(11 nodes) Kynurenine metabolic process network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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protein homology

Your Input:
	kyat3	Kynurenine aminotransferase 3. (459 aa)
	kynu	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (463 aa)
	kyat1	Kynurenine aminotransferase 1. (459 aa)
	got2	Aspartate aminotransferase. (393 aa)
	LOC103476765	Uncharacterized protein. (409 aa)
	aldh8a1	Aldehyde dehydrogenase 8 family, member A1; Belongs to the aldehyde dehydrogenase family. (490 aa)
	tdo2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (403 aa)
	LOC103470503	Indoleamine 2,3-dioxygenase 1. (422 aa)
	aadat	Aminoadipate aminotransferase. (437 aa)
	kmo	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (480 aa)
	afmid	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (292 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103470503	LOC103476765	ENSPREP00000009451	ENSPREP00000017440	Indoleamine 2,3-dioxygenase 1.	Uncharacterized protein.	0.903
LOC103470503	afmid	ENSPREP00000009451	ENSPREP00000000586	Indoleamine 2,3-dioxygenase 1.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.939
LOC103470503	kmo	ENSPREP00000009451	ENSPREP00000004178	Indoleamine 2,3-dioxygenase 1.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.556
LOC103470503	kyat1	ENSPREP00000009451	ENSPREP00000032441	Indoleamine 2,3-dioxygenase 1.	Kynurenine aminotransferase 1.	0.424
LOC103470503	kyat3	ENSPREP00000009451	ENSPREP00000021246	Indoleamine 2,3-dioxygenase 1.	Kynurenine aminotransferase 3.	0.424
LOC103470503	kynu	ENSPREP00000009451	ENSPREP00000032472	Indoleamine 2,3-dioxygenase 1.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.955
LOC103470503	tdo2	ENSPREP00000009451	ENSPREP00000014848	Indoleamine 2,3-dioxygenase 1.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.952
LOC103476765	LOC103470503	ENSPREP00000017440	ENSPREP00000009451	Uncharacterized protein.	Indoleamine 2,3-dioxygenase 1.	0.903
LOC103476765	afmid	ENSPREP00000017440	ENSPREP00000000586	Uncharacterized protein.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.939
LOC103476765	kmo	ENSPREP00000017440	ENSPREP00000004178	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.556
LOC103476765	kyat1	ENSPREP00000017440	ENSPREP00000032441	Uncharacterized protein.	Kynurenine aminotransferase 1.	0.424
LOC103476765	kyat3	ENSPREP00000017440	ENSPREP00000021246	Uncharacterized protein.	Kynurenine aminotransferase 3.	0.424
LOC103476765	kynu	ENSPREP00000017440	ENSPREP00000032472	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.955
LOC103476765	tdo2	ENSPREP00000017440	ENSPREP00000014848	Uncharacterized protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.945
aadat	afmid	ENSPREP00000004633	ENSPREP00000000586	Aminoadipate aminotransferase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.937
aadat	aldh8a1	ENSPREP00000004633	ENSPREP00000016632	Aminoadipate aminotransferase.	Aldehyde dehydrogenase 8 family, member A1; Belongs to the aldehyde dehydrogenase family.	0.435
aadat	got2	ENSPREP00000004633	ENSPREP00000021995	Aminoadipate aminotransferase.	Aspartate aminotransferase.	0.605
aadat	kmo	ENSPREP00000004633	ENSPREP00000004178	Aminoadipate aminotransferase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.957
aadat	kyat1	ENSPREP00000004633	ENSPREP00000032441	Aminoadipate aminotransferase.	Kynurenine aminotransferase 1.	0.943
aadat	kyat3	ENSPREP00000004633	ENSPREP00000021246	Aminoadipate aminotransferase.	Kynurenine aminotransferase 3.	0.943