(94 nodes) Growth factor receptor binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479460	Ring finger protein 126. (310 aa)
	LOC103459747	PX domain-containing protein. (433 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	ecm1	Uncharacterized protein. (482 aa)
	ENSPREP00000024153	Uncharacterized protein. (676 aa)
	LOC103469145	GRB2 related adaptor protein a. (214 aa)
	LOC103466425	Uncharacterized protein. (380 aa)
	LOC103466432	Si:ch73-330k17.3. (167 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	Vegfb	Vascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (94 aa)
	atxn2	Ataxin 2. (1064 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	Pgf	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (152 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (229 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103470686	Interleukin-1. (247 aa)
	LOC103465960	Sorting nexin 1a. (743 aa)
	LOC103465945	Leucine rich repeat and Ig domain containing 1a. (615 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	il6st	Uncharacterized protein. (896 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	flrt2	Fibronectin leucine rich transmembrane protein 2. (651 aa)
	LOC103479763	Neurturin. (215 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (765 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	LOC103461636	Sorting nexin 4. (455 aa)
	LOC103471818	Leucine rich repeat and Ig domain containing 2a. (613 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (477 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (361 aa)
	LOC103473660	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (503 aa)
	LOC103469984	EGF-like domain-containing protein. (176 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	LOC103478037	Interleukin 11a. (200 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	LOC103479139	TGF_BETA_2 domain-containing protein. (295 aa)
	glmn	Glomulin, FKBP associated protein a. (611 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	rnf126	RING-type domain-containing protein. (329 aa)
	LOC103460066	Uncharacterized protein. (496 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)
	LOC103476642	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
	flrt3	Fibronectin leucine rich transmembrane 3. (650 aa)
	LOC103471871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSPREP00000009358	Uncharacterized protein. (158 aa)
	ENSPREP00000009325	GRB2 related adaptor protein b. (229 aa)
	snx1	Sorting nexin 1b. (491 aa)
	LOC103471128	Heparin-binding EGF-like growth factor a. (236 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	LOC103462684	Neuroplastin b. (379 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	LOC103462722	Leucine rich repeat and Ig domain containing 1b. (623 aa)
	ENSPREP00000005271	Uncharacterized protein. (210 aa)
	LOC103473479	EGF-like domain-containing protein. (217 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	Tgfa	Transforming growth factor, alpha. (166 aa)
	PDCL3	Phosducin like 3. (238 aa)
	frs3	Fibroblast growth factor receptor substrate 3. (627 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103471324	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	NCSTN	Nicastrin. (699 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	PSPN	Persephin. (163 aa)
	LOC103476211	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (229 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	esm1	Endothelial cell-specific molecule 1. (186 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	LOC103477639	Leucine rich repeat and Ig domain containing 4b. (604 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (888 aa)
	vegfd	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (286 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	GREM1	Gremlin. (182 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	pdgfd	Platelet derived growth factor d. (359 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	ENSPREP00000031993	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (131 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fam83b	Family with sequence similarity 83 member B. (889 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC103457801	Fibronectin leucine rich transmembrane protein 2. (659 aa)
	snx2	Sorting nexin 2. (539 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
Adam17	Tgfa	ENSPREP00000021960	ENSPREP00000003483	Pep_M12B_propep domain-containing protein.	Transforming growth factor, alpha.	0.463
ENSPREP00000004603	ENSPREP00000010497	ENSPREP00000004603	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.447
ENSPREP00000004603	LOC103457801	ENSPREP00000004603	ENSPREP00000027531	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibronectin leucine rich transmembrane protein 2.	0.401
ENSPREP00000004603	LOC103473660	ENSPREP00000004603	ENSPREP00000014108	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	LOC103476521	ENSPREP00000004603	ENSPREP00000029747	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.511
ENSPREP00000004603	Pgf	ENSPREP00000004603	ENSPREP00000020974	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.493
ENSPREP00000004603	fgf10	ENSPREP00000004603	ENSPREP00000014875	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	fgf19	ENSPREP00000004603	ENSPREP00000002527	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	fgf22	ENSPREP00000004603	ENSPREP00000011331	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
ENSPREP00000004603	fgf23	ENSPREP00000004603	ENSPREP00000033759	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	fgf3	ENSPREP00000004603	ENSPREP00000002583	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.438
ENSPREP00000004603	fgf5	ENSPREP00000004603	ENSPREP00000004455	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
ENSPREP00000004603	fgf7	ENSPREP00000004603	ENSPREP00000012669	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.416
ENSPREP00000004603	flrt2	ENSPREP00000004603	ENSPREP00000017788	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibronectin leucine rich transmembrane protein 2.	0.401
ENSPREP00000004603	flrt3	ENSPREP00000004603	ENSPREP00000010026	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibronectin leucine rich transmembrane 3.	0.472
ENSPREP00000004603	grb2	ENSPREP00000004603	ENSPREP00000022510	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.488
ENSPREP00000006768	LOC103457801	ENSPREP00000006768	ENSPREP00000027531	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibronectin leucine rich transmembrane protein 2.	0.441
ENSPREP00000006768	LOC103462291	ENSPREP00000006768	ENSPREP00000002555	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429