(12 nodes) U2-type catalytic step 1 spliceosome network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	eif4a3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (406 aa)
	prpf8	Pre-mRNA processing factor 8. (2358 aa)
	rbm8a	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (160 aa)
	LOC103460347	ISY1 splicing factor homolog. (235 aa)
	casc3	Casc3 exon junction complex subunit. (662 aa)
	yju2	YJU2 splicing factor homolog. (344 aa)
	LOC103458447	Src homology 2 domain containing transforming protein D, a. (415 aa)
	snrnp200	Small nuclear ribonucleoprotein 200 (U5). (2136 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (854 aa)
	Cwc25	Cir_N domain-containing protein. (64 aa)
	rbm22	RNA binding motif protein 22. (426 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cwc25	LOC103458447	ENSPREP00000005308	ENSPREP00000015749	Cir_N domain-containing protein.	Src homology 2 domain containing transforming protein D, a.	0.990
Cwc25	LOC103460347	ENSPREP00000005308	ENSPREP00000022403	Cir_N domain-containing protein.	ISY1 splicing factor homolog.	0.958
Cwc25	casc3	ENSPREP00000005308	ENSPREP00000017548	Cir_N domain-containing protein.	Casc3 exon junction complex subunit.	0.559
Cwc25	cwc22	ENSPREP00000005308	ENSPREP00000006247	Cir_N domain-containing protein.	CWC22 spliceosome associated protein homolog.	0.985
Cwc25	eif4a3	ENSPREP00000005308	ENSPREP00000008805	Cir_N domain-containing protein.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.716
Cwc25	prpf19	ENSPREP00000005308	ENSPREP00000003500	Cir_N domain-containing protein.	Pre-mRNA processing factor 19.	0.986
Cwc25	prpf8	ENSPREP00000005308	ENSPREP00000032359	Cir_N domain-containing protein.	Pre-mRNA processing factor 8.	0.962
Cwc25	rbm22	ENSPREP00000005308	ENSPREP00000005089	Cir_N domain-containing protein.	RNA binding motif protein 22.	0.920
Cwc25	rbm8a	ENSPREP00000005308	ENSPREP00000026004	Cir_N domain-containing protein.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.559
Cwc25	snrnp200	ENSPREP00000005308	ENSPREP00000013242	Cir_N domain-containing protein.	Small nuclear ribonucleoprotein 200 (U5).	0.991
Cwc25	yju2	ENSPREP00000005308	ENSPREP00000015829	Cir_N domain-containing protein.	YJU2 splicing factor homolog.	0.994
LOC103458447	Cwc25	ENSPREP00000015749	ENSPREP00000005308	Src homology 2 domain containing transforming protein D, a.	Cir_N domain-containing protein.	0.990
LOC103458447	LOC103460347	ENSPREP00000015749	ENSPREP00000022403	Src homology 2 domain containing transforming protein D, a.	ISY1 splicing factor homolog.	0.928
LOC103458447	casc3	ENSPREP00000015749	ENSPREP00000017548	Src homology 2 domain containing transforming protein D, a.	Casc3 exon junction complex subunit.	0.487
LOC103458447	cwc22	ENSPREP00000015749	ENSPREP00000006247	Src homology 2 domain containing transforming protein D, a.	CWC22 spliceosome associated protein homolog.	0.974
LOC103458447	eif4a3	ENSPREP00000015749	ENSPREP00000008805	Src homology 2 domain containing transforming protein D, a.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.641
LOC103458447	prpf19	ENSPREP00000015749	ENSPREP00000003500	Src homology 2 domain containing transforming protein D, a.	Pre-mRNA processing factor 19.	0.888
LOC103458447	prpf8	ENSPREP00000015749	ENSPREP00000032359	Src homology 2 domain containing transforming protein D, a.	Pre-mRNA processing factor 8.	0.894
LOC103458447	rbm22	ENSPREP00000015749	ENSPREP00000005089	Src homology 2 domain containing transforming protein D, a.	RNA binding motif protein 22.	0.634
LOC103458447	rbm8a	ENSPREP00000015749	ENSPREP00000026004	Src homology 2 domain containing transforming protein D, a.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.487