(70 nodes) Regulation of peptide transport network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (821 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
	slc8b1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (522 aa)
	LOC103466244	Synaptotagmin IXb. (529 aa)
	ENSPREP00000002127	RabBD domain-containing protein. (192 aa)
	LOC103464592	Ubiquinol-cytochrome c reductase complex assembly factor 2. (130 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (336 aa)
	hadh	Hydroxyacyl-CoA dehydrogenase. (318 aa)
	aimp1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1a. (317 aa)
	ENSPREP00000005271	Uncharacterized protein. (210 aa)
	klf7	Kruppel-like factor 7b. (306 aa)
	SLC35F5	Solute carrier family 35 member F5. (549 aa)
	LOC103477767	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	ENSPREP00000010056	G_PROTEIN_RECEP_F1_2 domain-containing protein. (300 aa)
	ENSPREP00000010067	Si:ch211-231m23.4. (304 aa)
	LOC103463687	Midnolin. (540 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (418 aa)
	fgb	Fibrinogen beta chain. (492 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	ENSPREP00000013396	Si:dkey-211g8.6. (312 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC103480397	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1. (553 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (123 aa)
	CCN3	Cellular communication network factor 3. (349 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	LOC103466506	Synaptotagmin VIIa. (606 aa)
	mcu	Mitochondrial calcium uniporter. (376 aa)
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	LOC103470686	Interleukin-1. (247 aa)
	ENSPREP00000019657	Uncharacterized protein. (253 aa)
	LOC103462870	Synaptotagmin IXa. (559 aa)
	LOC103474249	Grancalcin. (230 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	LOC103479803	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC103479798	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (760 aa)
	LOC103479813	Si:ch211-106h4.9. (986 aa)
	ENSPREP00000021170	Uncharacterized protein. (167 aa)
	LOC103480960	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1b. (337 aa)
	LOC103462425	Synaptotagmin VIIb. (468 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (550 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (269 aa)
	stxbp4	Syntaxin binding protein 4. (705 aa)
	capn10	Calpain 10; Belongs to the peptidase C2 family. (670 aa)
	pask	PAS domain containing serine/threonine kinase. (1211 aa)
	LOC103473404	Kruppel like factor 7. (293 aa)
	hmgn3	High mobility group nucleosomal binding domain 3. (110 aa)
	pick1	Protein interacting with prkca 1. (409 aa)
	LOC103465401	GLUCAGON domain-containing protein. (195 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (162 aa)
	rfx6	Regulatory factor X, 6. (831 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ucn	Urotensin 1. (147 aa)
	sri	Uncharacterized protein. (187 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	crh	Corticotropin releasing hormone b. (176 aa)
	LOC103481969	Baculoviral IAP repeat containing 5a. (157 aa)
	kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (372 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	c2cd2l	C2cd2 like. (705 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000021170	LOC103465401	ENSPREP00000021170	ENSPREP00000025838	Uncharacterized protein.	GLUCAGON domain-containing protein.	0.538
ENSPREP00000021170	LOC103470686	ENSPREP00000021170	ENSPREP00000019387	Uncharacterized protein.	Interleukin-1.	0.525
ENSPREP00000021170	LOC103477767	ENSPREP00000021170	ENSPREP00000009818	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.499
ENSPREP00000021170	crh	ENSPREP00000021170	ENSPREP00000029457	Uncharacterized protein.	Corticotropin releasing hormone b.	0.537
ENSPREP00000021170	pdx1	ENSPREP00000021170	ENSPREP00000028858	Uncharacterized protein.	Pancreatic and duodenal homeobox 1.	0.539
ENSPREP00000021170	trh	ENSPREP00000021170	ENSPREP00000023182	Uncharacterized protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.549
LOC103464592	ndufaf2	ENSPREP00000003057	ENSPREP00000026038	Ubiquinol-cytochrome c reductase complex assembly factor 2.	NADH:ubiquinone oxidoreductase complex assembly factor 2.	0.471
LOC103465401	ENSPREP00000021170	ENSPREP00000025838	ENSPREP00000021170	GLUCAGON domain-containing protein.	Uncharacterized protein.	0.538
LOC103465401	crh	ENSPREP00000025838	ENSPREP00000029457	GLUCAGON domain-containing protein.	Corticotropin releasing hormone b.	0.586
LOC103465401	trh	ENSPREP00000025838	ENSPREP00000023182	GLUCAGON domain-containing protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.538
LOC103467002	nr0b2	ENSPREP00000014015	ENSPREP00000013093	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor subfamily 0, group B, member 2a.	0.642
LOC103470076	crh	ENSPREP00000018881	ENSPREP00000029457	Uncharacterized protein.	Corticotropin releasing hormone b.	0.835
LOC103470076	ucn	ENSPREP00000018881	ENSPREP00000027175	Uncharacterized protein.	Urotensin 1.	0.790
LOC103470686	ENSPREP00000021170	ENSPREP00000019387	ENSPREP00000021170	Interleukin-1.	Uncharacterized protein.	0.525
LOC103470686	tnfsf11	ENSPREP00000019387	ENSPREP00000030013	Interleukin-1.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.530
LOC103474249	capn10	ENSPREP00000020247	ENSPREP00000023794	Grancalcin.	Calpain 10; Belongs to the peptidase C2 family.	0.420
LOC103477767	ENSPREP00000021170	ENSPREP00000009818	ENSPREP00000021170	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.499
LOC103479463	sirt4	ENSPREP00000026036	ENSPREP00000003147	Sirtuin 6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.703
aacs	hadh	ENSPREP00000012586	ENSPREP00000003565	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase.	0.960
capn10	LOC103474249	ENSPREP00000023794	ENSPREP00000020247	Calpain 10; Belongs to the peptidase C2 family.	Grancalcin.	0.420