(40 nodes) Regulation of protein processing network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103477419	Cystatin domain-containing protein. (163 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (404 aa)
	LOC103479906	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (407 aa)
	rhbdd1	Rhomboid domain containing 1. (312 aa)
	LOC103462926	Golgi glycoprotein 1b. (1144 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (350 aa)
	LOC103458505	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (202 aa)
	LOC103472693	Protein S100; Belongs to the S-100 family. (100 aa)
	cntn2	Contactin 2. (1034 aa)
	ENSPREP00000030267	Growth arrest-specific 1b. (256 aa)
	cast	Uncharacterized protein. (643 aa)
	rnf139	Ring finger protein 139. (701 aa)
	bag2	BCL2 associated athanogene 2. (208 aa)
	ENSPREP00000010762	Uncharacterized protein. (165 aa)
	LOC103462620	Uncharacterized protein. (254 aa)
	Gas1	Growth arrest-specific 1a. (254 aa)
	plgrkt	Plasminogen receptor, C-terminal lysine transmembrane protein. (167 aa)
	clec3b	C-type lectin domain family 3, member Ba. (198 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	LOC103479663	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (477 aa)
	LOC103474919	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (762 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (464 aa)
	spon1	Spondin 1a. (806 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (306 aa)
	chac1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (196 aa)
	cln3	Battenin. (480 aa)
	prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
	LOC103466243	Uncharacterized protein. (782 aa)
	glg1	Golgi glycoprotein 1a. (1136 aa)
	il1r2	Uncharacterized protein. (406 aa)
	LOC103459868	SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
	LOC103480133	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103468785	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC103465711	Protein phosphatase 1, regulatory subunit 15B. (553 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103471866	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (308 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (427 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000030267	Gas1	ENSPREP00000030267	ENSPREP00000013011	Growth arrest-specific 1b.	Growth arrest-specific 1a.	0.903
ENSPREP00000030267	LOC103462620	ENSPREP00000030267	ENSPREP00000012147	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
Gas1	ENSPREP00000030267	ENSPREP00000013011	ENSPREP00000030267	Growth arrest-specific 1a.	Growth arrest-specific 1b.	0.903
Gas1	LOC103462620	ENSPREP00000013011	ENSPREP00000012147	Growth arrest-specific 1a.	Uncharacterized protein.	0.906
LOC103458505	chac1	ENSPREP00000028836	ENSPREP00000020291	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.901
LOC103462620	ENSPREP00000030267	ENSPREP00000012147	ENSPREP00000030267	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
LOC103462620	Gas1	ENSPREP00000012147	ENSPREP00000013011	Uncharacterized protein.	Growth arrest-specific 1a.	0.906
LOC103462926	glg1	ENSPREP00000027906	ENSPREP00000002471	Golgi glycoprotein 1b.	Golgi glycoprotein 1a.	0.901
LOC103468785	LOC103479663	ENSPREP00000006192	ENSPREP00000014181	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.900
LOC103468785	prkaca	ENSPREP00000006192	ENSPREP00000000445	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103468785	prkacb	ENSPREP00000006192	ENSPREP00000021366	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103474919	LOC103480133	ENSPREP00000015420	ENSPREP00000004625	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.670
LOC103479663	LOC103468785	ENSPREP00000014181	ENSPREP00000006192	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
LOC103479663	prkaca	ENSPREP00000014181	ENSPREP00000000445	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103479663	prkacb	ENSPREP00000014181	ENSPREP00000021366	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103480133	LOC103474919	ENSPREP00000004625	ENSPREP00000015420	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.	0.670
chac1	LOC103458505	ENSPREP00000020291	ENSPREP00000028836	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.901
glg1	LOC103462926	ENSPREP00000002471	ENSPREP00000027906	Golgi glycoprotein 1a.	Golgi glycoprotein 1b.	0.901
prkaca	LOC103468785	ENSPREP00000000445	ENSPREP00000006192	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
prkaca	LOC103479663	ENSPREP00000000445	ENSPREP00000014181	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.900