(55 nodes) Heart contraction network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SGCZ	Sarcoglycan zeta. (287 aa)
	MYL2	Myosin light chain 2. (169 aa)
	smyd2	Uncharacterized protein. (499 aa)
	Rangrf	RAN guanine nucleotide release factor. (189 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (187 aa)
	LOC103465645	Troponin I2, fast skeletal type. (171 aa)
	ENSPREP00000002982	Troponin I2, fast skeletal type. (161 aa)
	LOC103465646	Troponin I2, fast skeletal type. (171 aa)
	LOC103468062	Troponin C type 1b (slow). (161 aa)
	ENSPREP00000004310	Uncharacterized protein. (69 aa)
	LOC103459244	Uncharacterized protein. (205 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (631 aa)
	sgcg	Sarcoglycan, gamma. (306 aa)
	strip1	Striatin interacting protein 1. (816 aa)
	lrrc39	Leucine rich repeat containing 39. (378 aa)
	ENSPREP00000009754	DND microRNA-mediated repression inhibitor 1. (367 aa)
	myl3	Myosin, light chain 13. (92 aa)
	LOC103468695	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	TNNC1	Troponin C type 1a (slow). (163 aa)
	LOC103465819	Troponin I4a. (177 aa)
	LOC103465820	Troponin I4b, tandem duplicate 2. (182 aa)
	LOC103465821	Uncharacterized protein. (183 aa)
	LOC103465822	Troponin I4b, tandem duplicate 2. (178 aa)
	scn1b	Sodium channel, voltage-gated, type I, beta b. (223 aa)
	myl7	Myosin, light chain 7, regulatory. (175 aa)
	Kcne4	Potassium voltage-gated channel, Isk-related family, member 4. (185 aa)
	ccm2	CCM2 scaffold protein. (466 aa)
	tcap	Titin-cap (telethonin). (187 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	slc2a12	Solute carrier family 2 member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
	LOC103464710	Troponin I type 1b (skeletal, slow). (170 aa)
	washc5	WASH complex subunit 5. (1159 aa)
	krit1	KRIT1 ankyrin repeat containing. (739 aa)
	sgcd	Sarcoglycan, delta (dystrophin-associated glycoprotein). (379 aa)
	nup155	Nucleoporin 155. (1373 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
	Vegfb	Vascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (94 aa)
	LOC103469530	Myosin, light chain 2a, regulatory, cardiac, slow. (168 aa)
	ENSPREP00000024223	Uncharacterized protein. (147 aa)
	ENSPREP00000024260	Uncharacterized protein. (152 aa)
	ENSPREP00000024427	IGv domain-containing protein. (354 aa)
	LOC103480654	Uncharacterized protein. (311 aa)
	LOC103474422	Sodium channel, voltage-gated, type II, beta. (225 aa)
	LOC103474423	Sodium channel, voltage-gated, type IV, beta a. (233 aa)
	alpk2	Uncharacterized protein. (1369 aa)
	TNNI2	Troponin I type 2b (skeletal, fast), tandem duplicate 1. (174 aa)
	ENSPREP00000028578	Ion_trans domain-containing protein; Belongs to the potassium channel family. (424 aa)
	csrp3	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	tnni1	Troponin I type 1a (skeletal, slow). (205 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (216 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (671 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002982	ENSPREP00000024260	ENSPREP00000002982	ENSPREP00000024260	Troponin I2, fast skeletal type.	Uncharacterized protein.	0.590
ENSPREP00000002982	LOC103464710	ENSPREP00000002982	ENSPREP00000018100	Troponin I2, fast skeletal type.	Troponin I type 1b (skeletal, slow).	0.642
ENSPREP00000002982	LOC103465819	ENSPREP00000002982	ENSPREP00000012191	Troponin I2, fast skeletal type.	Troponin I4a.	0.593
ENSPREP00000002982	LOC103465820	ENSPREP00000002982	ENSPREP00000012264	Troponin I2, fast skeletal type.	Troponin I4b, tandem duplicate 2.	0.589
ENSPREP00000002982	LOC103465821	ENSPREP00000002982	ENSPREP00000012478	Troponin I2, fast skeletal type.	Uncharacterized protein.	0.588
ENSPREP00000002982	LOC103465822	ENSPREP00000002982	ENSPREP00000012522	Troponin I2, fast skeletal type.	Troponin I4b, tandem duplicate 2.	0.598
ENSPREP00000002982	LOC103468062	ENSPREP00000002982	ENSPREP00000003392	Troponin I2, fast skeletal type.	Troponin C type 1b (slow).	0.792
ENSPREP00000002982	LOC103469530	ENSPREP00000002982	ENSPREP00000023651	Troponin I2, fast skeletal type.	Myosin, light chain 2a, regulatory, cardiac, slow.	0.602
ENSPREP00000002982	MYL2	ENSPREP00000002982	ENSPREP00000000746	Troponin I2, fast skeletal type.	Myosin light chain 2.	0.602
ENSPREP00000002982	TNNC1	ENSPREP00000002982	ENSPREP00000011929	Troponin I2, fast skeletal type.	Troponin C type 1a (slow).	0.792
ENSPREP00000002982	TNNI2	ENSPREP00000002982	ENSPREP00000027370	Troponin I2, fast skeletal type.	Troponin I type 2b (skeletal, fast), tandem duplicate 1.	0.409
ENSPREP00000002982	myl3	ENSPREP00000002982	ENSPREP00000010910	Troponin I2, fast skeletal type.	Myosin, light chain 13.	0.590
ENSPREP00000002982	myl7	ENSPREP00000002982	ENSPREP00000015234	Troponin I2, fast skeletal type.	Myosin, light chain 7, regulatory.	0.515
ENSPREP00000002982	tnni1	ENSPREP00000002982	ENSPREP00000029394	Troponin I2, fast skeletal type.	Troponin I type 1a (skeletal, slow).	0.643
ENSPREP00000004310	ENSPREP00000024260	ENSPREP00000004310	ENSPREP00000024260	Uncharacterized protein.	Uncharacterized protein.	0.510
ENSPREP00000004310	LOC103465819	ENSPREP00000004310	ENSPREP00000012191	Uncharacterized protein.	Troponin I4a.	0.400
ENSPREP00000004310	LOC103468062	ENSPREP00000004310	ENSPREP00000003392	Uncharacterized protein.	Troponin C type 1b (slow).	0.652
ENSPREP00000004310	LOC103469530	ENSPREP00000004310	ENSPREP00000023651	Uncharacterized protein.	Myosin, light chain 2a, regulatory, cardiac, slow.	0.479
ENSPREP00000004310	MYL2	ENSPREP00000004310	ENSPREP00000000746	Uncharacterized protein.	Myosin light chain 2.	0.479
ENSPREP00000004310	TNNC1	ENSPREP00000004310	ENSPREP00000011929	Uncharacterized protein.	Troponin C type 1a (slow).	0.652