(14 nodes) Embryonic retina morphogenesis in camera-type eye network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gdf5	Growth differentiation factor 5. (484 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	LOC103463647	Forkhead box Q2. (289 aa)
	ENSPREP00000013704	Uncharacterized protein. (155 aa)
	LOC103460864	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	FOXC1	Forkhead box C1. (471 aa)
	ENSPREP00000014932	Forkhead box C1. (275 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	LOC103478252	Growth differentiation factor 6a. (418 aa)
	lhx1	LIM homeobox 1a. (374 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000013704	LOC103460864	ENSPREP00000013704	ENSPREP00000013760	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.854
LOC103460864	ENSPREP00000013704	ENSPREP00000013760	ENSPREP00000013704	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.854
LOC103460864	mpp5	ENSPREP00000013760	ENSPREP00000012779	Uncharacterized protein; Belongs to the MAGUK family.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.902
LOC103476521	fgf3	ENSPREP00000029747	ENSPREP00000002583	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.795
fgf3	LOC103476521	ENSPREP00000002583	ENSPREP00000029747	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.795
mpp5	LOC103460864	ENSPREP00000012779	ENSPREP00000013760	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.902