(65 nodes) Catalytic step 2 spliceosome network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	snrnp40	Small nuclear ribonucleoprotein 40 (U5). (347 aa)
	lsm7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (130 aa)
	sf3a2	Splicing factor 3a, subunit 2. (294 aa)
	prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (1016 aa)
	snrpe	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	dhx35	DEAH-box helicase 35. (699 aa)
	snw1	SNW domain containing 1. (536 aa)
	cwc27	CWC27 spliceosome associated cyclophilin. (455 aa)
	ppwd1	Peptidylprolyl isomerase domain and WD repeat containing 1. (632 aa)
	hnrnpr	Heterogeneous nuclear ribonucleoprotein R. (620 aa)
	sf3b6	Splicing factor 3b, subunit 6. (231 aa)
	sf3b1	Splicing factor 3b, subunit 1. (1315 aa)
	ENSPREP00000029432	Uncharacterized protein. (223 aa)
	wdr25	WD_REPEATS_REGION domain-containing protein. (228 aa)
	syncrip	Synaptotagmin binding, cytoplasmic RNA interacting protein, like. (551 aa)
	zcchc8	Zinc finger, CCHC domain containing 8. (685 aa)
	prpf8	Pre-mRNA processing factor 8. (2358 aa)
	cwc15	CWC15 spliceosome associated protein homolog. (238 aa)
	lsm3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	Snrpf	Small nuclear ribonucleoprotein polypeptide F. (87 aa)
	dhx38	DEAH (Asp-Glu-Ala-His) box polypeptide 38. (1229 aa)
	plrg1	Pleiotropic regulator 1. (510 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (756 aa)
	wdr83	WD repeat domain containing 83. (426 aa)
	clg13h19orf54	Zgc:153119. (295 aa)
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
	ppil1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (581 aa)
	snrpa1	Small nuclear ribonucleoprotein polypeptide A. (254 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)
	prpf4b	Pre-mRNA processing factor 4Bb. (984 aa)
	sf3b2	Splicing factor 3b, subunit 2. (853 aa)
	srrm1	Serine/arginine repetitive matrix 1. (839 aa)
	syf2	SYF2 pre-mRNA-splicing factor. (238 aa)
	mtrex	Mtr4 exosome RNA helicase. (1053 aa)
	rbm22	RNA binding motif protein 22. (426 aa)
	Snrpd2	Small nuclear ribonucleoprotein Sm D2. (115 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (854 aa)
	DDX41	DEAD-box helicase 41. (614 aa)
	snrpg	Small nuclear ribonucleoprotein G. (76 aa)
	ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (158 aa)
	xab2	XPA binding protein 2. (912 aa)
	ddx23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23. (805 aa)
	snrpd1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1325 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (122 aa)
	pnn	Pinin, desmosome associated protein. (669 aa)
	ENSPREP00000012190	G patch domain containing 1. (769 aa)
	EFTUD2	Elongation factor Tu GTP binding domain containing 2. (389 aa)
	ENSPREP00000012415	EFG_C domain-containing protein. (178 aa)
	snrnp200	Small nuclear ribonucleoprotein 200 (U5). (2136 aa)
	bcas2	BCAS2 pre-mRNA processing factor. (243 aa)
	rbmx	RNA binding motif protein X-linked. (383 aa)
	sf3a1	Splicing factor 3a, subunit 1. (786 aa)
	ess2	Ess-2 splicing factor homolog. (479 aa)
	dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8. (1258 aa)
	crnkl1	Crooked neck pre-mRNA splicing factor 1. (749 aa)
	ppil2	Peptidylprolyl isomerase (cyclophilin)-like 2. (525 aa)
	sf3a3	Splicing factor 3a, subunit 3. (502 aa)
	LOC103460347	ISY1 splicing factor homolog. (235 aa)
	ENSPREP00000022980	Small nuclear ribonucleoprotein-associated protein. (217 aa)
	ENSPREP00000023437	Uncharacterized protein. (97 aa)
	hnrnpm	Heterogeneous nuclear ribonucleoprotein M. (723 aa)
	dhx34	DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1137 aa)
	lsm2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (93 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX41	ENSPREP00000012190	ENSPREP00000007803	ENSPREP00000012190	DEAD-box helicase 41.	G patch domain containing 1.	0.631
DDX41	ENSPREP00000029432	ENSPREP00000007803	ENSPREP00000029432	DEAD-box helicase 41.	Uncharacterized protein.	0.617
DDX41	cdc40	ENSPREP00000007803	ENSPREP00000003161	DEAD-box helicase 41.	Cell division cycle 40 homolog (S. cerevisiae).	0.680
DDX41	cwc22	ENSPREP00000007803	ENSPREP00000006247	DEAD-box helicase 41.	CWC22 spliceosome associated protein homolog.	0.677
DDX41	cwc27	ENSPREP00000007803	ENSPREP00000027209	DEAD-box helicase 41.	CWC27 spliceosome associated cyclophilin.	0.422
DDX41	ddx23	ENSPREP00000007803	ENSPREP00000010375	DEAD-box helicase 41.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23.	0.519
DDX41	dhx34	ENSPREP00000007803	ENSPREP00000024312	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 34.	0.671
DDX41	dhx35	ENSPREP00000007803	ENSPREP00000026925	DEAD-box helicase 41.	DEAH-box helicase 35.	0.671
DDX41	dhx38	ENSPREP00000007803	ENSPREP00000034266	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 38.	0.730
DDX41	dhx8	ENSPREP00000007803	ENSPREP00000017415	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 8.	0.671
DDX41	mtrex	ENSPREP00000007803	ENSPREP00000004435	DEAD-box helicase 41.	Mtr4 exosome RNA helicase.	0.666
DDX41	ppie	ENSPREP00000007803	ENSPREP00000002091	DEAD-box helicase 41.	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	0.547
DDX41	ppil1	ENSPREP00000007803	ENSPREP00000002465	DEAD-box helicase 41.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.692
DDX41	ppil2	ENSPREP00000007803	ENSPREP00000019637	DEAD-box helicase 41.	Peptidylprolyl isomerase (cyclophilin)-like 2.	0.510
DDX41	ppil3	ENSPREP00000007803	ENSPREP00000008198	DEAD-box helicase 41.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.676
DDX41	ppwd1	ENSPREP00000007803	ENSPREP00000027276	DEAD-box helicase 41.	Peptidylprolyl isomerase domain and WD repeat containing 1.	0.853
DDX41	srrm1	ENSPREP00000007803	ENSPREP00000003793	DEAD-box helicase 41.	Serine/arginine repetitive matrix 1.	0.676
DDX41	wdr25	ENSPREP00000007803	ENSPREP00000029451	DEAD-box helicase 41.	WD_REPEATS_REGION domain-containing protein.	0.617
EFTUD2	ENSPREP00000012190	ENSPREP00000012394	ENSPREP00000012190	Elongation factor Tu GTP binding domain containing 2.	G patch domain containing 1.	0.453
EFTUD2	ENSPREP00000012415	ENSPREP00000012394	ENSPREP00000012415	Elongation factor Tu GTP binding domain containing 2.	EFG_C domain-containing protein.	0.900