(16 nodes) Dendritic spine development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC42	Cell division cycle 42. (191 aa)
	LOC103479062	Eph receptor B3a. (959 aa)
	ephb3	Receptor protein-tyrosine kinase. (1013 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (834 aa)
	Shank1	SAM domain-containing protein. (1628 aa)
	LOC103458433	Non-specific serine/threonine protein kinase. (507 aa)
	LOC103466031	SH3 and multiple ankyrin repeat domains 3a. (1984 aa)
	LOC103463007	SH3 and multiple ankyrin repeat domains 2a. (1709 aa)
	pak1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	LOC103481054	Uncharacterized protein. (2065 aa)
	LOC103465423	Cell division cycle 42. (191 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (542 aa)
	dock10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2188 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	srgap2	SLIT-ROBO Rho GTPase activating protein 2. (1124 aa)
	PAK3	Non-specific serine/threonine protein kinase. (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	LOC103458433	ENSPREP00000005959	ENSPREP00000016553	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.982
CDC42	PAK3	ENSPREP00000005959	ENSPREP00000034117	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.988
CDC42	dock10	ENSPREP00000005959	ENSPREP00000033413	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.897
CDC42	pak1	ENSPREP00000005959	ENSPREP00000025701	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.891
CDC42	pak2	ENSPREP00000005959	ENSPREP00000030798	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.982
CDC42	srgap2	ENSPREP00000005959	ENSPREP00000005273	Cell division cycle 42.	SLIT-ROBO Rho GTPase activating protein 2.	0.449
LOC103458433	CDC42	ENSPREP00000016553	ENSPREP00000005959	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.982
LOC103458433	LOC103465423	ENSPREP00000016553	ENSPREP00000026666	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.835
LOC103458433	PAK3	ENSPREP00000016553	ENSPREP00000034117	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.650
LOC103458433	pak1	ENSPREP00000016553	ENSPREP00000025701	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.650
LOC103458433	pak2	ENSPREP00000016553	ENSPREP00000030798	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.901
LOC103465423	LOC103458433	ENSPREP00000026666	ENSPREP00000016553	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.835
LOC103465423	PAK3	ENSPREP00000026666	ENSPREP00000034117	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.891
LOC103465423	dock10	ENSPREP00000026666	ENSPREP00000033413	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.897
LOC103465423	pak1	ENSPREP00000026666	ENSPREP00000025701	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.891
LOC103465423	pak2	ENSPREP00000026666	ENSPREP00000030798	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.835
LOC103465423	srgap2	ENSPREP00000026666	ENSPREP00000005273	Cell division cycle 42.	SLIT-ROBO Rho GTPase activating protein 2.	0.449
PAK3	CDC42	ENSPREP00000034117	ENSPREP00000005959	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.988
PAK3	LOC103458433	ENSPREP00000034117	ENSPREP00000016553	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.650
PAK3	LOC103465423	ENSPREP00000034117	ENSPREP00000026666	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.891