPREP00000028065	GATA binding protein 5.	Forkhead box A3.	0.556
LOC103466925	Foxf2	ENSPREP00000006733	ENSPREP00000014755	GATA binding protein 5.	Forkhead box F2b.	0.411
LOC103466925	LOC103479651	ENSPREP00000006733	ENSPREP00000014946	GATA binding protein 5.	Forkhead box F2a.	0.411
LOC103466925	hand2	ENSPREP00000006733	ENSPREP00000032725	GATA binding protein 5.	Heart and neural crest derivatives expressed 2.	0.637