(21 nodes) Necrotic cell death network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103480376	Uncharacterized protein. (861 aa)
	ENSPREP00000014253	Uncharacterized protein. (149 aa)
	ENSPREP00000020797	TNFR-Cys domain-containing protein. (307 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	itpk1	Inositol-tetrakisphosphate 1-kinase b. (393 aa)
	LOC103470751	Protein kinase domain-containing protein. (488 aa)
	ENSPREP00000031693	Gasdermin domain-containing protein. (160 aa)
	LOC103481249	Interferon regulatory factor 3. (465 aa)
	LOC103465561	Cylindromatosis (turban tumor syndrome), b. (715 aa)
	Alkbh7	AlkB homolog 7. (158 aa)
	gsdme	Gasdermin Eb. (448 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	ENSPREP00000002926	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (196 aa)
	LOC103477745	Tumor necrosis factor b (TNF superfamily, member 2). (249 aa)
	ipmk	Kinase; Belongs to the inositol phosphokinase (IPK) family. (472 aa)
	LOC103466952	Uncharacterized protein. (163 aa)
	LOC103479635	Death domain-containing protein. (536 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (924 aa)
	LOC103465116	Ninjurin 1. (142 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	LOC103463417	Cylindromatosis (turban tumor syndrome), like. (616 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC103481249	ENSPREP00000013021	ENSPREP00000032515	BCL2 associated X, apoptosis regulator.	Interferon regulatory factor 3.	0.502
ENSPREP00000002275	ENSPREP00000002926	ENSPREP00000002275	ENSPREP00000002926	DED domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.959
ENSPREP00000002275	ENSPREP00000020797	ENSPREP00000002275	ENSPREP00000020797	DED domain-containing protein.	TNFR-Cys domain-containing protein.	0.997
ENSPREP00000002275	LOC103463417	ENSPREP00000002275	ENSPREP00000013219	DED domain-containing protein.	Cylindromatosis (turban tumor syndrome), like.	0.624
ENSPREP00000002275	LOC103465561	ENSPREP00000002275	ENSPREP00000032899	DED domain-containing protein.	Cylindromatosis (turban tumor syndrome), b.	0.624
ENSPREP00000002275	LOC103466013	ENSPREP00000002275	ENSPREP00000021307	DED domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.991
ENSPREP00000002275	LOC103470751	ENSPREP00000002275	ENSPREP00000027001	DED domain-containing protein.	Protein kinase domain-containing protein.	0.671
ENSPREP00000002275	LOC103479635	ENSPREP00000002275	ENSPREP00000009477	DED domain-containing protein.	Death domain-containing protein.	0.984
ENSPREP00000002275	LOC103480376	ENSPREP00000002275	ENSPREP00000013878	DED domain-containing protein.	Uncharacterized protein.	0.600
ENSPREP00000002275	cyld	ENSPREP00000002275	ENSPREP00000010113	DED domain-containing protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.624
ENSPREP00000002926	ENSPREP00000002275	ENSPREP00000002926	ENSPREP00000002275	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	DED domain-containing protein.	0.959
ENSPREP00000002926	ENSPREP00000020797	ENSPREP00000002926	ENSPREP00000020797	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.985
ENSPREP00000002926	LOC103466013	ENSPREP00000002926	ENSPREP00000021307	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.507
ENSPREP00000002926	LOC103479635	ENSPREP00000002926	ENSPREP00000009477	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Death domain-containing protein.	0.726
ENSPREP00000020797	ENSPREP00000002275	ENSPREP00000020797	ENSPREP00000002275	TNFR-Cys domain-containing protein.	DED domain-containing protein.	0.997
ENSPREP00000020797	ENSPREP00000002926	ENSPREP00000020797	ENSPREP00000002926	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.985
ENSPREP00000020797	LOC103466013	ENSPREP00000020797	ENSPREP00000021307	TNFR-Cys domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.529
ENSPREP00000020797	LOC103479635	ENSPREP00000020797	ENSPREP00000009477	TNFR-Cys domain-containing protein.	Death domain-containing protein.	0.844
ENSPREP00000031693	LOC103470751	ENSPREP00000031693	ENSPREP00000027001	Gasdermin domain-containing protein.	Protein kinase domain-containing protein.	0.523
LOC103463417	ENSPREP00000002275	ENSPREP00000013219	ENSPREP00000002275	Cylindromatosis (turban tumor syndrome), like.	DED domain-containing protein.	0.624