(19 nodes) Wnt signaling pathway, planar cell polarity pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSPREP00000001242	DIX domain-containing protein. (55 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	ENSPREP00000001400	Uncharacterized protein. (444 aa)
	dvl1	Dishevelled segment polarity protein 1a. (653 aa)
	VANGL1	Vang-like protein. (527 aa)
	LOC103480354	Vang-like protein. (525 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC103467575	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	LOC103465913	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	dvl2	Dishevelled segment polarity protein 2. (763 aa)
	LOC103479347	Dishevelled segment polarity protein 3a. (457 aa)
	ENSPREP00000020826	DIX domain-containing protein. (54 aa)
	ryk	Receptor like tyrosine kinase. (632 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	adgra3	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1350 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001242	ENSPREP00000020826	ENSPREP00000001242	ENSPREP00000020826	DIX domain-containing protein.	DIX domain-containing protein.	0.901
ENSPREP00000001242	LOC103474475	ENSPREP00000001242	ENSPREP00000028750	DIX domain-containing protein.	Uncharacterized protein.	0.441
ENSPREP00000001242	LOC103480354	ENSPREP00000001242	ENSPREP00000012627	DIX domain-containing protein.	Vang-like protein.	0.956
ENSPREP00000001242	VANGL1	ENSPREP00000001242	ENSPREP00000009745	DIX domain-containing protein.	Vang-like protein.	0.956
ENSPREP00000001242	VANGL2	ENSPREP00000001242	ENSPREP00000001301	DIX domain-containing protein.	VANGL planar cell polarity protein 2.	0.956
ENSPREP00000001242	dvl2	ENSPREP00000001242	ENSPREP00000018043	DIX domain-containing protein.	Dishevelled segment polarity protein 2.	0.910
ENSPREP00000001242	sfrp2	ENSPREP00000001242	ENSPREP00000000067	DIX domain-containing protein.	Secreted frizzled-related protein 2.	0.441
ENSPREP00000001400	LOC103474475	ENSPREP00000001400	ENSPREP00000028750	Uncharacterized protein.	Uncharacterized protein.	0.441
ENSPREP00000001400	LOC103480354	ENSPREP00000001400	ENSPREP00000012627	Uncharacterized protein.	Vang-like protein.	0.585
ENSPREP00000001400	VANGL1	ENSPREP00000001400	ENSPREP00000009745	Uncharacterized protein.	Vang-like protein.	0.585
ENSPREP00000001400	VANGL2	ENSPREP00000001400	ENSPREP00000001301	Uncharacterized protein.	VANGL planar cell polarity protein 2.	0.585
ENSPREP00000001400	sfrp2	ENSPREP00000001400	ENSPREP00000000067	Uncharacterized protein.	Secreted frizzled-related protein 2.	0.441
ENSPREP00000020826	ENSPREP00000001242	ENSPREP00000020826	ENSPREP00000001242	DIX domain-containing protein.	DIX domain-containing protein.	0.901
ENSPREP00000020826	LOC103474475	ENSPREP00000020826	ENSPREP00000028750	DIX domain-containing protein.	Uncharacterized protein.	0.441
ENSPREP00000020826	LOC103480354	ENSPREP00000020826	ENSPREP00000012627	DIX domain-containing protein.	Vang-like protein.	0.956
ENSPREP00000020826	VANGL1	ENSPREP00000020826	ENSPREP00000009745	DIX domain-containing protein.	Vang-like protein.	0.956
ENSPREP00000020826	VANGL2	ENSPREP00000020826	ENSPREP00000001301	DIX domain-containing protein.	VANGL planar cell polarity protein 2.	0.956
ENSPREP00000020826	dvl2	ENSPREP00000020826	ENSPREP00000018043	DIX domain-containing protein.	Dishevelled segment polarity protein 2.	0.910
ENSPREP00000020826	sfrp2	ENSPREP00000020826	ENSPREP00000000067	DIX domain-containing protein.	Secreted frizzled-related protein 2.	0.441
LOC103465913	LOC103474475	ENSPREP00000017114	ENSPREP00000028750	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.810