(31 nodes) Convergent extension involved in gastrulation network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	mcu	Mitochondrial calcium uniporter. (376 aa)
	def6	DEF6 guanine nucleotide exchange factor a. (619 aa)
	LOC103457816	Uncharacterized protein. (606 aa)
	lrrc1	Leucine rich repeat containing 1. (522 aa)
	ENSPREP00000031125	Leucine rich repeat containing 6. (397 aa)
	LOC103458010	Tyrosine-protein kinase. (537 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (742 aa)
	adgra3	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1350 aa)
	invs	Inversin. (942 aa)
	LOC103474427	Dynein assembly factor 1, axonemal. (582 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	LOC103479892	Tyrosine-protein kinase. (473 aa)
	tmem237	Transmembrane protein 237b. (378 aa)
	LOC103471469	Transmembrane protein 216. (205 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	LOC103460196	Transmembrane protein 237a. (357 aa)
	chrd	Chordin; Belongs to the chordin family. (949 aa)
	LOC103480354	Vang-like protein. (525 aa)
	tdp2	Tyrosyl-DNA phosphodiesterase 2b. (359 aa)
	YES1	Tyrosine-protein kinase. (454 aa)
	LOC103458742	Tyrosine-protein kinase. (537 aa)
	scrib	Scribble planar cell polarity protein. (1718 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	gdf3	Growth differentiation factor 3. (402 aa)
	LOC103471035	Mothers against decapentaplegic homolog. (475 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (336 aa)
	desi2	Desumoylating isopeptidase 2. (209 aa)
	ofd1	OFD1 centriole and centriolar satellite protein. (978 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000031125	LOC103474427	ENSPREP00000031125	ENSPREP00000026082	Leucine rich repeat containing 6.	Dynein assembly factor 1, axonemal.	0.534
LOC103458010	LOC103479892	ENSPREP00000030555	ENSPREP00000022831	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.438
LOC103458010	YES1	ENSPREP00000030555	ENSPREP00000011214	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.434
LOC103458742	LOC103479892	ENSPREP00000009827	ENSPREP00000022831	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.941
LOC103458742	YES1	ENSPREP00000009827	ENSPREP00000011214	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.941
LOC103459284	LOC103467447	ENSPREP00000006858	ENSPREP00000028159	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103459284	LOC103480354	ENSPREP00000006858	ENSPREP00000012627	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Vang-like protein.	0.437
LOC103459284	VANGL2	ENSPREP00000006858	ENSPREP00000001301	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	VANGL planar cell polarity protein 2.	0.437
LOC103460196	LOC103471469	ENSPREP00000017125	ENSPREP00000021714	Transmembrane protein 237a.	Transmembrane protein 216.	0.407
LOC103467447	LOC103459284	ENSPREP00000028159	ENSPREP00000006858	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103467447	LOC103480354	ENSPREP00000028159	ENSPREP00000012627	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Vang-like protein.	0.437
LOC103467447	VANGL2	ENSPREP00000028159	ENSPREP00000001301	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	VANGL planar cell polarity protein 2.	0.437
LOC103471035	bmp2	ENSPREP00000005305	ENSPREP00000023949	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 2b.	0.662
LOC103471035	chrd	ENSPREP00000005305	ENSPREP00000014581	Mothers against decapentaplegic homolog.	Chordin; Belongs to the chordin family.	0.482
LOC103471469	LOC103460196	ENSPREP00000021714	ENSPREP00000017125	Transmembrane protein 216.	Transmembrane protein 237a.	0.407
LOC103471469	ofd1	ENSPREP00000021714	ENSPREP00000002437	Transmembrane protein 216.	OFD1 centriole and centriolar satellite protein.	0.549
LOC103471469	tmem237	ENSPREP00000021714	ENSPREP00000022256	Transmembrane protein 216.	Transmembrane protein 237b.	0.407
LOC103474427	ENSPREP00000031125	ENSPREP00000026082	ENSPREP00000031125	Dynein assembly factor 1, axonemal.	Leucine rich repeat containing 6.	0.534
LOC103479892	LOC103458010	ENSPREP00000022831	ENSPREP00000030555	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.438
LOC103479892	LOC103458742	ENSPREP00000022831	ENSPREP00000009827	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.941