STRINGSTRING
vegfc vegfc LOC103462291 LOC103462291 LOC103472230 LOC103472230 ENSPREP00000004603 ENSPREP00000004603 sox17 sox17 hmga2 hmga2 kdm1a kdm1a LOC103477773 LOC103477773 LOC103477771 LOC103477771 LOC103477270 LOC103477270 ENSPREP00000011628 ENSPREP00000011628 LOC103477355 LOC103477355 kdf1 kdf1 LOC103473053 LOC103473053 nf2 nf2 pdcd2 pdcd2 tgfbr2 tgfbr2 ptprc ptprc ENSPREP00000018426 ENSPREP00000018426 nf1 nf1 ENSPREP00000022877 ENSPREP00000022877 LOC103461155 LOC103461155 fermt1 fermt1 LOC103479463 LOC103479463 TGFBR2 TGFBR2 LOC103475119 LOC103475119 cdkn2c cdkn2c dgcr8 dgcr8 LOC103464190 LOC103464190 LOC103467917 LOC103467917 atxn1l atxn1l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
LOC103462291Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
LOC103472230Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (894 aa)
ENSPREP00000004603Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
sox17SRY-box transcription factor 17. (399 aa)
hmga2Uncharacterized protein. (115 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
LOC103477773Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
LOC103477771Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
LOC103477270Uncharacterized protein. (689 aa)
ENSPREP00000011628Uncharacterized protein. (564 aa)
LOC103477355Protein kinase domain-containing protein. (582 aa)
kdf1Keratinocyte differentiation factor 1a. (362 aa)
LOC103473053Uncharacterized protein; Belongs to the argonaute family. (695 aa)
nf2Neurofibromin 2b (merlin). (615 aa)
pdcd2Programmed cell death 2. (361 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1230 aa)
ENSPREP00000018426Uncharacterized protein. (108 aa)
nf1Neurofibromin 1b. (2742 aa)
ENSPREP00000022877Uncharacterized protein. (62 aa)
LOC103461155Neurofibromin 2a (merlin). (394 aa)
fermt1Fermitin family member 1. (666 aa)
LOC103479463Sirtuin 6. (339 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
LOC103475119Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
cdkn2cANK_REP_REGION domain-containing protein. (167 aa)
dgcr8DGCR8 microprocessor complex subunit. (787 aa)
LOC103464190ANK_REP_REGION domain-containing protein. (161 aa)
LOC103467917Uncharacterized protein. (577 aa)
atxn1lAtaxin 1-like. (827 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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