(36 nodes) Protein K63-linked ubiquitination network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479460	Ring finger protein 126. (310 aa)
	BFAR	Bifunctional apoptosis regulator. (457 aa)
	ENSPREP00000001588	Ubiquitin-conjugating enzyme E2 variant 1. (146 aa)
	itch	E3 ubiquitin-protein ligase. (840 aa)
	rnf213	Ring finger protein 213a. (4763 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)
	hectd1	HECT domain containing 1. (2572 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	rnf126	RING-type domain-containing protein. (329 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
	LOC103467191	Si:ch211-113e8.10. (763 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (149 aa)
	ube2g1	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	rnf4	RING-type domain-containing protein. (191 aa)
	ENSPREP00000016817	RING-type domain-containing protein. (1774 aa)
	ube2n	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	arih2	RBR-type E3 ubiquitin transferase. (500 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	ENSPREP00000021082	Ring finger protein 213b. (3184 aa)
	LOC103469572	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC103473816	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	ENSPREP00000023563	Im:7152348. (185 aa)
	LOC103464828	E3 ubiquitin-protein ligase. (869 aa)
	LOC103469522	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	rnf115	Ring finger protein 115. (314 aa)
	ENSPREP00000026492	SEFIR domain-containing protein. (109 aa)
	LOC103466094	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (209 aa)
	LOC103472685	Si:ch211-81a5.1. (264 aa)
	LOC103473320	TNF receptor-associated factor. (494 aa)
	LOC103467425	Zgc:194242. (404 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1351 aa)
	traf3ip2	SEFIR domain-containing protein. (418 aa)
	LOC103465507	UBIQUITIN_CONJUGAT_2 domain-containing protein. (134 aa)
	ENSPREP00000031399	Ring finger protein 168. (425 aa)
	rnf152	Ring finger protein 152. (177 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	ENSPREP00000001588	ENSPREP00000000174	ENSPREP00000001588	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 1.	0.410
BFAR	LOC103465507	ENSPREP00000000174	ENSPREP00000031137	Bifunctional apoptosis regulator.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.410
BFAR	rnf8	ENSPREP00000000174	ENSPREP00000012303	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.522
BFAR	ube2v2	ENSPREP00000000174	ENSPREP00000012570	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 2.	0.410
ENSPREP00000001588	BFAR	ENSPREP00000001588	ENSPREP00000000174	Ubiquitin-conjugating enzyme E2 variant 1.	Bifunctional apoptosis regulator.	0.410
ENSPREP00000001588	ENSPREP00000020277	ENSPREP00000001588	ENSPREP00000020277	Ubiquitin-conjugating enzyme E2 variant 1.	RBR-type E3 ubiquitin transferase.	0.642
ENSPREP00000001588	ENSPREP00000031399	ENSPREP00000001588	ENSPREP00000031399	Ubiquitin-conjugating enzyme E2 variant 1.	Ring finger protein 168.	0.705
ENSPREP00000001588	LOC103466094	ENSPREP00000001588	ENSPREP00000026505	Ubiquitin-conjugating enzyme E2 variant 1.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.945
ENSPREP00000001588	LOC103467425	ENSPREP00000001588	ENSPREP00000029182	Ubiquitin-conjugating enzyme E2 variant 1.	Zgc:194242.	0.667
ENSPREP00000001588	LOC103469522	ENSPREP00000001588	ENSPREP00000023813	Ubiquitin-conjugating enzyme E2 variant 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.744
ENSPREP00000001588	UBE2O	ENSPREP00000001588	ENSPREP00000029489	Ubiquitin-conjugating enzyme E2 variant 1.	Ubiquitin conjugating enzyme E2 O.	0.719
ENSPREP00000001588	rnf4	ENSPREP00000001588	ENSPREP00000016718	Ubiquitin-conjugating enzyme E2 variant 1.	RING-type domain-containing protein.	0.627
ENSPREP00000001588	rnf8	ENSPREP00000001588	ENSPREP00000012303	Ubiquitin-conjugating enzyme E2 variant 1.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.826
ENSPREP00000001588	traf6	ENSPREP00000001588	ENSPREP00000005082	Ubiquitin-conjugating enzyme E2 variant 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.665
ENSPREP00000001588	ube2g1	ENSPREP00000001588	ENSPREP00000012709	Ubiquitin-conjugating enzyme E2 variant 1.	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.744
ENSPREP00000001588	ube2n	ENSPREP00000001588	ENSPREP00000017852	Ubiquitin-conjugating enzyme E2 variant 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.945
ENSPREP00000020277	ENSPREP00000001588	ENSPREP00000020277	ENSPREP00000001588	RBR-type E3 ubiquitin transferase.	Ubiquitin-conjugating enzyme E2 variant 1.	0.642
ENSPREP00000020277	LOC103465507	ENSPREP00000020277	ENSPREP00000031137	RBR-type E3 ubiquitin transferase.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.642
ENSPREP00000020277	LOC103466094	ENSPREP00000020277	ENSPREP00000026505	RBR-type E3 ubiquitin transferase.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.879
ENSPREP00000020277	LOC103467425	ENSPREP00000020277	ENSPREP00000029182	RBR-type E3 ubiquitin transferase.	Zgc:194242.	0.616