(29 nodes) Stem cell proliferation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nf1	Neurofibromin 1b. (2742 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	ETV6	ETS variant 6. (472 aa)
	mecom	MDS1 and EVI1 complex locus. (1254 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (831 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	cdkn2c	ANK_REP_REGION domain-containing protein. (167 aa)
	ENSPREP00000027668	Centrosomal protein 120. (452 aa)
	Cep120	DUF3668 domain-containing protein. (223 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	LOC103464190	ANK_REP_REGION domain-containing protein. (161 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (639 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	ENSPREP00000011770	RING-type domain-containing protein. (786 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	znrf3	Zinc and ring finger 3. (891 aa)
	bysl	Bystin-like. (442 aa)
	ENSPREP00000007854	Uncharacterized protein. (143 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ism1	Isthmin 1. (505 aa)
	lig4	DNA ligase. (908 aa)
	kdf1	Keratinocyte differentiation factor 1a. (362 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	LOC103480536	Methyltransferase like 3; Belongs to the MT-A70-like family. (287 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	arih2	RBR-type E3 ubiquitin transferase. (500 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cep120	ENSPREP00000027668	ENSPREP00000027686	ENSPREP00000027668	DUF3668 domain-containing protein.	Centrosomal protein 120.	0.926
ENSPREP00000007854	LOC103480536	ENSPREP00000007854	ENSPREP00000015801	Uncharacterized protein.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.899
ENSPREP00000011770	znrf3	ENSPREP00000011770	ENSPREP00000006299	RING-type domain-containing protein.	Zinc and ring finger 3.	0.732
ENSPREP00000027668	Cep120	ENSPREP00000027668	ENSPREP00000027686	Centrosomal protein 120.	DUF3668 domain-containing protein.	0.926
LOC103475119	fgf2	ENSPREP00000027136	ENSPREP00000009634	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.556
LOC103480536	ENSPREP00000007854	ENSPREP00000015801	ENSPREP00000007854	Methyltransferase like 3; Belongs to the MT-A70-like family.	Uncharacterized protein.	0.899
LOC103480536	ythdf2	ENSPREP00000015801	ENSPREP00000028675	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.506
brca2	ercc2	ENSPREP00000018297	ENSPREP00000028527	BRCA2 DNA repair associated.	Excision repair cross-complementation group 2.	0.644
brca2	lig4	ENSPREP00000018297	ENSPREP00000010705	BRCA2 DNA repair associated.	DNA ligase.	0.616
brca2	nf1	ENSPREP00000018297	ENSPREP00000021407	BRCA2 DNA repair associated.	Neurofibromin 1b.	0.557
brca2	xrcc5	ENSPREP00000018297	ENSPREP00000014485	BRCA2 DNA repair associated.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.549
ercc2	brca2	ENSPREP00000028527	ENSPREP00000018297	Excision repair cross-complementation group 2.	BRCA2 DNA repair associated.	0.644
ercc2	lig4	ENSPREP00000028527	ENSPREP00000010705	Excision repair cross-complementation group 2.	DNA ligase.	0.619
ercc2	xrcc5	ENSPREP00000028527	ENSPREP00000014485	Excision repair cross-complementation group 2.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.552
fgf2	LOC103475119	ENSPREP00000009634	ENSPREP00000027136	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.556
lig4	brca2	ENSPREP00000010705	ENSPREP00000018297	DNA ligase.	BRCA2 DNA repair associated.	0.616
lig4	ercc2	ENSPREP00000010705	ENSPREP00000028527	DNA ligase.	Excision repair cross-complementation group 2.	0.619
lig4	xrcc5	ENSPREP00000010705	ENSPREP00000014485	DNA ligase.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.986
nf1	brca2	ENSPREP00000021407	ENSPREP00000018297	Neurofibromin 1b.	BRCA2 DNA repair associated.	0.557
xrcc5	brca2	ENSPREP00000014485	ENSPREP00000018297	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	BRCA2 DNA repair associated.	0.549