(101 nodes) Negative regulation of canonical Wnt signaling pathway network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSPREP00000017663	TLE_N domain-containing protein. (118 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103456513	Uncharacterized protein. (883 aa)
	tmem131l	Transmembrane 131 like. (1503 aa)
	notum	Uncharacterized protein. (419 aa)
	LOC103464810	Notum pectinacetylesterase 2. (498 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2253 aa)
	lats2	Large tumor suppressor kinase 2. (1157 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	ankrd6	Ankyrin repeat domain 6. (768 aa)
	scyl2	SCY1 like pseudokinase 2. (914 aa)
	LOC103466252	Dickkopf WNT signaling pathway inhibitor 3b. (257 aa)
	LOC103475866	Transmembrane protein 88 a. (189 aa)
	LOC103471319	Bicaudal C homolog 2. (916 aa)
	LOC103468852	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	AXIN2	Axin 2. (834 aa)
	tnn	Tenascin N. (845 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	Cav1	Uncharacterized protein. (84 aa)
	csnk1a1	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa)
	dact1	Uncharacterized protein. (849 aa)
	dact3	Uncharacterized protein. (654 aa)
	kremen1	Kringle containing transmembrane protein 1. (481 aa)
	znrf3	Zinc and ring finger 3. (891 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	frmd8	FERM domain containing 8. (402 aa)
	ENSPREP00000008739	NEDD4 binding protein 3. (472 aa)
	LOC103469222	Axin 2 (conductin, axil). (837 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (924 aa)
	nkd1	NKD inhibitor of WNT signaling pathway 1. (477 aa)
	LOC103472964	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (449 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (773 aa)
	tmem64	Transmembrane protein 64. (351 aa)
	ddit3	DNA-damage-inducible transcript 3. (309 aa)
	axin1	Axin 1. (850 aa)
	LOC103480354	Vang-like protein. (525 aa)
	tmem170b	Transmembrane protein 170B. (153 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	LOC103478434	Trophoblast glycoprotein-like. (363 aa)
	lmbr1	Limb development membrane protein 1; Belongs to the LIMR family. (486 aa)
	LOC103463417	Cylindromatosis (turban tumor syndrome), like. (616 aa)
	LOC103469968	Uncharacterized protein. (771 aa)
	LOC103480376	Uncharacterized protein. (861 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC103475592	LRRCT domain-containing protein. (354 aa)
	LOC103465844	Sizzled. (338 aa)
	nphp4	Uncharacterized protein. (1207 aa)
	ENSPREP00000015938	Nephronophthisis 4. (230 aa)
	bicc1	BicC family RNA binding protein 1a. (913 aa)
	LOC103466531	Uncharacterized protein. (754 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (696 aa)
	ubac2	UBA domain containing 2. (353 aa)
	LOC103463552	TLE family member 2, transcriptional corepressor a. (776 aa)
	ENSPREP00000017609	TLE family member 2, transcriptional corepressor b. (353 aa)
	ENSPREP00000017639	TLE_N domain-containing protein. (123 aa)
	tle5	TLE family member 5, transcriptional modulator. (199 aa)
	LOC103463292	Usher syndrome 1C binding protein 1. (792 aa)
	LOC103478337	R-spondin 3. (325 aa)
	shisa3	Shisa family member 3. (278 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (438 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	tmem88	Uncharacterized protein. (228 aa)
	LOC103480964	Dickkopf_N domain-containing protein. (205 aa)
	sfrp1	Secreted frizzled-related protein 1a. (305 aa)
	LOC103471999	Trophoblast glycoprotein a. (367 aa)
	LOC103461138	TLE family member 5, transcriptional modulator. (203 aa)
	tpbg	Trophoblast glycoprotein b. (359 aa)
	LOC103470121	Leucine zipper, putative tumor suppressor family member 3b. (1097 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	lats1	Large tumor suppressor kinase 1. (1028 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	pfdn5	Prefoldin 5. (155 aa)
	amer2	APC membrane recruitment protein 2. (695 aa)
	Cby1	Chibby homolog 1 (Drosophila). (189 aa)
	apc	APC regulator of WNT signaling pathway. (2002 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	sox13	SRY-box transcription factor 13. (632 aa)
	LOC103476867	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (703 aa)
	TLE4	Uncharacterized protein. (783 aa)
	LOC103467455	Uncharacterized protein. (275 aa)
	sfrp5	Secreted frizzled-related protein 5. (323 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	GREM1	Gremlin. (182 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	igfbp6	Insulin-like growth factor binding protein 6b. (210 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	zc3h12b	APC membrane recruitment protein 1. (986 aa)
	sostdc1	Sclerostin domain containing 1a. (219 aa)
	lmbr1l	Limb development membrane protein 1-like; Belongs to the LIMR family. (492 aa)
	frzb	Frizzled related protein. (331 aa)
	nkd2	NKD inhibitor of WNT signaling pathway 2a. (375 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2620 aa)
	ENSPREP00000032877	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (330 aa)
	LOC103465561	Cylindromatosis (turban tumor syndrome), b. (715 aa)
	LOC103462479	Dickkopf WNT signaling pathway inhibitor 3a. (275 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	LOC103470891	ENSPREP00000003236	ENSPREP00000030084	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.483
AXIN2	LOC103470892	ENSPREP00000003236	ENSPREP00000030097	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.483
AXIN2	LOC103472964	ENSPREP00000003236	ENSPREP00000010416	Axin 2.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.794
AXIN2	apc	ENSPREP00000003236	ENSPREP00000025269	Axin 2.	APC regulator of WNT signaling pathway.	0.809
AXIN2	apc2	ENSPREP00000003236	ENSPREP00000001048	Axin 2.	APC regulator of WNT signaling pathway 2.	0.809
AXIN2	csnk1a1	ENSPREP00000003236	ENSPREP00000003942	Axin 2.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.841
AXIN2	gsk3a	ENSPREP00000003236	ENSPREP00000020500	Axin 2.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.794
AXIN2	gsk3b	ENSPREP00000003236	ENSPREP00000001029	Axin 2.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.827
AXIN2	stk11	ENSPREP00000003236	ENSPREP00000026606	Axin 2.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.432
AXIN2	zc3h12b	ENSPREP00000003236	ENSPREP00000030695	Axin 2.	APC membrane recruitment protein 1.	0.761
Cav1	LOC103477848	ENSPREP00000003891	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.418
ENSPREP00000015938	lats1	ENSPREP00000015938	ENSPREP00000023690	Nephronophthisis 4.	Large tumor suppressor kinase 1.	0.660
ENSPREP00000015938	lats2	ENSPREP00000015938	ENSPREP00000001157	Nephronophthisis 4.	Large tumor suppressor kinase 2.	0.660
ENSPREP00000015938	nphp4	ENSPREP00000015938	ENSPREP00000015922	Nephronophthisis 4.	Uncharacterized protein.	0.899
ENSPREP00000017609	LOC103461138	ENSPREP00000017609	ENSPREP00000022405	TLE family member 2, transcriptional corepressor b.	TLE family member 5, transcriptional modulator.	0.900
ENSPREP00000017609	tle5	ENSPREP00000017609	ENSPREP00000017706	TLE family member 2, transcriptional corepressor b.	TLE family member 5, transcriptional modulator.	0.898
ENSPREP00000020277	LOC103472964	ENSPREP00000020277	ENSPREP00000010416	RBR-type E3 ubiquitin transferase.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.434
ENSPREP00000020277	gsk3a	ENSPREP00000020277	ENSPREP00000020500	RBR-type E3 ubiquitin transferase.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.434
ENSPREP00000020277	gsk3b	ENSPREP00000020277	ENSPREP00000001029	RBR-type E3 ubiquitin transferase.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.434
ENSPREP00000030224	LOC103462479	ENSPREP00000030224	ENSPREP00000034164	PID domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 3a.	0.428