(58 nodes) Regulation of mononuclear cell migration network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103462560	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (319 aa)
	slc8b1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (522 aa)
	LOC103477151	Uncharacterized protein. (158 aa)
	mospd2	Motile sperm domain containing 2. (523 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	AIF1	Allograft inflammatory factor 1. (149 aa)
	LOC103480133	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	LOC103458658	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	LOC103475402	Serine/threonine kinase 10. (717 aa)
	LOC103478475	Formyl peptide receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	LOC103461379	Galectin. (233 aa)
	akirin1	Akirin 1. (186 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	stk39	Serine threonine kinase 39. (504 aa)
	ENSPREP00000010734	Uncharacterized protein. (93 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (1067 aa)
	LOC103465116	Ninjurin 1. (142 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	ENSPREP00000014253	Uncharacterized protein. (149 aa)
	ptk2	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (878 aa)
	CCN3	Cellular communication network factor 3. (349 aa)
	cxcl14	Chemokine (C-X-C motif) ligand 14. (99 aa)
	LOC103475221	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (942 aa)
	LOC103472469	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1080 aa)
	LOC103459415	Anoctamin. (918 aa)
	LOC103479265	SCY domain-containing protein. (151 aa)
	gdf11	Growth differentiation factor 11. (388 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	LOC103466445	ADAM metallopeptidase domain 10b. (781 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	LOC103457179	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ENSPREP00000022497	G_PROTEIN_RECEP_F1_2 domain-containing protein. (160 aa)
	ENSPREP00000022516	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ENSPREP00000022535	G_PROTEIN_RECEP_F1_2 domain-containing protein. (363 aa)
	LOC103457880	Galectin. (300 aa)
	LOC103467541	Colony stimulating factor 1b (macrophage). (266 aa)
	ENSPREP00000023825	SH2 domain-containing protein. (93 aa)
	ecm1	Uncharacterized protein. (482 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	LOC103458310	Galectin. (351 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	lgmn	Legumain. (437 aa)
	LOC103457606	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (994 aa)
	il34	Interleukin 34. (223 aa)
	GREM1	Gremlin. (182 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	LOC103456562	Oxidative stress responsive kinase 1b. (543 aa)
	gas6	Uncharacterized protein. (650 aa)
	LOC103479184	Protein kinase domain-containing protein. (292 aa)
	ripor3	RIPOR family member 3. (1001 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	adam10	Uncharacterized protein. (645 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
ENSPREP00000002275	LOC103466013	ENSPREP00000002275	ENSPREP00000021307	DED domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.991
ENSPREP00000021987	Adam17	ENSPREP00000021987	ENSPREP00000021960	ADAM metallopeptidase domain 17b.	Pep_M12B_propep domain-containing protein.	0.932
ENSPREP00000022497	LOC103479265	ENSPREP00000022497	ENSPREP00000019003	G_PROTEIN_RECEP_F1_2 domain-containing protein.	SCY domain-containing protein.	0.912
ENSPREP00000022535	LOC103479265	ENSPREP00000022535	ENSPREP00000019003	G_PROTEIN_RECEP_F1_2 domain-containing protein.	SCY domain-containing protein.	0.912
ENSPREP00000023825	LOC103457606	ENSPREP00000023825	ENSPREP00000028576	SH2 domain-containing protein.	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.494
ENSPREP00000023825	LOC103472469	ENSPREP00000023825	ENSPREP00000017329	SH2 domain-containing protein.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.494
ENSPREP00000023825	LOC103475221	ENSPREP00000023825	ENSPREP00000017059	SH2 domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.494
ENSPREP00000023825	abl1	ENSPREP00000023825	ENSPREP00000021197	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.961
ENSPREP00000023825	abl2	ENSPREP00000023825	ENSPREP00000026823	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.961
ENSPREP00000023825	crk	ENSPREP00000023825	ENSPREP00000013741	SH2 domain-containing protein.	CRK proto-oncogene, adaptor protein.	0.901
ENSPREP00000023825	crkl	ENSPREP00000023825	ENSPREP00000009681	SH2 domain-containing protein.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.909
ENSPREP00000023825	ptk2	ENSPREP00000023825	ENSPREP00000014357	SH2 domain-containing protein.	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.494
ENSPREP00000030326	LOC103461485	ENSPREP00000030326	ENSPREP00000010220	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.902
ENSPREP00000030326	LOC103462560	ENSPREP00000030326	ENSPREP00000000427	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.991
LOC103457606	ENSPREP00000023825	ENSPREP00000028576	ENSPREP00000023825	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	SH2 domain-containing protein.	0.494
LOC103457606	crk	ENSPREP00000028576	ENSPREP00000013741	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	CRK proto-oncogene, adaptor protein.	0.494
LOC103457606	crkl	ENSPREP00000028576	ENSPREP00000009681	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.494
LOC103458658	LOC103479265	ENSPREP00000005256	ENSPREP00000019003	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.912