(43 nodes) Neuron death network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCSTN	Nicastrin. (699 aa)
	ENSPREP00000001630	RHD domain-containing protein. (238 aa)
	Nfatc4	Uncharacterized protein. (238 aa)
	dnajc5b	DnaJ heat shock protein family (Hsp40) member C5 beta. (197 aa)
	spg11	SPG11 vesicle trafficking associated, spatacsin. (2269 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (690 aa)
	LOC103467735	DnaJ (Hsp40) homolog, subfamily C, member 5aa. (199 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1057 aa)
	bag5	BCL2 associated athanogene 5. (481 aa)
	tmtc4	Transmembrane O-mannosyltransferase targeting cadherins 4. (741 aa)
	LOC103461430	Uncharacterized protein. (251 aa)
	lig4	DNA ligase. (908 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	LOC103474128	Diablo, IAP-binding mitochondrial protein a. (233 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	ngfr	Nerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	rapsn	Receptor-associated protein of the synapse, 43kD. (395 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (427 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	LOC103469600	Citron rho-interacting serine/threonine kinase b. (1537 aa)
	pjvk	Pejvakin. (356 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	LOC103458337	J domain-containing protein. (181 aa)
	bhlhe23	Basic helix-loop-helix family, member e23. (227 aa)
	dnajc5g	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a. (177 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1284 aa)
	sncb	Synuclein, beta; Belongs to the synuclein family. (127 aa)
	pigt	Phosphatidylinositol glycan anchor biosynthesis, class T. (641 aa)
	siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	LOC103461905	DnaJ (Hsp40) homolog, subfamily C, member 5ab. (196 aa)
	fam162a	Family with sequence similarity 162 member A. (142 aa)
	ENSPREP00000030231	Uncharacterized protein. (800 aa)
	ENSPREP00000030263	Uncharacterized protein. (812 aa)
	ENSPREP00000030269	Uncharacterized protein. (785 aa)
	LOC103475853	Pyr_redox_2 domain-containing protein. (552 aa)
	LOC103464971	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1972 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	LOC103481795	Nerve growth factor receptor b. (354 aa)
	LOC103475891	Apoptosis inducing factor mitochondrion associated 1. (597 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC103461430	ENSPREP00000013021	ENSPREP00000009605	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.443
BAX	LOC103474128	ENSPREP00000013021	ENSPREP00000012529	BCL2 associated X, apoptosis regulator.	Diablo, IAP-binding mitochondrial protein a.	0.443
BAX	LOC103475853	ENSPREP00000013021	ENSPREP00000030607	BCL2 associated X, apoptosis regulator.	Pyr_redox_2 domain-containing protein.	0.916
BAX	LOC103475891	ENSPREP00000013021	ENSPREP00000034202	BCL2 associated X, apoptosis regulator.	Apoptosis inducing factor mitochondrion associated 1.	0.916
BAX	casp9	ENSPREP00000013021	ENSPREP00000019950	BCL2 associated X, apoptosis regulator.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.499
ENSPREP00000001630	Nfatc4	ENSPREP00000001630	ENSPREP00000001665	RHD domain-containing protein.	Uncharacterized protein.	0.865
ENSPREP00000002275	casp9	ENSPREP00000002275	ENSPREP00000019950	DED domain-containing protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.686
ENSPREP00000030231	casp9	ENSPREP00000030231	ENSPREP00000019950	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.412
ENSPREP00000030263	casp9	ENSPREP00000030263	ENSPREP00000019950	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.412
ENSPREP00000030269	casp9	ENSPREP00000030269	ENSPREP00000019950	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.412
LOC103461430	BAX	ENSPREP00000009605	ENSPREP00000013021	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.443
LOC103461430	LOC103474128	ENSPREP00000009605	ENSPREP00000012529	Uncharacterized protein.	Diablo, IAP-binding mitochondrial protein a.	0.901
LOC103461430	casp9	ENSPREP00000009605	ENSPREP00000019950	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.701
LOC103474128	BAX	ENSPREP00000012529	ENSPREP00000013021	Diablo, IAP-binding mitochondrial protein a.	BCL2 associated X, apoptosis regulator.	0.443
LOC103474128	LOC103461430	ENSPREP00000012529	ENSPREP00000009605	Diablo, IAP-binding mitochondrial protein a.	Uncharacterized protein.	0.901
LOC103474128	casp9	ENSPREP00000012529	ENSPREP00000019950	Diablo, IAP-binding mitochondrial protein a.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.701
LOC103475853	BAX	ENSPREP00000030607	ENSPREP00000013021	Pyr_redox_2 domain-containing protein.	BCL2 associated X, apoptosis regulator.	0.916
LOC103475853	LOC103475891	ENSPREP00000030607	ENSPREP00000034202	Pyr_redox_2 domain-containing protein.	Apoptosis inducing factor mitochondrion associated 1.	0.900
LOC103475853	casp9	ENSPREP00000030607	ENSPREP00000019950	Pyr_redox_2 domain-containing protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.440
LOC103475891	BAX	ENSPREP00000034202	ENSPREP00000013021	Apoptosis inducing factor mitochondrion associated 1.	BCL2 associated X, apoptosis regulator.	0.916