(26 nodes) Intrinsic apoptotic signaling pathway by p53 class mediator network (Poecilia reticulata)

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Predicted Interactions

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Your Input:
	JMY	Junction mediating and regulatory protein, p53 cofactor. (876 aa)
	ENSPREP00000024365	LITAF domain-containing protein. (239 aa)
	chek2	Checkpoint kinase 2. (510 aa)
	RPS19	Ribosomal protein S19. (146 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (496 aa)
	LOC103468700	LITAF domain-containing protein. (199 aa)
	cdip1	Cell death-inducing p53 target 1. (223 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOC103477840	Ribosomal protein S19. (161 aa)
	ENSPREP00000006149	Zinc finger protein 385B. (434 aa)
	bag6	BCL2 associated athanogene 6. (1194 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (574 aa)
	sirt1	Sirtuin 1. (677 aa)
	casp6	Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (312 aa)
	e2f1	E2F transcription factor 1. (477 aa)
	atad5	ATPase family AAA domain containing 5a. (1822 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	snw1	SNW domain containing 1. (536 aa)
	JMY-2	Junction mediating and regulatory protein, p53 cofactor. (901 aa)
	phlda3	Pleckstrin homology-like domain, family A, member 3. (134 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (670 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JMY	LOC103468460	ENSPREP00000004293	ENSPREP00000026558	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 b.	0.714
JMY	LOC103482005	ENSPREP00000004293	ENSPREP00000030842	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 a.	0.714
JMY-2	LOC103468460	ENSPREP00000028307	ENSPREP00000026558	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 b.	0.714
JMY-2	LOC103482005	ENSPREP00000028307	ENSPREP00000030842	Junction mediating and regulatory protein, p53 cofactor.	E1A binding protein p300 a.	0.714
LOC103468460	JMY	ENSPREP00000026558	ENSPREP00000004293	E1A binding protein p300 b.	Junction mediating and regulatory protein, p53 cofactor.	0.714
LOC103468460	JMY-2	ENSPREP00000026558	ENSPREP00000028307	E1A binding protein p300 b.	Junction mediating and regulatory protein, p53 cofactor.	0.714
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	e2f1	ENSPREP00000026558	ENSPREP00000001819	E1A binding protein p300 b.	E2F transcription factor 1.	0.627
LOC103468460	sirt1	ENSPREP00000026558	ENSPREP00000003960	E1A binding protein p300 b.	Sirtuin 1.	0.587
LOC103468460	snw1	ENSPREP00000026558	ENSPREP00000027074	E1A binding protein p300 b.	SNW domain containing 1.	0.675
LOC103468460	tp63	ENSPREP00000026558	ENSPREP00000024651	E1A binding protein p300 b.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.547
LOC103468460	tp73	ENSPREP00000026558	ENSPREP00000033945	E1A binding protein p300 b.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.547
LOC103477840	RPS19	ENSPREP00000006975	ENSPREP00000018994	Ribosomal protein S19.	Ribosomal protein S19.	0.901
LOC103482005	JMY	ENSPREP00000030842	ENSPREP00000004293	E1A binding protein p300 a.	Junction mediating and regulatory protein, p53 cofactor.	0.714
LOC103482005	JMY-2	ENSPREP00000030842	ENSPREP00000028307	E1A binding protein p300 a.	Junction mediating and regulatory protein, p53 cofactor.	0.714
LOC103482005	LOC103468460	ENSPREP00000030842	ENSPREP00000026558	E1A binding protein p300 a.	E1A binding protein p300 b.	0.902
LOC103482005	e2f1	ENSPREP00000030842	ENSPREP00000001819	E1A binding protein p300 a.	E2F transcription factor 1.	0.627
LOC103482005	sirt1	ENSPREP00000030842	ENSPREP00000003960	E1A binding protein p300 a.	Sirtuin 1.	0.587
LOC103482005	snw1	ENSPREP00000030842	ENSPREP00000027074	E1A binding protein p300 a.	SNW domain containing 1.	0.675
LOC103482005	tp63	ENSPREP00000030842	ENSPREP00000024651	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.547