(41 nodes) Cellular response to mechanical stimulus network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108167062	Uncharacterized protein; Belongs to the peptidase C14A family. (224 aa)
	LOC103462560	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (319 aa)
	ENSPREP00000001831	Uncharacterized protein. (301 aa)
	ENSPREP00000001895	Piezo_RRas_bdg domain-containing protein. (569 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	LOC103478931	Uncharacterized protein; Belongs to the peptidase C14A family. (444 aa)
	LOC103462295	Zgc:153993. (263 aa)
	LOC103475799	F11 receptor, tandem duplicate 1. (308 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	ptger4	Prostaglandin E receptor 4 (subtype EP4) b. (456 aa)
	tnfrsf18	CD40 molecule, TNF receptor superfamily member 5. (314 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	ENSPREP00000026798	Transmembrane protein 150C. (201 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	PIEZO2	Piezo-type mechanosensitive ion channel component. (2643 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	LOC103473840	Uncharacterized protein. (582 aa)
	LOC103471448	Potassium channel, subfamily K, member 4a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (492 aa)
	ENSPREP00000022389	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	ENSPREP00000020797	TNFR-Cys domain-containing protein. (307 aa)
	ENSPREP00000019402	Protein kinase domain-containing protein. (201 aa)
	LOC103470686	Interleukin-1. (247 aa)
	LOC103462757	IRF tryptophan pentad repeat domain-containing protein. (268 aa)
	bnip3	BCL2 interacting protein 3. (178 aa)
	KCNK4	Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (326 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (333 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (464 aa)
	LOC103468661	Mitogen-activated protein kinase kinase kinase 14a. (869 aa)
	LOC103481612	ADP-ribosylation factor 2b. (786 aa)
	ENSPREP00000012469	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	piezo1	Piezo-type mechanosensitive ion channel component. (2314 aa)
	ENSPREP00000010780	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	LOC103459939	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (507 aa)
	LOC103475332	Interferon regulatory factor. (291 aa)
	bag3	BCL2 associated athanogene 3. (516 aa)
	LOC103473458	Zgc:73226. (215 aa)
	LOC103459167	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1052 aa)
	ENSPREP00000002617	Uncharacterized protein. (98 aa)
	ENSPREP00000002598	Uncharacterized protein. (117 aa)
	LOC103478932	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (389 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001831	ENSPREP00000001895	ENSPREP00000001831	ENSPREP00000001895	Uncharacterized protein.	Piezo_RRas_bdg domain-containing protein.	0.936
ENSPREP00000001895	ENSPREP00000001831	ENSPREP00000001895	ENSPREP00000001831	Piezo_RRas_bdg domain-containing protein.	Uncharacterized protein.	0.936
ENSPREP00000002275	ENSPREP00000020797	ENSPREP00000002275	ENSPREP00000020797	DED domain-containing protein.	TNFR-Cys domain-containing protein.	0.997
ENSPREP00000002275	LOC103459939	ENSPREP00000002275	ENSPREP00000008346	DED domain-containing protein.	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.996
ENSPREP00000002275	LOC103478931	ENSPREP00000002275	ENSPREP00000002444	DED domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.997
ENSPREP00000002275	LOC103478932	ENSPREP00000002275	ENSPREP00000002524	DED domain-containing protein.	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.990
ENSPREP00000002275	LOC108167062	ENSPREP00000002275	ENSPREP00000002554	DED domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.990
ENSPREP00000002275	casp2	ENSPREP00000002275	ENSPREP00000015138	DED domain-containing protein.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.607
ENSPREP00000002275	tnfrsf1a	ENSPREP00000002275	ENSPREP00000016244	DED domain-containing protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.936
ENSPREP00000019402	LOC103468661	ENSPREP00000019402	ENSPREP00000013046	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 14a.	0.558
ENSPREP00000019402	LOC103481612	ENSPREP00000019402	ENSPREP00000012735	Protein kinase domain-containing protein.	ADP-ribosylation factor 2b.	0.558
ENSPREP00000019402	map2k4	ENSPREP00000019402	ENSPREP00000026466	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.901
ENSPREP00000020797	ENSPREP00000002275	ENSPREP00000020797	ENSPREP00000002275	TNFR-Cys domain-containing protein.	DED domain-containing protein.	0.997
ENSPREP00000020797	LOC103459939	ENSPREP00000020797	ENSPREP00000008346	TNFR-Cys domain-containing protein.	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.931
ENSPREP00000020797	LOC103478931	ENSPREP00000020797	ENSPREP00000002444	TNFR-Cys domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.931
ENSPREP00000020797	LOC103478932	ENSPREP00000020797	ENSPREP00000002524	TNFR-Cys domain-containing protein.	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.842
ENSPREP00000020797	LOC108167062	ENSPREP00000020797	ENSPREP00000002554	TNFR-Cys domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.842
ENSPREP00000020797	casp2	ENSPREP00000020797	ENSPREP00000015138	TNFR-Cys domain-containing protein.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.559
ENSPREP00000020797	tnfrsf18	ENSPREP00000020797	ENSPREP00000031319	TNFR-Cys domain-containing protein.	CD40 molecule, TNF receptor superfamily member 5.	0.519
ENSPREP00000020797	tnfrsf1a	ENSPREP00000020797	ENSPREP00000016244	TNFR-Cys domain-containing protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.693