(37 nodes) Negative regulation of small molecule metabolic process network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473017	Apolipoprotein Ea. (251 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
	LOC103466252	Dickkopf WNT signaling pathway inhibitor 3b. (257 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103464595	Translocator protein. (147 aa)
	LOC103464594	Translocator protein. (161 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	LOC103464914	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa)
	sirt1	Sirtuin 1. (677 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	LOC103476176	Nuclear protein 1a. (76 aa)
	rd3	Retinal degeneration 3, GUCY2D regulator. (215 aa)
	flcn	Folliculin. (554 aa)
	slc27a4	Solute carrier family 27 member 4. (671 aa)
	SNAI2	Snail family transcriptional repressor 2. (272 aa)
	LOC103476093	PDZ domain containing 3b. (491 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (667 aa)
	LOC103480533	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
	lepr	Uncharacterized protein. (1121 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (765 aa)
	ENSPREP00000019557	ATCAY kinesin light chain interacting caytaxin b. (308 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1888 aa)
	ENSPREP00000021560	Uncharacterized protein. (471 aa)
	LOC103464789	Tribbles pseudokinase 3. (351 aa)
	plek	Pleckstrin. (351 aa)
	acmsd	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	LOC103464093	ATCAY kinesin light chain interacting caytaxin a. (370 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (542 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	etfbkmt	Electron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
	fam3a	Family with sequence similarity 3 member A. (225 aa)
	brca1	Uncharacterized protein. (1344 aa)
	LOC103459301	TP53 induced glycolysis regulatory phosphatase b. (247 aa)
	LOC103462479	Dickkopf WNT signaling pathway inhibitor 3a. (275 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000019557	LOC103464914	ENSPREP00000019557	ENSPREP00000003380	ATCAY kinesin light chain interacting caytaxin b.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.437
ENSPREP00000019557	LOC103468460	ENSPREP00000019557	ENSPREP00000026558	ATCAY kinesin light chain interacting caytaxin b.	E1A binding protein p300 b.	0.452
ENSPREP00000019557	LOC103480533	ENSPREP00000019557	ENSPREP00000015889	ATCAY kinesin light chain interacting caytaxin b.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.437
ENSPREP00000019557	LOC103482005	ENSPREP00000019557	ENSPREP00000030842	ATCAY kinesin light chain interacting caytaxin b.	E1A binding protein p300 a.	0.452
LOC103464914	ENSPREP00000019557	ENSPREP00000003380	ENSPREP00000019557	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	ATCAY kinesin light chain interacting caytaxin b.	0.437
LOC103464914	LOC103480533	ENSPREP00000003380	ENSPREP00000015889	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.902
LOC103468460	ENSPREP00000019557	ENSPREP00000026558	ENSPREP00000019557	E1A binding protein p300 b.	ATCAY kinesin light chain interacting caytaxin b.	0.452
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	brca1	ENSPREP00000026558	ENSPREP00000033076	E1A binding protein p300 b.	Uncharacterized protein.	0.727
LOC103468460	parp1	ENSPREP00000026558	ENSPREP00000001596	E1A binding protein p300 b.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.513
LOC103468460	prmt3	ENSPREP00000026558	ENSPREP00000029341	E1A binding protein p300 b.	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.488
LOC103468460	sirt1	ENSPREP00000026558	ENSPREP00000003960	E1A binding protein p300 b.	Sirtuin 1.	0.587
LOC103479463	sirt1	ENSPREP00000026036	ENSPREP00000003960	Sirtuin 6.	Sirtuin 1.	0.879
LOC103479463	sirt4	ENSPREP00000026036	ENSPREP00000003147	Sirtuin 6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.703
LOC103480533	ENSPREP00000019557	ENSPREP00000015889	ENSPREP00000019557	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	ATCAY kinesin light chain interacting caytaxin b.	0.437
LOC103480533	LOC103464914	ENSPREP00000015889	ENSPREP00000003380	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.902
LOC103482005	ENSPREP00000019557	ENSPREP00000030842	ENSPREP00000019557	E1A binding protein p300 a.	ATCAY kinesin light chain interacting caytaxin b.	0.452
LOC103482005	LOC103468460	ENSPREP00000030842	ENSPREP00000026558	E1A binding protein p300 a.	E1A binding protein p300 b.	0.902
LOC103482005	brca1	ENSPREP00000030842	ENSPREP00000033076	E1A binding protein p300 a.	Uncharacterized protein.	0.727
LOC103482005	parp1	ENSPREP00000030842	ENSPREP00000001596	E1A binding protein p300 a.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.513