(19 nodes) Positive regulation of pattern recognition receptor signaling pathway network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (888 aa)
	Pum2	Uncharacterized protein. (121 aa)
	slc15a4	Solute carrier family 15 member 4. (576 aa)
	LOC103462573	Cytochrome b-245, alpha polypeptide. (126 aa)
	Cav1	Uncharacterized protein. (84 aa)
	ENSPREP00000006991	Uncharacterized protein. (331 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	pum1	Pumilio RNA-binding family member 1. (1163 aa)
	slc46a2	Solute carrier family 46 member 2. (516 aa)
	pum2	Pumilio RNA-binding family member 2. (986 aa)
	CXorf21	Chromosome X open reading frame 21. (324 aa)
	LOC103465116	Ninjurin 1. (142 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	ENSPREP00000014253	Uncharacterized protein. (149 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	ifi35	Interferon-induced protein 35. (384 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1028 aa)
	ENSPREP00000024153	Uncharacterized protein. (676 aa)
	ENSPREP00000025343	Uncharacterized protein. (208 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXorf21	slc15a4	ENSPREP00000011329	ENSPREP00000002872	Chromosome X open reading frame 21.	Solute carrier family 15 member 4.	0.445
ENSPREP00000024153	tirap	ENSPREP00000024153	ENSPREP00000007146	Uncharacterized protein.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.575
Pum2	pum2	ENSPREP00000010189	ENSPREP00000010176	Uncharacterized protein.	Pumilio RNA-binding family member 2.	0.899
TLR5	tirap	ENSPREP00000029068	ENSPREP00000007146	Toll like receptor 5; Belongs to the Toll-like receptor family.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.575
dhx58	ifi35	ENSPREP00000015488	ENSPREP00000016964	DEXH (Asp-Glu-X-His) box polypeptide 58.	Interferon-induced protein 35.	0.680
ifi35	dhx58	ENSPREP00000016964	ENSPREP00000015488	Interferon-induced protein 35.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.680
pum2	Pum2	ENSPREP00000010176	ENSPREP00000010189	Pumilio RNA-binding family member 2.	Uncharacterized protein.	0.899
slc15a4	CXorf21	ENSPREP00000002872	ENSPREP00000011329	Solute carrier family 15 member 4.	Chromosome X open reading frame 21.	0.445
tirap	ENSPREP00000024153	ENSPREP00000007146	ENSPREP00000024153	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	Uncharacterized protein.	0.575
tirap	TLR5	ENSPREP00000007146	ENSPREP00000029068	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.575